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Rhizoma anemarrhenae effective part as well as preparation method and application thereof

A technology of effective parts and Anemarrhena, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems that the extracts have not been successfully developed into drugs, etc., to improve the glucose tolerance of rats and have strong effects , significant effect

Inactive Publication Date: 2016-06-15
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although a variety of Anemarrhena extracts with hypoglycemic effects have been reported in the prior art, due to various reasons, these extracts have not been successfully developed into medicines.

Method used

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  • Rhizoma anemarrhenae effective part as well as preparation method and application thereof
  • Rhizoma anemarrhenae effective part as well as preparation method and application thereof
  • Rhizoma anemarrhenae effective part as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation of the effective part of Anemarrhena:

[0043] S1. Grinding Anemarrhena anemarrhena with 80% ethanol volume fraction and extracting twice by reflux, 1 hour each time, the ratio of the amount of ethanol to the amount of raw material Anemarrhena anemarrhena is 8mL: 1g; filter, and concentrate the filtrate until there is no ethanol smell, known mother extract;

[0044] S2. Add water to dissolve, adjust the relative density of Anemarrhena extract to 1.045-1.055 (40-45°C), apply macroporous resin for adsorption, and the sample loading flow rate is 1BV / h; after the sample is loaded, use 5BV of water to elute and remove impurities , the flow rate is 1BV / h; it is 60% ethanol elution with 6BV volume fraction again, and the flow rate is 0.5BV / h; collect the ethanol eluent, and after concentrating and drying, the parent effective part is known; the consumption of macroporous resin is 1L macroporous resin for dry extract of Anemarrhena anemarrhena extract prepared in 0...

Embodiment 2

[0053] Preparation of the effective part of Anemarrhena:

[0054] S1. Grinding Anemarrhena anemarrhena with 80% ethanol and refluxing extraction twice, 1 hour each time, the ratio of the amount of ethanol to the amount of raw material Anemarrhena anemarrhena is 10mL: 1g; filter, and concentrate the filtrate until there is no ethanol smell, known mother extract;

[0055] S2. Add water to dissolve, adjust the relative density of Anemarrhena extract to 1.045-1.055 (40-45°C), apply macroporous resin for adsorption, and sample loading flow rate is 1.5BV / h; after sample loading, wash with 3BV of water to remove Miscellaneous, flow rate is 1.5BV / h; It is 70% ethanol eluting with 6BV volume fraction again, and flow rate is 1BV / h; Collect ethanol eluate, promptly know parent effective part after concentrating and drying; The consumption of macroporous resin is For every 0.4kg of dry extract of the Anemarrhena anemarrhena extract prepared in step S1, 1L of macroporous resin was used. ...

Embodiment 3

[0058] Preparation of the effective part of Anemarrhena:

[0059] S1. Grinding Anemarrhena anemarrhena with 80% ethanol volume fraction and extracting twice by reflux, 1 hour each time, the ratio of the amount of ethanol to the amount of raw material Anemarrhena anemarrhena is 8mL: 1g; filter, and concentrate the filtrate until there is no ethanol smell, known mother extract;

[0060] S2. Add water to dissolve, adjust the relative density of Anemarrhena extract to 1.045-1.055 (40-45°C), apply macroporous resin for adsorption, and sample loading flow rate is 0.5BV / h; after sample loading, wash with 5BV of water to remove miscellaneous, the flow rate is 0.5BV / h; then elute with 5BV volume fraction of 60% ethanol, the flow rate is 0.5BV / h; collect the ethanol eluate, concentrate and dry to know the effective part of the mother; the amount of macroporous resin Use 1L macroporous resin for every 0.2kg dry extract of Anemarrhena extract prepared in step S1.

[0061] As a result, t...

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Abstract

The invention relates to the technical field of traditional Chinese medicines and in particular discloses a rhizoma anemarrhenae effective part as well as a preparation method and application thereof. The rhizoma anemarrhenae effective part mainly contains rhizoma anemarrhenae total saponins, and main ingredients of the rhizoma anemarrhenae total saponins are rhizoma anemarrhenae saponin BII, rhizoma anemarrhenae saponin BIII and a rhizoma anemarrhenae saponin BIII isomer. Experimental results show that the rhizoma anemarrhenae effective part can obviously improve the sugar tolerance of a diabetic rat at different time points, enhance the insulin sensitivity of a type-II diabetic rat and improve the hyperlipidemia state of the type-II diabetic rat.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an effective part of Zhimu and its preparation method and application. Background technique [0002] Anemarrhena anemarrhena is the dry rhizome of Anemarrhena asphodeloides Bge, a plant of the Liliaceae family. It tastes bitter and cold in nature, and it returns to the lung, stomach, and kidney channels. It is mainly used to treat febrile disease, high fever and polydipsia, cough and asthma, dry cough, constipation, bone steaming and hot flashes, restlessness and insomnia, thirst and stranguria, etc. For decades, scholars at home and abroad have carried out extensive and in-depth research on the chemical components of Anemarrhena, and found that Anemarrhena is rich in steroidal saponins, biliprazones, flavonoids, lignans, polysaccharides, β-sitosterol, fatty oil, tannic acid, pantothenic acid, choline, a large amount of mucus and trace elements, etc. Modern...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P3/10A61P3/06A61P5/50
CPCA61K36/8964A61K2236/333A61K2236/39A61K2236/55
Inventor 钟艳梅冯毅凡孟青钟静君
Owner GUANGDONG PHARMA UNIV
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