Method for preparing nanoscale pesticide preparation by means of silicon dioxide aerogel

A silicon dioxide and pesticide preparation technology, applied in the field of pesticides, can solve the problems of difficulty in achieving high drug loading, large specific surface area and stable quality, low content of main drugs, and inability to achieve, saving equipment investment and maintenance costs, The effect of long stabilization time, increased production cost and labor cost

Inactive Publication Date: 2016-03-02
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the existing traditional excipients are mostly solid granules, and there is no small-scale space structure to accommodate the drug. Most of them load the drug molecules on the surface of the fine solid structure, so that a high drug loading capacity cannot be achieved, and the main drug is often formed. Small-scale mixtures with low drug content and large amounts of excipients are difficult to meet the basic requirements of high drug loading, large specific surface area and stable quality

Method used

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  • Method for preparing nanoscale pesticide preparation by means of silicon dioxide aerogel
  • Method for preparing nanoscale pesticide preparation by means of silicon dioxide aerogel
  • Method for preparing nanoscale pesticide preparation by means of silicon dioxide aerogel

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Preparation technology of nano-scale abamectin drying

[0038] 1 Drug dissolution and adsorption drug loading

[0039] 1.1 Precisely weigh 250 grams of Abamectin original drug

[0040] 1.2 Precisely weighed silica aerogel 250g

[0041] 1.3 Measure 500 ml of solvent ethyl acetate (analytical grade), dissolve it into a light yellow clear liquid, add 1500 ml of absolute ethanol (analytical grade) to dilute.

[0042] 1.4 Add 250 g of aerogel until the drug solution is completely adsorbed.

[0043] 2 Nanodispersion or Microsphere Preparation

[0044] 2.1 The obtained drug carrier was placed in a beaker, and 2000 ml of absolute ethanol was added.

[0045] 2.2 Emulsification by high-speed emulsifying machine, parameters: rotating speed 10000 rpm, time 5 minutes.

[0046] 2.3 Use a drying oven to dry the emulsion, parameters: temperature 100°C, time 12 hours.

[0047] 2.4 Pulverize the semi-finished product through a 200-mesh sieve to obtain nano-avermectin powder.

Embodiment 2

[0049] Nanometer methylamino abamectin benzoate (carboxylate) drying preparation technology

[0050] 1 Drug dissolution and adsorption drug loading

[0051] 1.1 Precisely weighing 250 grams of the original drug of methylamino abamectin benzoate

[0052] 1.2 Precisely weighed silica aerogel 250g

[0053] 1.3 Weigh 7g of D902 anti-decomposition agent (Shenzhen Langtai Biotechnology Co., Ltd.), measure 2000 ml of solvent absolute ethanol (analytical grade), and prepare an alcohol solution with a concentration of 0.35%.

[0054] 1.4 Add the above alcohol solution to dissolve the original drug of Avermectin Benzoate to a brown clear liquid.

[0055] 1.4 Add 250 g of aerogel until the drug solution is completely adsorbed.

[0056] 2 Nanodispersion or Microsphere Preparation

[0057] 2.1 The obtained drug carrier is placed in a beaker, 2000 ml of purified water is added, and the mixture is stirred.

[0058] 2.2 Emulsifying by high-speed emulsifying machine, parameters: rotating ...

Embodiment 3

[0062] Preparation technology of nanometer ivermectin drying

[0063] 1 Drug dissolution and adsorption drug loading

[0064] 1.1 Precisely weigh 250 grams of ivermectin original drug

[0065] 1.2 Precisely weighed silica aerogel 250g

[0066] 1.3 Measure 2000 ml of solvent anhydrous ethanol (analytical grade) and dissolve it into a light yellow clear liquid.

[0067] 1.4 Add 250 g of aerogel until the drug solution is completely adsorbed.

[0068] 2 Nanodispersion or Microsphere Preparation

[0069] 2.1 The obtained drug carrier is placed in a beaker, 2000 ml of purified water is added, and the mixture is stirred.

[0070] 2.2 Emulsifying by high-speed emulsifying machine, parameters: rotating speed 28000 rpm, time 5 minutes.

[0071] 2.3 Use a drying oven to dry the emulsion, parameters: temperature 120°C, time 12 hours.

[0072] 2.4 Pulverize the semi-finished product through a 200-mesh sieve to obtain nanometer ivermectin powder.

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Abstract

The invention discloses a method for preparing a nanoscale pesticide preparation by means of silicon dioxide aerogel, belongs to the technical field of pesticides, and particularly relates to the application of silicon dioxide aerogel serving as a novel carrier of a pesticide processing aid. According to the technical scheme, when the silicon dioxide aerogel is used for nanocrystallized preparation processing of a slightly soluble technical material as a carrier, the technical material is dissolved in a solvent or broken, the silicon dioxide aerogel is loaded with liquid containing the solvent through adsorption or mixed with the broken technical material so as to form a nanoparticle drug carrier system with the diameter smaller than 100 nm, water is added to the nanoparticle drug carrier system, stirring or emulsification is conducted for homogenous dispersion, the solvent and water are removed through drying, and then a nanoscale pesticide is obtained. The method has the advantages that environment friendliness is realized, and the gap in the carrier material for nanoscale pesticides at home and abroad is filled.

Description

technical field [0001] The invention belongs to the technical field of pesticides, and specifically refers to the application of silica aerogel as a novel carrier in pesticide processing aids. Background technique [0002] Pesticide refers to a class of drugs that kill insects, sterilize and kill harmful animals (or weeds) in order to protect and promote the growth of plants and crops in agricultural production. In particular, it is used in agriculture to control pests and diseases, regulate plant growth, and weed control. Pesticides play an important role in ensuring the yield and quality of agricultural products and ensuring human food security. High-efficiency, low-toxicity, low-residue, economical and easy-to-use high-quality pesticide varieties should be the direction of pesticide development. [0003] In the actual production and application of pesticides, although the production and sales of organophosphorus highly toxic pesticides have been banned and restricted, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/14A01N43/90A01N43/54A01N53/08A01P7/04
CPCA01N25/14A01N43/54A01N43/90A01N53/00
Inventor 张旭旭张志安伍超
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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