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A kind of preparation method of self-curing high-strength macromolecular glue

A high-strength, macromolecular technology, used in biomedicine, structural engineering, and chemical engineering, can solve the problems of limited application range, weak hydrogel, poor mechanical properties, etc., and achieve low cost, abundant sources, and high viscosity.

Active Publication Date: 2019-02-19
BEIJING VANJEWEL MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the macromolecular colloids disclosed by these inventions have injectability, biocompatibility and degradability, and some progress has been made in self-curing, hydrogels are usually fragile, have high water content, and poor mechanical properties. , which greatly limits its scope of application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Add 0.4g of cornstarch to 1.6ml of deionized water, stir until completely dissolved at 50-60°C to form a uniform solution with a viscosity of 64800mPa·s, add tetracalcium phosphate and anhydrous diphosphate in 0.6 times the volume Hydrogen-calcium mixed powder, stir again until a soft, injectable colloidal composite material is formed, fill the viscous colloid into a syringe, inject it into a watch glass, and form a strip-shaped green body material, place it at room temperature, and find It can harden and self-cure after 18 minutes; if it is directly injected into water, it will solidify and form a hard sample after 25 minutes at room temperature.

[0031] If it is directly injected into a sample with a crack, it is injected at the crack and placed at room temperature, and it is found that the composite glue can penetrate deep into the crack. After 30 minutes, the colloid sample solidifies, fills the crack well, and cures. After that, it can withstand higher mechanical ...

Embodiment 2

[0034] Add 0.5g of polyglutamic acid to 2ml of citric acid aqueous solution, stir at room temperature until completely dissolved to form a uniform solution with a viscosity of 4560mPa s, add tricalcium phosphate, tetracalcium phosphate, chlorine Calcium chloride and calcium dihydrogen phosphate dihydrate mixed powder, stir again to form a soft, injectable colloid composite material, fill the viscous colloid into a syringe, inject it into a watch glass, and form a long strip of soft billet If it is placed at room temperature, it will be self-cured and hardened after 35 minutes; if it is directly injected into water, after 120 minutes, the strip body will solidify and form a hard sample.

[0035] Inject the colloidal composite material into a stainless steel mold of 6mm*12mm (diameter*height), and demould after 20 minutes. After the curing is complete, the upper and lower surfaces are polished smooth and parallel, and the compression test is carried out on a uniaxial mechanical t...

Embodiment 3

[0037] Add cornstarch and polyglutamic acid (0.1g and 0.1g respectively) into 1.98ml of sodium dihydrogen phosphate aqueous solution, stir at 45-60°C until completely dissolved to form a uniform solution with a viscosity of 350mPa s, add tricalcium phosphate and hydroxyapatite mixed powder with 0.75 times the volume, stir again until a soft, injectable colloidal composite material is formed, fill the viscous colloid into a syringe, and inject it into a watch glass, Form a long strip of soft green body, place it at room temperature, and find that it can be self-cured after 35 minutes; if it is directly injected into water, place it at room temperature, place it in a shaker, shake it at a speed of 0-500rpm, and find that the green body can maintain Good integrity without unraveling, and after 70 min, the strips of the green body solidified to form a hard sample.

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Abstract

The invention discloses a method for preparing self-curing high-strength macromolecular glue. The method comprises the following steps: dissolving starch or polyglutamic acid bio-macromolecules into water or an aqueous solution; uniformly mixing to form a flowable colloid; adding phosphomycin calcium powder; stirring uniformly to a viscous state in order to obtain a target product. The method is simple in process, has no equipment and technical requirements, is rich in raw material source, and is low in cost. Moreover, the bio-macromolecules have biological safety and biodegradability, and are environmentally friendly and nontoxic, so that the prepared composite material colloid has viscosity, injection property and biological degradability, is prevented from being scattered easily in liquid, and has self-curing performance, high strength and the like. The macromolecular glue can be used for filling and repairing various cracks and gaps under load-bearing and non-load-bearing conditions, and filling, repairing and supporting medical soft tissues and hard tissues.

Description

technical field [0001] The invention belongs to the fields of chemical engineering, biomedicine and structural engineering, and relates to a preparation method of self-curing high-strength macromolecular glue. Background technique [0002] Macromolecular colloid is a polymer gel with water as the dispersion medium. It has a three-dimensional network cross-linked structure, good fluidity and injection filling properties. When it is filled to the required position, it is easy to The flow fills the entire defect site and plays a good repairing role. In particular, the gel-like mixture with self-curing properties can play a good role in filling and fixing after the glue is cured. Biomacromolecules have good biocompatibility and degradation properties, can be used in the field of biomedicine, and can be used as carriers of drugs or cells. After injection or filling into the defect site, it can promote tissue growth and repair, especially for Injection surgery has less surgical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L3/02C08L77/04C08K3/32C08K3/16C08K3/30A61L31/04A61L31/06A61L31/02A61L31/14
CPCA61L31/028A61L31/042A61L31/06A61L31/148A61L2300/112A61L2300/232A61L2300/412A61L2300/604A61L2400/06A61L2430/02A61L2430/12C08J3/075C08J2303/02C08J2377/04C08K3/16C08K3/30C08K3/32C08K2003/162C08K2003/3045C08K2003/325C08K2201/014C08L3/02C08L77/04C08L2201/06C08L2203/02
Inventor 刘慧玲杨磊高春霞白艳洁杨惠林
Owner BEIJING VANJEWEL MEDICAL TECH CO LTD
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