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A kind of molecularly imprinted polymer and its preparation method and application

A molecular imprinting and polymer technology, applied in the field of analytical chemistry, can solve the problems of impurity interference detection, low specificity of adsorbents, etc., and achieve the effect of high recovery rate, high selectivity and strong specificity

Active Publication Date: 2019-03-26
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the problems in the prior art that the adsorbents used in the pretreatment process of the detection sample of Brilliant Tibetan Flower Essence are not strong in specificity and are easy to introduce impurities to interfere with the detection, the present invention provides a molecularly imprinted polymer and its preparation method and application

Method used

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  • A kind of molecularly imprinted polymer and its preparation method and application
  • A kind of molecularly imprinted polymer and its preparation method and application
  • A kind of molecularly imprinted polymer and its preparation method and application

Examples

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Embodiment 1

[0031] Dissolve 0.5mmol of saponin, 2mmol of p-vinylbenzoic acid, 10mmol of divinylbenzene, and 0.05mmol of azobisisobutyronitrile in 20mmol of acetonitrile, mix well in a round-bottomed flask, and pass nitrogen at 0°C Deoxygenation for 0.5h, ultrasonic pretreatment for 0.5h; seal with a rubber stopper, react at a constant temperature of 60°C for 24 hours to obtain a polymer product; grind the polymer product, rinse with acetone to remove fine particles, and sieve to make the particle size of the polymer product at 20 -200μm; using 200mL methanol solution of formic acid (1:10, V:V) as the extractant, Soxhlet extraction for 24h to remove the crocus, add 200mL methanol solution of formic acid (1:10, V :V), washing with 100mL of methanol after the extraction, and then removing residual formic acid by filtration; drying the molecularly imprinted polymer from which crocin quince was removed in vacuum at 60° C. for 12 hours to obtain a molecularly imprinted polymer with crocin bloom....

Embodiment 2

[0033] Dissolve 1mmol of saponifera essence, 2mmol of methyl methacrylate, 10mmol of ethylene glycol bismethacrylate, and 0.1mmol of azobisisobutyronitrile in 20mmol of acetonitrile, mix well in a round-bottomed flask, and store at 0°C Nitrogen deoxygenation under nitrogen for 0.5h, ultrasonic pre-action for 0.5h; use rubber stopper to seal, 60 ℃ constant temperature reaction for 24 hours to obtain the polymer product; grind the polymer product, rinse with acetone to remove fine particles, and sieve to make the particle size of the polymer product At 20-200μm; using 200mL methanol solution of formic acid (1:10, V:V) as the extractant, Soxhlet extraction for 24h to remove the safflower sperm molecule, the middle 12h to add 200mL methanol solution of formic acid (1:10, V :V), washing with 100 mL of methanol after the extraction was completed, and removing residual formic acid by filtration; drying the molecularly imprinted polymer from which crocetin was removed in vacuum at 60° ...

Embodiment 3

[0035]Grind and sieve the molecularly imprinted polymer of crocodile sperm produced in Example 1, and extract with the extractor shown (extraction liquid is methanol-acetic acid with a volume of 9:1) until no croceflower sperm molecules can be detected, After washing away the residual solution with methanol, vacuum-dry at 60° C. overnight, and evenly fill the polymer particles in the elution column. Spray 1mL saffron-methanol solution (concentration: 30μg / g) on ​​the surface of 1g shrimp skin, let it stand overnight, use 5mL acetonitrile to ultrasonically extract for 10min, centrifuge to get the supernatant, repeat the extraction of the residue twice, and combine the extracts. The extract was added to the elution column, and the supernatant was separated from the adsorbent after standing for adsorption for 12 hours. Use 2mL methanol solution to ultrasonically elute the adsorbent, and the eluent is filtered through a 0.22 μm organic filter membrane, and then detected by high pe...

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Abstract

The present invention relates to a molecularly imprinted polymer, a preparation method and applications thereof, wherein brilliant crocein is adopted as a template molecule, the brilliant crocein, a functional monomer, a cross-linking agent and a pore forming agent are polymerized in the presence of an initiator to obtain a polymerization product, and the brilliant crocein is removed in the polymerization product is removed to prepare the molecularly imprinted polymer. According to the present invention, with the application of the molecularly imprinted polymer adopted as the brilliant crocein adsorption material in the solid phase extraction, the selective adsorption of the brilliant crocein in the complex sample can be improved while other impurities are not introduced; and the molecularly imprinted polymer can be used for separation and detection of the brilliant crocein in dried shrimp and other complex matrixes, and has characteristics of strong specificity and high recovery rate.

Description

technical field [0001] The invention belongs to the technical field of analytical chemistry, and in particular relates to a molecularly imprinted polymer and its preparation method and application. Background technique [0002] Crocein Scarlet 3B, also known as acid red 73 (Brilliant crocein), is an azo-yellow red dye containing a benzene ring, which is moderately toxic and highly carcinogenic. The main uses are the dyeing of wool silk fabrics, the coloring of paper, plastic, wood, spices, medicine, anodized aluminum and cement, and it is also used to make ink; it is a kind of dye that is prohibited from being added and used in food processing by the state. However, in recent years, some unscrupulous traders have used acid red 73 as a food additive dye, and added it repeatedly during the processing of dried shrimp, so that the dried shrimp has a ruddy color, and it will not fade after long-term storage. [0003] At present, there is no literature report on the detection met...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F212/36C08F212/14C08F222/14C08F220/14C08J9/28B01J20/26B01J20/30
Inventor 文倩孙姝琦张颖姚青王红
Owner CHINA PETROLEUM & CHEM CORP
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