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Green tea extract nanostructured lipid carrier and preparation method thereof

A technology of nanostructured lipids and green tea extracts, which is applied in the fields of pharmaceutical formulations, cosmetic preparations, and toiletry preparations, etc., and can solve the problems of green tea extract bioavailability, SLN particle size increase, light, heat, etc. that affect the appearance of finished products. Instability and other problems, the preparation method is simple and controllable, the loading capacity is improved, and the effect of anti-aging ability is achieved

Inactive Publication Date: 2016-02-24
苏州纳康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In view of the above advantages of tea polyphenols, it is more and more popular to use green tea extracts directly in cosmetics, health care products, medicines and food fields, but there are several problems in the practical application of green tea extracts: green tea extracts have light , heat instability, and easy to change color under strong acid and strong alkali environment, affecting the appearance of finished products and the bioavailability of green tea extract
[0014] However, due to its perfect crystal structure, such as image 3 As shown, in the actual application process, the majority of scientific researchers have discovered some shortcomings and defects of SLN: the loading of active substances in SLN is generally only 1~5wt%; the particle size of SLN may increase or the activity of degradation and other phenomena; some active substances wrapped in SLN have a burst release effect, that is, they release completely or release most of the active substances in a short period of time.

Method used

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  • Green tea extract nanostructured lipid carrier and preparation method thereof
  • Green tea extract nanostructured lipid carrier and preparation method thereof
  • Green tea extract nanostructured lipid carrier and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A green tea extract nanostructured lipid carrier consisting of 1% green tea extract, 26% caprylic / capric triglyceride + acetylated monoglyceride + butyl octanyl salicylate + butanediol, 17% lauryl Alth-23+Steareth-21+PEG-30 Dipolyhydroxystearate+Polysorbate-80, 1% Steareth-2, 0.6% Butylated Hydroxytoluene+EDTA Sodium composition. The preparation method is as follows:

[0043] Weigh 15g caprylic / capric triglyceride, 5g acetylated monoglyceride, 3g butyl octanyl salicylate, 2g laureth-23, 5g steareth-21, 5g PEG-30 dimer Hydroxystearate, 5g polysorbate-80, 1g steareth-2, 3g butanediol, 0.5g butylated hydroxytoluene, mixed uniformly at 45°C to form a transparent solution, wherein the stirring speed was 300rpm / min, the stirring time is 10min; Weigh 1g of green tea extract and 0.1g of disodium EDTA and add it to 54.4g of 45°C deionized water. It was 300rpm / min, and the stirring time was 5min until the system was uniform; while stirring, it was cooled to room temperature, ...

Embodiment 2

[0045] A green tea extract nanostructured lipid carrier, consisting of 5% green tea extract, 20% glyceryl stearate + butyl octanol salicylate + glyceryl ether-26, 21% PEG-8 caprylic / capric acid Glyceryl esters + polysorbate-80 + polyglyceryl-3 diisostearate + ceteth-25 + PEG-40 stearate, 9% ceteth-6 + ethoxylate Diethylene glycol, 2.5% vitamin E acetate + diethylhexyl syringyl malonate. The preparation method is as follows:

[0046] Weigh 5g glyceryl stearate, 10g butyl octanol salicylate, 5g glycerol polyether-26, 5g PEG-8 caprylic / capric glycerides, 5g polysorbate-80, 3g polyglycerol-3 Diisostearate, 3g Ceteth-25, 5g Ceteth-6, 5g PEG-40 Stearate, 4g Ethoxydiglycol, 2g Vitamin E Acetate, 0.5g Diethylhexyl syringylmalonate was mixed uniformly at 55°C to form a transparent solution, the stirring speed was 350rpm / min, and the stirring time was 15min; 5g of green tea extract was weighed and added to 42.5g of deionized water at 55°C and Stir, the stirring speed is 350rpm / min, a...

Embodiment 3

[0048] A green tea extract nanostructured lipid carrier, consisting of 8% green tea extract, 21% caprylic / capric triglyceride + glyceryl stearate + acetylated monoglyceride + butanediol, 28% stearyl Ether-21+PEG-30 Dipolyhydroxystearate+Polysorbate-80+Ceteth-25+PEG-8 Caprylic / Capric Glycerides+PEG-40 Stearate, 4 %Ceteth-6+Steareth-2, 6.1% vitamin E acetate+butylated hydroxytoluene+diethylhexyl syringylmalonate+disodium EDTA. The preparation method is as follows:

[0049] Weigh 12.5g caprylic / capric triglyceride, 2.5g glyceryl stearate, 3g acetylated monoglyceride, 8g steareth-21, 5g PEG-30 dipolyhydroxystearate, 3g polysorbate Alcohol Esters-80, 3g Ceteth-25, 4g PEG-8 Caprylic / Capric Glycerides, 5g PEG-40 Stearate, 2g Ceteth-6, 2g Steareth-2 , 3g butanediol, 5g vitamin E acetate, 0.5g butylated hydroxytoluene, 0.5 syringyl diethylhexyl malonate were mixed uniformly at 60°C to form a transparent solution, wherein the stirring speed was 400rpm / min, stirring The time is 10min;...

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Abstract

The invention provides a green tea extract nanostructured lipid carrier and a preparation method thereof. The green tea extract nanostructured lipid carrier is prepared from green tea extract, lipid, emulsifiers, co-emulsifiers, stabilizers and deionized water according to a specific mass percentage. The preparation method includes (1) taking the lipid, the emulsifiers, the co-emulsifiers and the stabilizers as oil phases, and uniformly mixing at the temperature of 40-60 DEG C to form a mixed solution; (2) adding a green tea extract contained deionized water solution as same as the mixed solution in temperature while stirring uniformly; (3) cooling to the room temperature while stirring so as to obtain the brown green tea extract nanostructured lipid carrier. The green tea extract nanostructured lipid carrier and the preparation method thereof have the advantages that the NLC (nanostructured lipid carrier) is used for wrapping the green tea extract, so that stability of the green tea extract under light, heat and pH value conditions is improved, and the green tea extract can be matched with cosmetic formulations optionally to give full play to oxidation resistance, anti-aging and skin improvement.

Description

technical field [0001] The invention relates to a carrier system in cosmetic preparation technology, in particular to a green tea extract nanostructured lipid carrier and a preparation method thereof. Background technique [0002] Green tea extract mainly includes tea polyphenols (catechins), etc., which have antioxidant and free radical scavenging effects. Tea Polyphenols (TeaPolyphenols), also known as anti-oxidant, vitamin phenol, and anti-haring, is the general term for polyphenols in tea, and it is also one of the main components that form the color, fragrance, and health care functions of tea. The main chemical components are A complex of compounds such as catechins (flavanols), flavonoids and flavonols, anthocyanins, phenolic acids and phenolic acids, and polymerized phenols, among which catechins are tea polyphenols The main component accounts for 65%-80% of the total amount of tea polyphenols. Catechin compounds mainly include catechin (EC), gallocatechin (EGC), c...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/97A61Q19/08
CPCA61K8/14A61K8/97A61K2800/413A61Q19/08
Inventor 夏强
Owner 苏州纳康生物科技有限公司