The invention relates to a grinding process of a sealing surface of a ball valve. The grinding process comprises the steps of rough grinding, fine grinding, ultrafine grinding, and grinding and cleaning of a valve seat and a sphere, wherein a diamond paste and an engine oil mixture are adopted in the rough grinding, the particle size phi of the selected diamond paste ranges from 40mu m to 10mu m, so that the scratch removal and sphere rounding can be realized; in fine grinding, a diamond paste, kerosene and a microcrystal graphite mixture are adopted, the particle size phi of the selected diamond paste ranges from 7mu m to 5mu m, so that the primary mirror surface effect can be achieved; in the ultrafine grinding, a diamond paste and a microcrystal graphite and kerosene mixture are adopted, the particle size phi of the selected diamond paste is smaller than 5mu m, the rotating speed of the sphere is controlled to be below 5rpm to achieve the mirror surface effect, and finally the kerosene is coated on the sphere and grinding cleaning are performed to achieve a better mirror surface effect. The sphere ground and the sealing surface of the valve seat can achieve the mirror surface effect, the surface roughness can achieve Ra0.02-0.005, the operation torque is low, the service life is long, the valve seat can be adsorbed on the spherical surface of the sphere, and no leakage exists under the trial pressure of low-pressure nitrogen being 0.6Mpa.