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Preparation method of photoelectrochemical sensor for detecting dexamethasone based on in-situ generation of cadmium sulfide

A dexamethasone and photoelectrochemical technology, which is applied in the field of new functional materials and biosensing detection, can solve the problems of large sample consumption, complicated processing and complicated operation, and achieves low detection limit, high sensitivity detection, and simple operation method. Effect

Active Publication Date: 2016-01-20
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these detection methods have problems such as complicated sample pretreatment, cumbersome operation, large amount of sample required, and long time consumption, which cannot well meet the needs of quantitative analysis to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Preparation of photoelectrochemical sensors

[0044] (1) Preparation of carboxylated carbon nitride nanosheets

[0045]Add 5g of melamine to a ceramic crucible, calcinate at 500°C for 3h in a muffle furnace, cool to room temperature, take 0.5g of carbon nitride and add 50, 2.5mol / L nitric acid aqueous solution, reflux at 120~130°C for 20h, cool to After room temperature, the reflux product was centrifuged and washed with ultrapure water, and dried in vacuum at 30°C for 10 hours;

[0046] (2) Preparation of bismuth sulfide nanorods

[0047] Dissolve 1.0g of bismuth nitrate in 10mL of ethylene glycol, pass nitrogen gas for 15min to obtain solution A, dissolve 0.7g of sodium sulfide in 5mL of ethylene glycol and 10mL of ultrapure water mixture, and stir evenly for 15min to obtain solution B. Solution B was added dropwise to solution A under magnetic stirring to obtain solution C, then 1.0g urea and 5mL ultrapure water were added to mixed solution C and stirre...

Embodiment 2

[0056] Example 2 Preparation of photoelectrochemical sensors

[0057] (1) Preparation of carboxylated carbon nitride nanosheets

[0058] Add 5g of melamine to a ceramic crucible, calcinate at 550°C for 4h in a muffle furnace, cool to room temperature, take 1.0g of carbon nitride and add 50mL, 5mol / L nitric acid aqueous solution to reflux at 125°C for 24h, cool to room temperature, The reflux product was centrifuged and washed with ultrapure water, and dried under vacuum at 35°C for 12 hours;

[0059] (2) Preparation of bismuth sulfide nanorods

[0060] Dissolve 2.0g of bismuth nitrate in 25mL of ethylene glycol, pass nitrogen gas for 15min to obtain solution A, dissolve 1.4g of sodium sulfide in a mixture of 10mL of ethylene glycol and 20mL of ultrapure water, and stir evenly for 15min to obtain solution B. Solution B was added dropwise to solution A under magnetic stirring to obtain solution C, then 2.0g urea and 10mL ultrapure water were added to mixed solution C and sti...

Embodiment 3

[0069] Example 3 Preparation of photoelectrochemical sensors

[0070] (1) Preparation of carboxylated carbon nitride nanosheets

[0071] Add 5g of melamine to a ceramic crucible and calcinate at 600°C for 5h in a ceramic crucible, cool to room temperature, take 2.0g of carbon nitride and add 200mL, 10mol / L nitric acid aqueous solution to reflux at 130°C for 28h, cool to room temperature, and reflux The product was centrifuged and washed with ultrapure water, and dried under vacuum at 40°C for 14 hours;

[0072] (2) Preparation of bismuth sulfide nanorods

[0073] Dissolve 3.0g of bismuth nitrate in 50mL of ethylene glycol, pass nitrogen gas for 15min to obtain solution A, dissolve 2.8g of sodium sulfide in a mixture of 20mL of ethylene glycol and 40mL of ultrapure water, and stir evenly for 15min to obtain solution B. Solution B was added dropwise to solution A under magnetic stirring to obtain solution C, then 3.0g urea and 20mL ultrapure water were added to mixed solutio...

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Abstract

The invention relates to a preparation method of a photoelectrochemical sensor for detecting dexamethasone based on in-situ generation of cadmium sulfide. The method specifically comprises the following steps: as carboxylated carbon nitride and bismuth sulfide are taken as substrate materials, and labeling a dexamethasone antibody by using titanium dioxide subjected to cadmium ion functionalization. Sodium sulfide is directly dropwise added to the electrode surface, a narrow band-gap cadmium sulfide semiconductor nanometer material with the high photoelectric conversion efficiency is generated in situ, and a photocurrent signal is generated under light source irradiation with visible wavelength. A porous titanium dioxide carrier and a cadmium sulfide energy band are well matched, so that the photoelectric conversion efficiency of the cadmium sulfide is improved, the high-sensitivity detection of dexamethasone is realized, and the detection limit is 2pg / mL.

Description

technical field [0001] The invention relates to a preparation method of a photoelectrochemical sensor for detecting dexamethasone based on in-situ generation of cadmium sulfide. Specifically, carboxylated carbon nitride and bismuth sulfide are used as base materials, and titanium dioxide functionalized with cadmium ions is used as an antibody marker to prepare a A photoelectrochemical sensor for detecting dexamethasone belongs to the technical field of new functional materials and biosensing detection. Background technique [0002] At present, the residues of veterinary drugs in livestock and poultry meat are relatively serious. Dexamethasone is a synthetic adrenal cortex hormone drug with anti-inflammatory, anti-allergic and anti-shock effects. However, its residue in animal food will not only cause direct harm to human health, but also cause great harm to the development of animal husbandry and the ecological environment. Long-term consumption of food containing veterina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
Inventor 魏琴王雪萍闫涛李燕马洪敏杜斌
Owner UNIV OF JINAN
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