Artificial cowbezoar and chlorpenaleate capsule and preparation method thereof

A technology of Kahuangmin capsules and capsules, which is applied in the new field of medicine, can solve the problems of slow onset of action and poor bioavailability of common dosage forms, and achieve the effects of reasonable formula, significant drug effect and high drug dissolution rate.

Inactive Publication Date: 2015-05-13
SHANGHAI HUAYUAN ANHUI RENJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aminoka Huangmin is often used for patients with symptoms such as nasal congestion, headache, sore throat, and

Method used

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  • Artificial cowbezoar and chlorpenaleate capsule and preparation method thereof
  • Artificial cowbezoar and chlorpenaleate capsule and preparation method thereof
  • Artificial cowbezoar and chlorpenaleate capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of Ankahuangmin capsule capsule, comprising following raw material components (by weight percentage):

[0023]

[0024]

[0025] Wherein the filler is chitosan oligosaccharide, the lubricant is magnesium stearate, and the disintegrant is poloxamer.

[0026] The preparation method steps are:

[0027] (1) Screening of auxiliary materials: Pass acetaminophen, caffeine, chlorpheniramine maleate, artificial bezoar, chitosan oligosaccharide, magnesium stearate, and poloxamer through a 100-mesh sieve for micronization treatment;

[0028] (2) Ingredients: Proportion by weight is paracetamol 74.5%, caffeine 5.5%, chlorpheniramine maleate 0.8%, artificial bezoar 2.6%, chitooligosaccharide 5.6%, magnesium stearate 4.0%, Poloxamer 7.0% for batching;

[0029] (3) Total blending: add acetaminophen, caffeine, chlorpheniramine maleate, artificial bezoar, fillers, lubricants, and disintegrants with water and stir for 4.5 hours to form a paste mixture;

[0030] (4) Spray ...

Embodiment 2

[0033] A kind of Ankahuangmin capsule capsule, comprising following raw material components (by weight percentage):

[0034]

[0035] Wherein the filler is chitosan oligosaccharide, the lubricant is zinc stearate, and the disintegrant is copovidone.

[0036] The preparation method steps are:

[0037] (1) Screening of auxiliary materials: Pass acetaminophen, caffeine, chlorpheniramine maleate, artificial calculus bezoar, oligochitosan, zinc stearate, and copovidone through a 100-mesh sieve for micronization treatment;

[0038] (2) Ingredients: 74.7% by weight of paracetamol, 5.8% of caffeine, 0.9% of chlorpheniramine maleate, 2.5% of artificial bezoar, 5.4% of chitosan oligosaccharide, 4.0% of zinc stearate, Copovidone 6.7% is used for batching;

[0039] (3) Total blending: add acetaminophen, caffeine, chlorpheniramine maleate, artificial bezoar, oligochitosan, zinc stearate, and copovidone with water and stir for 5 hours to form a paste mixture;

[0040] (4) Spray granul...

Embodiment 3

[0043] A kind of Ankahuangmin capsule capsule, comprising following raw material components (by weight percentage):

[0044]

[0045] Wherein the filler is seaweed polysaccharide, the lubricant is silicon dioxide, and the disintegrant is sodium carboxymethyl starch.

[0046] The preparation method steps are:

[0047] (1) Screening of auxiliary materials: Pass acetaminophen, caffeine, chlorpheniramine maleate, artificial bezoar, seaweed polysaccharide, silicon dioxide, and sodium carboxymethyl starch through a 100-mesh sieve for micronization treatment;

[0048] (2) Ingredients: 74.9% by weight of paracetamol, 5.7% of caffeine, 0.8% of chlorpheniramine maleate, 2.7% of artificial bezoar, 5.9% of seaweed polysaccharide, 3.4% of silicon dioxide, carboxymethyl Sodium starch starch 6.6% for batching;

[0049] (3) Total mixing: add acetaminophen, caffeine, chlorpheniramine maleate, artificial bezoar, seaweed polysaccharide, silicon dioxide, sodium carboxymethyl starch and stir ...

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PUM

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Abstract

The invention relates to an artificial cowbezoar and chlorpenaleate capsule and a preparation method thereof. The artificial cowbezoar and chlorpenaleate capsule is prepared from the following raw materials in percentage by weight: 68-75 percent of paracetamol, 4-6 percent of caffeine, 0.5-1.0 percent of chlorpheniramine maleate, 2-3 percent of artificial calculus bovis, 4-6 percent of a filler, 2-4 percent of a lubricant and 5-7 percent of a disintegrant. The artificial cowbezoar and chlorpenaleate capsule is reasonable in formula, high in drug dissolution, simple in preparation method without pollution, remarkable in efficacy and easy in popularization.

Description

technical field [0001] The invention belongs to the field of new medicine technology, and specifically relates to an Ankahuangmin capsule and a preparation method thereof. Background technique [0002] Viral cold is a common disease of people, including common cold, influenza and viral pharyngitis, etc. It is mainly transmitted through the nasal cavity through air or hand contact. Influenza is an acute respiratory infectious disease caused by influenza virus. Virus exists in the patient's respiratory tract and is transmitted through droplets when the patient coughs or sneezes. The common cold is caused by rhinoviruses, coronaviruses, and parainfluenza viruses. The common cold is much less contagious than influenza, and often occurs individually. When the body's resistance is weakened, it is easy to get sick. The common cold all can fall ill all the year round, and especially season alternation, climate change can cause the incidence of a cold to rise. [0003] Ankahuangmin...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/48A61P11/00A61P11/04A61P29/00A61K31/167A61K31/522A61K31/4402
Inventor 刘俊华钱令齐鸿达
Owner SHANGHAI HUAYUAN ANHUI RENJI PHARMA
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