Extraction technology of artemisinin

Abstract

The invention relates to an extraction technology of artemisinin, and belongs to the technical field of natural plant extraction. The extraction technology comprises the following steps: (1) drying raw materials: putting the raw materials in a drying facility to dry the raw materials; (2) primary preparation of artemisinin: putting the dried raw materials in an extraction tank, adding petroleum ether into the extraction tank, heating, carrying out reflux extraction, discharging the liquid extract from the extraction tank after the reflux extraction, allowing the liquid extract to stand still for a while, collecting the supernate, making the supernate go through a silica gel column, then washing the silica gel column by petroleum ether, collecting the fractions containing artemisinin, transferring the fractions to a condensing tank, condensing the fractions, transferring the condensed liquid to a crystallization tank when the liquid in the condensing tank start to crystallize, carrying out crystallization in the crystallization tank, filtering to obtain the crystals, and drying the crystals so as to obtain crude artemisinin; (3) artemisinin refinement: placing the crude artemisinin in an alcohol-precipitation tank, dissolving the crude artemisinin by ethanol with a concentration of 85-95%, wherein the volume of the ethanol is 60 to 70 times of that of the crude artemisinin, allowing the solution to stand still for a while, collecting the supernate, subjecting the supernate to fine filtration, transferring the filtrate to a condensing tank, condensing the filtrate, allowing the condensed filtrate to stand still so as to carry out crystallization, filtering to obtain the crystals, and finally drying the crystals in vacuum so as to obtain refined artemisinin.

Description

technical field [0001] The invention relates to the technical field of natural element extraction, in particular to an artemisinin extraction process. Background technique [0002] Artemisin (artemisin) is an artemisinin drug extracted from the medicinal plant Artemisia annua L., which is a sesquiterpene lactone compound containing a peroxide group. It is the only internationally recognized herbal medicine in my country. The Chinese herbal medicine extract developed by western medicine is an anti-malarial raw material drug that the World Health Organization (WHO) clearly stipulates to replace quinine. my country's artemisinin production and sales account for more than 90% of the global production and sales, and China's extraction technology also represents the world's level. [0003] At present, the technology of extracting artemisinin from Artemisia annua in China is mainly the traditional organic solvent extraction and separation method, that is, using organic solvents suc...

AI Technical Summary

Problems solved by technology

After entering the 1990s, supercritical carbon dioxide extraction technology began to be used to extract medicinal active ingredients from medicinal plants. It is reported that my country has also studied the supercritical fluid extraction of artemisinin, but in the end, this method has a large investment in equipment and production. The shortcomings of low capacity, high operating costs, and lack of market competitiveness have not yet carried out large-scale industrial production at home and abroad.