Bone repair material with multi-dimensional channel structure

A channel structure and bone repair technology, applied in the field of biomedical materials, can solve the problems of poor pore permeability, small pore size, and low mechanical properties of artificial bone repair materials, and achieve good mechanical transmission, high strength, and good structural stability Effect

Inactive Publication Date: 2016-03-09
宋占涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the defects of low mechanical properties, small pore diameter and poor pore permeability of the artificial bone repair material, the present invention provides an artificial bone repair material with a multi-dimensional channel structure, which is realized by the following scheme:

Method used

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  • Bone repair material with multi-dimensional channel structure
  • Bone repair material with multi-dimensional channel structure
  • Bone repair material with multi-dimensional channel structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Bone repair material preparation

[0060] Step 1 Prepare the base material

[0061] Weigh 50g of mineralized collagen material (water content is 80%), add ceramic powder 2g therein, stir clockwise with the rotating speed of 100rpm, adjust the pH value to 7.0 with 1.0M phosphoric acid solution and 1.0M sodium hydroxide lye, Then adjust the pH value to 7.2 with 0.5M sodium carbonate solution, and the conductivity is 1.5ms / cm. Stand still for 30 minutes, then centrifuge at 10000rpm at 4°C for 30 minutes to remove the supernatant. Add Staphylococcus aureus fermentation liquid filtrate to the precipitation, make the coagulation enzyme activity be 1600 μ g / g, add 37.5g collagen material (the purity of collagen is 40mg / g), continue to stir uniformly in the same direction, and adjust the precipitation to make the composite mineral The pH value of the collagen matrix is ​​7.2, and the conductivity is 3.0ms / cm. At greater than 1.01×10 2 Degas under Pa vacuum conditions, and t...

Embodiment 2

[0074] Step 1 Prepare the base material

[0075] Weigh 65g mineralized collagen material (water content is 80%), add ceramic powder 2g therein, stir clockwise with the rotating speed of 100rpm, then adjust the pH value to 7.0 with 1.0M phosphoric acid solution and 1.0M sodium hydroxide lye , and then adjust the pH value to 7.2 with 0.5M sodium carbonate solution, and the conductivity is 1.5ms / cm. Stand still for 30 minutes, then centrifuge at 10000rpm at 4°C for 30 minutes to remove the supernatant. Add Staphylococcus aureus fermentation liquid filtrate to the precipitate to make the coagulase activity 3200 μg / g, add 75g of collagen material (the purity of collagen is 40mg / g), continue to stir evenly in the same direction, and adjust the precipitate to make the composite mineralization The pH of the collagen matrix is ​​7.2 and the conductivity is 3.0ms / cm. At greater than 1.01×10 2 Degas under Pa vacuum conditions, and then continue to use 1.0M phosphoric acid solution and...

Embodiment 3

[0088] Step 1 Prepare the base material

[0089] Take by weighing 50g mineralized collagen material (water content is 80%), add ceramic powder 1g wherein, stir clockwise with the rotating speed of 100rpm, then adjust the pH value to 7.0, then adjust the pH value to 7.2 with 0.5M sodium carbonate solution, and the conductivity is 1.5ms / cm. Stand still for 30 minutes, then centrifuge at 10000rpm at 4°C for 30 minutes to remove the supernatant. Add Staphylococcus aureus fermentation liquid filtrate to the precipitate to make the coagulase activity 1600 μg / g, add 75g of collagen material (the purity of collagen is 40mg / g), continue to stir evenly in the same direction, and adjust the precipitate to make the complex mineralization The pH of the collagen matrix is ​​7.2 and the conductivity is 3.0ms / cm. At greater than 1.01×10 2 Degas under Pa vacuum conditions, and then continue to adjust with 1.0M phosphoric acid solution and 1.0M sodium hydroxide lye solution to make the condu...

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Abstract

The invention discloses a bone repair material with a multi-dimensional channel structure. The bone repair material has a layered matrix structure; a plurality of bosses I are formed in one surface of the matrix structure, and a plurality of bosses II are formed in another surface of the matrix structure; the bosses I and the bosses II are arrayed alternatively; grooves are formed between adjacent bosses I and adjacent bosses II; and a plurality of through holes are formed in a way of being perpendicular to the surfaces of the bosses I. The bone repair material provided by the invention adopts a three-dimensional network channel formed through the through holes in the matrix structure and the grooves, and the three-dimensional network channel is filled with collagenous fiber, which is favorable for cell attachment and growth as well as nerve ingrowth, and also is convenient for nutrient substance transfer and cell metabolite discharge, and also can enable cells to be evenly distributed in the interior of the material, and is favorable for even and uniform organizational formation in the interior of a support; the structural material can form firm biological gomphosis with regenerated new bone, and good structure stability can be maintained during a degradation process; the mechanical strength is high, and mechanical transmission between a bone defect part and normal bone tissue can be well achieved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a clinically applied bone repair material, in particular to a bone repair material with enhanced strength, multi-dimensional porous, and slow-release therapeutic effect. Background technique [0002] Bone defect is a very common disease in clinical practice, but the repair of bone defect is still a difficult problem in orthopedic clinics. Although scientific and technological workers have done a lot of work in the research and preparation of clinical bone repair materials over the years, great progress has been made. But there should be many problems. [0003] The bone quality of natural bone is divided into compact bone and cancellous bone according to the arrangement of the bone plates and the density of the spatial structure. The ordered anisotropic structure mainly meets the needs of its mechanical properties. Bone tissue is mainly a composite material with a porous struct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61L27/42A61L27/54A61L27/56
CPCA61F2/28A61F2002/30003A61F2002/30199A61F2002/30385A61L27/425A61L27/427A61L27/54A61L27/56A61L2300/30A61L2300/412A61L2430/02
Inventor 宋占涛
Owner 宋占涛
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