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Human body biological dressing for covering burn wound surfaces and applications of dressing

A biological dressing, human body technology, applied in the fields of medical science, bandages, absorbent pads, etc., can solve the problems of easy ingrowth of granulation tissue on the wound surface, affecting primary healing, and large amount of water evaporation on the wound surface, so as to prevent wound surface infection and protein loss. , Conducive to the growth of epithelial cells and improve the quality of wound healing

Active Publication Date: 2015-06-03
BEIJING JAYYALIFE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Traditional dressings such as gauze and cotton pads have the following disadvantages: ① cannot keep the wound moist and delay wound healing; ② dressing fibers are easy to fall off, causing foreign body reactions and affecting healing; ③ wound granulation tissue is easy to grow into the mesh of the dressing, and the Can cause pain; ④ When the dressing is soaked, pathogens can easily pass through; ⑤ When changing the dressing, it is easy to damage the new tissue; ⑥ The workload of changing the dressing is heavy
Foam-type synthetic dressings such as Allevyn, Ixralo and other products have large pores, and the wound granulation tissue is easy to grow in, making it difficult to remove the membrane and cause re-trauma, and it is easy to be contaminated by bacteria, and it is easy to leave debris on the wound
Spray-type synthetic dressings such as Hydron, Aeroplast and other products have the following disadvantages: poor adhesion and tensile strength; poor moisture retention, large wound water evaporation; water solubility of the spray film can make it softened by wound exudate and keep for a short time ; No infection control effect, used to contaminate the wound surface prone to submembranous infection
However, the existing allogeneic skin has clinical problems such as high storage conditions, antigenicity, space occupation, and susceptibility to infection by pathogenic microorganisms.
Especially due to the obvious immune rejection caused by its antigenicity, it usually dissolves and falls off in about 2-3 weeks, and the wound surface is exposed, which affects the primary healing

Method used

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  • Human body biological dressing for covering burn wound surfaces and applications of dressing
  • Human body biological dressing for covering burn wound surfaces and applications of dressing
  • Human body biological dressing for covering burn wound surfaces and applications of dressing

Examples

Experimental program
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preparation example Construction

[0141] 4. Preparation of Bio-Human Biological Dressing Extraction

[0142] Cut the human biological dressing into pieces in an ultra-clean bench, put it in a blender, add sterilized Ph7.0 phosphate buffer, and stir it into a homogenate. The homogenate was placed in an electric thermostat incubator at 37°C overnight, centrifuged at 12,000 rpm for 10 min, and the supernatant was filtered and sterilized through a 0.22 μm sterile filter. Store in a refrigerator at 4°C. Human biological dressing extracts were prepared 1 day before use.

[0143] 5. Experimental grouping and processing

[0144] Experimental rabbits (60) were divided into four groups: high-dose group (implanted human biological dressing group), low-dose group (leach solution group), negative control group, and positive control group (enhanced immunization group). 15 in each group.

[0145] High-dose group (implanted human biological dressing group): rabbits were anesthetized with 5% pentobarbital, and the dosage w...

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Abstract

The invention provides a human body biological dressing for covering burn wound surfaces and applications of the dressing. Antigen removal and immunogenicity reduction treatment is performed on allograft with biological means, biochemical means and the like, dermis and epidermis are kept, and the clinical effect is far better than that of the allograft. A preparation method of the dressing sequentially comprises steps as follows: soaking treatment with a glutaraldehyde solution; segmentation; soaking treatment with purified water; soaking treatment with a polysorbate 80 solution; soaking treatment with purified water; soaking treatment with an amino acid solution; soaking treatment with purified water; soaking treatment with PBS (phosphate buffered saline); repair and trimming; soaking treatment with a sodium chloride solution; packaging and irradiation. The obtained dressing can purify and clean the wound surfaces, promote growth of granulation tissue, cover granulation wound surfaces, chronic ulcers and bedsores, shorten healing time and be applied to the field of rescue of large-area deep burns, coverage of various burn (wound) surfaces, coverage and treatment of excision surfaces, granular skin-grafting wound surfaces, the granulation surfaces, the chronic ulcers and the bedsores and the like.

Description

[0001] This application is a divisional application of a Chinese invention patent application with an application date of March 28, 2013, an application number of 201310103371.8, and an invention title of "A Method for Making a Human Biological Dressing for Covering Burn Wounds". technical field [0002] The invention relates to a burn wound wound covering material and its application, in particular to a human biological dressing for covering the burn wound with antigen-removed allogeneic skin and reduced immunogenicity and its specific application. Background technique [0003] Burns are the most common skin wounds in peacetime and wartime, and all kinds of damage caused by burns are related to the destruction and loss of skin barrier function. Such as: increased metabolism, decreased body temperature, excessive loss of water, a large loss of protein, and disorders of the endocrine and immune systems. Therefore, it is particularly important to cover wounds with dressings as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/44
Inventor 孙继煌王春元石清东吴文华
Owner BEIJING JAYYALIFE BIOTECH CO LTD
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