Material with antibacterial and biocompatible surface and preparing method and application thereof

Abstract

The invention discloses a material with an antibacterial and biocompatible surface and a preparing method and application thereof. The preparing method comprises the steps that amination of the surface of a material is achieved with an amino silane coupling agent, so that a surface-aminated material is obtained; the obtained surface-aminated material is made to react with dialdehyde to achieve formylation of the surface of the material, so that a surface-formylated material is obtained; the obtained surface-formylated material is made to react with citicoline chitosan salt to achieve citicoline chitosan salt immobilization of the surface of the material, and washing is conducted to obtain the material with the antibacterial and biocompatible surface. The adopted citicoline chitosan salt has high cytocompatibility, blood compatibility and broad-spectrum antibacterial property in the physiological environment and is biodegradable; furthermore, the citicoline chitosan salt can be fixed to the surface of the material under a mild condition to generate the material with the antibacterial and biocompatible surface, and the material is suitable for implantable and interventional medical devices.

Description

technical field [0001] The invention belongs to the technical field of material surface modification, and in particular relates to a material with antibacterial properties and biocompatibility on the surface, a preparation method and an application. Background technique [0002] The adhesion of microorganisms such as bacteria on the surface of implanted biomaterials or medical devices and the subsequent formation of biofilms are one of the main reasons for implant infection and medical device failure, which seriously threaten human health and life safety. At present, the application of antimicrobial agent coating (active antibacterial) and the formation of anti-bioadhesive surface (inert antibacterial) are two strategies to solve the complications or failure of implanted devices caused by microbial infection. The representative technology of the former is surface coupling or coating antibacterial materials, such as organic small molecule antibacterial agents and synthetic po...

AI Technical Summary

Problems solved by technology

The representative technology of the former is surface coupling or coating antibacterial materials, such as organic small molecule antibacterial agents and synthetic polymer antibacterial agents containing quaternary ammonium, haloamine, guanidine and quaternary phosphine, chitosan and its derivatives, silver-containing compounds Inorganic antibacterial agents, etc., can effectively kill surrounding bacteria and microorganisms, but on the one hand, the bacteria and microorganisms killed on the surface of implanted materials or devices may still cause immune reactions and inflammation; on the other hand, the content of antibacterial active components continues to decline over time , affect the antibacterial effective period, and may have toxic effects on normal cells

The representative technology of the latter is the introduction of polyethylene glycol or polyzwitterions (such as phosphorylcholine, sulfobetaine, etc.) compounds with anti-protein and bacterial adhesion functions on the surface, which can effectively reduce bacterial adhesion and inhibit biofilm formation. Formation, and has good hemocompatibility and cell compatibility, but there is still the risk of bacterial introduction and implantation failure in clinical use

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