Mussel-adhered and cytomembrane antifouling double-bionic multi-armed PEG and preparation method thereof

A kind of polymer and general formula technology, which is applied in paints containing biocide, antifouling/underwater coatings, coatings, etc., and can solve the problem of low coating density

Active Publication Date: 2015-07-29
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main purpose of the present invention is to provide a mussel adhesion and cell membrane anti-fouling double bionic multi-arm PEG that can spontaneously adhere to the surface of various materials. The branched structure of the multi-arm PEG can effectively solve the problem of low coating density ; The catechol group at the end of the PEG part can spontaneously combine with the surface of almost various substrates through hydrophobic interaction, coordination, oxidative polymerization, etc., so that the highly hydrophilic polymer coating is fix

Method used

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  • Mussel-adhered and cytomembrane antifouling double-bionic multi-armed PEG and preparation method thereof
  • Mussel-adhered and cytomembrane antifouling double-bionic multi-armed PEG and preparation method thereof
  • Mussel-adhered and cytomembrane antifouling double-bionic multi-armed PEG and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] The oligomer preparation method containing p-nitrophenoxyformyl active ester group and phosphorylcholine group is as follows: prepare with reference to literature method (K.Ishihara, et al . Polym. J. 1990 , 22 , 355; T. Konno, et al . Biomacromolecules 2004 , 5 , 342.) 2-methacryloyloxyethylphosphorylcholine (MPC) and p-nitrophenoxyformyl (poly)ethylene glycol methacrylate (NPEM). Through the "starvation method" reported in the literature (A.L. Lewis, et al . Biomaterials 2000 , 21 , 1847.) synthesized free radical random copolymer p(MPC-co-NPEM), referred to as PMN. The specific process is as follows: add 15 mL of ethanol and 0.006 g of azobisisoheptanonitrile (ABVN) to a 250 mL three-neck flask, install a condenser tube, heat to 65°C and turn on N 2 Oxygen was removed from the system for 30 min. Weigh 5.113 g MPC, 1.271 g NPEM and 0.058 g initiator azobisisoheptanonitrile (ABVN) into a 500 mL round bottom flask, add 200 mL of dry ethanol and 6 mL of ...

Embodiment 2

[0039] The oligomers containing p-nitrophenoxyformyl active ester groups and sulfobetaine groups were prepared as follows: 2-methacryloyloxyethylsulfobetaine (SBMA) was synthesized by the "starvation method" and p-nitrophenoxyformyl (poly)ethylene glycol methacrylate (NPEM) free radical random copolymer p(SBMA-co-NPEM), referred to as PSN. The specific process is as follows: add 10 mL of ethanol and 0.003 g of azobisisoheptanonitrile (ABVN) to a 250 mL three-necked flask, install a condenser tube, heat to 65°C and turn on N 2 Oxygen was removed from the system for 30 min. Weigh 2.295 g of SBMA, 0.636 g of NPEM and 0.029 g of initiator ABVN into a 500 mL round bottom flask, add 100 mL of dry ethanol and 6 mL of tetrahydrofuran to fully dissolve them and transfer them to a constant pressure dropping funnel. Electromagnetic stirring, N 2 Under protection, the mixed solution of the monomer and the initiator was added dropwise into the three-necked bottle, and after the dropwise...

Embodiment 3

[0041] The preparation method of the grafted phosphorylcholine oligomer at the end of the eight-arm PEG part arm: Weigh 0.500 g PEG-(NH 2 ) 8 Dissolve it in a 50 mL round bottom flask with 40 mL of ethanol / TEA and 3 mL of distilled water mixed solution (pH 6.5-7.0), immerse in an oil bath preheated to 60 °C under magnetic stirring, and use 0.376 g of PMN polymer with After 20 mL of ethanol was dissolved, it was added dropwise to the three-necked flask, and after the addition was completed, the reaction was continued for 22 h. After stopping the reaction, remove the small molecules and ungrafted low molecular weight (M w ~5000 g / mol) polymer PMN, use NaOH aqueous solution with a pH of about 9 as the dialyzed external fluid until the yellow color fades (to hydrolyze the unreacted active ester group), and then transition to distilled water to reach the conductivity of the dialyzed external fluid The conductivity is basically the same as that of distilled water. The eight-armed...

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PUM

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Abstract

The invention discloses a catechol Mytilopsis-adhered and amphion-like extracellular membrane structured double-bionic modified multi-armed PEG as shown in the general structural formula (I) and a preparation method thereof. By a simple direct coating mode such as dispensing, spraying, dip-coating or spin-coating, etc. of the PEG, a multi-armed polyethylene glycol flexible chain and amphion-like extracellular membrane structured double anti-biopollution surface is constructed on the surface of various polydopamine-mediated base materials. Due to a branching structure and multiple modifiable ends of the bionic modified multi-armed PEG, it brings the possibility to prepare a functional polymer with multiple functional groups and regulable proportion. As the polydopamine with ultrastrong adhesion is used as a mediation layer, a compact and stable double anti-biopollution coating can still be formed on the surface of almost any base materials on the condition that content of catechol in the multifunctional multi-armed PEG is limited.

Description

technical field [0001] The invention relates to a preparation method of mussel adhesion and cell membrane antifouling double bionic multi-arm PEG and its application to construct anti-biological pollution coatings on the surface of various substrates, belonging to the surface modification of biomedical polymer materials technology field. Background technique [0002] In recent years, a series of problems such as thrombus, inflammation, and infection caused by biological pollutants such as proteins, cells, and bacteria have severely limited the clinical application of various biological materials. Therefore, it is imperative to effectively solve the problem of biological contamination on the surface of biological materials. important. At present, the commonly used simple and easy anti-biological contamination surface construction is mainly to modify the surface of existing biomedical materials, that is, to coat the surface of the base material with a coating with anti-foulin...

Claims

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Application Information

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IPC IPC(8): C08G81/02C08G65/00C09D187/00C09D5/16
Inventor 党媛权苗宫永宽
Owner NORTHWEST UNIV
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