Optical three-mode targeted contrast agent for lung non-cellule cancer as well as preparation method and application thereof

A non-small cell cancer, targeted contrast agent technology, applied in the direction of X-ray contrast agent preparation, general/multifunctional contrast agent, pharmaceutical formulations, etc., can solve the problem of non-small cell carcinoma of the lung not found in contrast performance and other issues
CN105879062AActive Publication Date: 2016-08-24SHANGHAI FIRST PEOPLES HOSPITAL +1
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
SHANGHAI FIRST PEOPLES HOSPITAL
Publication Date
2016-08-24

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Abstract

The invention relates to a CT / MR / near infrared optical three-mode targeted contrast agent based on the lung non-cellule cancer as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, modifying the amino terminal of a fifth-generation polyamide-amine dendrimer with DOTA-NHS; secondly, connecting folic acid to the dendrimer by polyethylene glycol; thirdly, further modifying with Cy5.5; fourthly, preparing gold nanoparticles by using the modified dendrimer as a template through sodium borohydride reduction, and chelating gadolinium ions to the dendrimer; fifthly, carrying out complete acetylization on amino remained on the surface of the dendrimer; and finally, dialyzing the reacted solution, lyophilizing to obtain a final product, and evaluating in-vivo and in-vitro CT / MR / near infrared optical three-mode contrast performance of the product. The method is simple and feasible, has excellent in-vivo and in-vitro lung non-cellule cancer cell target effect, and has a potential application prospect of targeted CT / MR / near infrared optical contrast.
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Description

technical field

[0001] The invention belongs to the field of preparation of contrast agents, in particular to a method for preparing a Cy5.5-Gd-Au DENPs-FA-based three-mode targeting contrast agent for lung non-small cell carcinoma CT / MR / near-infrared optics. Background technique

[0002] In research and clinical applications, many imaging modalities have been widely used, such as CT, MR, near-infrared optical imaging, PET, SPECT. Among these modalities, CT offers better spatial and density resolution than other imaging modalities, and MR imaging offers superior soft-tissue contrast, high spatial resolution, and flexible sectioning capabilities. Although optical imaging is inferior in resolution to CT or MR, optical imaging provides good detection sensitivity. Since these imaging modes have their own advantages and disadvantages, the joint application of these modes will get more ideal results.

[0003] Nanomedicine opens a new avenue for molecular imaging, which can provi...

Claims

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