The invention belongs to the technical field of fuel cells, and relates to a manufacturing method of a Fe-Ni-Cr alloy fuel cell bi-polar plate. The method comprises the following steps of: mixing materials, wherein the materials comprise Fe with the content of x (atomic percentage), Ni with the content of y (atomic percentage) and Cr with the content of z (atomic percentage), x is equal to 37-39 percent, y is equal to 32-34 percent, z is equal to 28-30 percent, and the sum of x, y and z is 100 percent; smelting FexNiyCrz alloy by utilizing vacuum induction; molding and machining a metal plate; carrying out surface chemical treatment; placing the metal plate with a flow field in an HF water solution with the volume concentration of 45-50 percent under 20-30 DEG C and soaking for 7-9 min, taking out, cleaning and drying. The fuel cell bi-polar plate prepared by the method has the advantages of excellent corrosion resistance and conductivity, simple manufacturing process, low operation temperature, no easy deformation of the plate, suitability for assembly of a fuel cell pile and low cost.