Preparation method for aromatic and bacteriostatic chitosan-based wound dressing

A wound dressing and chitosan technology, applied in the field of medical materials, can solve the problems of reducing the concentration of essential oils, affecting the efficacy of sterilization, and short duration of antibacterial action, and achieving the effects of optimizing the environment, pleasant mood, and significant antibacterial effect.

Inactive Publication Date: 2015-07-22
济南科乐医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dressing adopts a dissolution-type bactericidal mechanism, and the release of plant essential oil components makes the antibacter

Method used

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  • Preparation method for aromatic and bacteriostatic chitosan-based wound dressing
  • Preparation method for aromatic and bacteriostatic chitosan-based wound dressing
  • Preparation method for aromatic and bacteriostatic chitosan-based wound dressing

Examples

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[0042] Example 1:

[0043] A preparation method of an aromatic antibacterial chitosan-based wound dressing:

[0044] (1) Stir the tea tree essential oil, menthol and mugwort essential oil at a mass ratio of 1:1:1 at 60 rpm at 4°C. Add 8g sodium chloride, 0.2 potassium chloride g / L, 1.44g disodium hydrogen phosphate, 0.24g dipotassium hydrogen phosphate to 800ml water, stir to fully dissolve, adjust the pH value to 6.5 with hydrochloric acid, and add water to 1000ml , Add 60g Tween 80 to obtain a phosphate buffer solution. Add the essential oil mixture to the phosphate buffer solution at a concentration of 1g / 100mL to obtain a natural aromatic bacteriostatic agent;

[0045] (2) Dissolve 100mg of soy lecithin and 25mg of cholesterol in chloroform and pour into a round bottom flask. Rotate and steam at room temperature to form a uniform film on the bottle wall; add 10ml of natural aromatic bacteriostatic agent in an ultrasonic bath at 55℃ Preheat it to 55°C, then add it to a round bo...

Example Embodiment

[0048] Example 2:

[0049] A preparation method of an aromatic antibacterial chitosan-based wound dressing:

[0050] (1) Stir the tea tree essential oil, menthol and mugwort essential oil at a mass ratio of 1:1:1 at 60 rpm at 4°C. Add 8g sodium chloride, 0.2 potassium chloride g / L, 1.44g disodium hydrogen phosphate, 0.24g dipotassium hydrogen phosphate to 800ml water, stir to fully dissolve, adjust the pH value to 6.5 with hydrochloric acid, and add water to 1000ml , Add 60g Tween 80 to obtain a phosphate buffer solution. Add the essential oil mixture to the phosphate buffer solution at a concentration of 0.2g / 100mL to obtain a natural aromatic bacteriostatic agent;

[0051] (2) Dissolve 100mg of soy lecithin and 25mg of cholesterol in chloroform and pour into a round bottom flask. Rotate and steam at room temperature to form a uniform film on the bottle wall; add 10ml of natural aromatic bacteriostatic agent in an ultrasonic bath at 55℃ Preheat it to 55°C, then add it to a round ...

Example Embodiment

[0054] Example 3:

[0055] A preparation method of an aromatic antibacterial chitosan-based wound dressing:

[0056] (1) Stir the tea tree essential oil, menthol and mugwort essential oil at a mass ratio of 1:1:1 at 60 rpm at 4°C. Add 8g sodium chloride, 0.2 potassium chloride g / L, 1.44g disodium hydrogen phosphate, 0.24g dipotassium hydrogen phosphate to 800ml water, stir to fully dissolve, adjust the pH value to 6.5 with hydrochloric acid, and add water to 1000ml , Add 60g Tween 80 to obtain a phosphate buffer solution. Add the essential oil mixture to the phosphate buffer solution at a concentration of 2g / 100mL to obtain a natural aromatic bacteriostatic agent;

[0057] (2) Dissolve 100mg of soy lecithin and 25mg of cholesterol in chloroform and pour into a round bottom flask. Rotate and steam at room temperature to form a uniform film on the bottle wall; add 10ml of natural aromatic bacteriostatic agent in an ultrasonic bath at 55℃ Preheat it to 55°C, then add it to a round bo...

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Abstract

The invention discloses a preparation method for aromatic and bacteriostatic chitosan-based wound dressing. The preparation method comprises the following steps: mixing tea tree essential oil, menthol and folium artemisiae argyi essential oil according to a certain proportion to obtain a natural aromatic bacteriostatic agent; coating lipidosome with the natural aromatic bacteriostatic agent to obtain aromatic and bacteriostatic lipidosome; dispersing the aromatic and bacteriostatic lipidosome into a chitosan-sodium alginate-gelatin solution, and performing freeze drying according to certain process to obtain the aromatic and bacteriostatic chitosan-based wound dressing. The aromatic and bacteriostatic chitosan-based wound dressing is of a porous structure and efficient in bacteria capturing effect, lasting, broad-spectrum, efficient and antibacterial, good in slow release and antibacterial performance, hemostasis, water absorption and gas permeability and good in biocompatibility, has certain mint flavor, and has obvious curative effect in large wounds and burns.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method of an aromatic antibacterial chitosan-based wound dressing. Background technique [0002] Chitosan is a natural macromolecule biological polysaccharide chitin deacetylation product, has excellent solvent resistance and alkali resistance, good biocompatibility and skin affinity, antibacterial, film-forming, breathable, It has good water absorption and moisturizing properties, can stop bleeding, promote wound healing, etc., and can be used as a medical material. However, due to the high brittleness and poor mechanical properties of chitosan, its use alone is limited. At present, there are a large number of literature reports that chitosan and other polymers are blended and modified to prepare dressing films with excellent properties. [0003] Tea tree essential oil is an oily extract obtained from the leaves of Melaleuca alternifolia thr...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61L15/46
Inventor 葛彦汤佳鹏唐虹王芳芳张陈成
Owner 济南科乐医药有限公司
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