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Preparation method of alginate hydrogel dressing

A hydrogel, alginic acid technology, applied in medical science, bandages and other directions, can solve the problems of damage to the integrity of the dressing, unfavorable wound dressing change and treatment, fragmentation, etc., and achieve the effect of good biocompatibility and healing.

Active Publication Date: 2016-10-12
武汉沃德利派医疗器械有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method, on the one hand, will make the formed hydrogel brittle and brittle due to the single calcium ion cross-linking; on the other hand, the calcium alginate formed by cross-linking in the hydrogel will Calcium ions will ion-exchange with sodium ions in blood or wound exudate, and its hydrogel will be re-dissolved due to calcium alginate becoming water-soluble sodium alginate, and the integrity of the dressing will be destroyed or even broken. Facilitate wound dressing change and treatment

Method used

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preparation example Construction

[0020] A preparation method of alginic acid hydrogel dressing, the preparation method is carried out according to the following steps:

[0021] a. Preparation of maleylated sodium alginate

[0022] Put sodium alginate powder and maleic anhydride in an aprotic solvent, the mass volume ratio of sodium alginate to aprotic solvent is 1:10-200, and the molar ratio of hydroxyl groups on the molecular chain of sodium alginate to anhydride groups of maleic anhydride is 1: 0.1-10, stir evenly at room temperature, react at 25-90°C, the reaction time is 12-48 hours, after the reaction, add to the mixed solution formed by sodium alginate, maleic anhydride and aprotic solvent Anhydrous acetone until no precipitation occurs in the mixed solution, collect the precipitate, and vacuum-dry the precipitate at room temperature for 2 days to obtain maleylated sodium alginate with a molar substitution of 0.03 to 0.8; the aprotic solvent is dimethyl One of methyl formamide or dimethylacetamide or d...

Embodiment 1

[0030] Weigh 5g of sodium alginate powder and 0.5g of maleic anhydride, add them to 50mL of dimethylformamide, stir well at room temperature, and react at 25°C for 12 hours. After the reaction, add anhydrous acetone until no precipitation occurs The precipitate was collected and dried in vacuum at room temperature for 2 days to obtain maleoylated sodium alginate with a molar substitution of 0.03.

[0031] Weigh 5g of maleylated sodium alginate, put it in 50mL of deionized water, stir until completely dissolved, add 0.25g of 2-hydroxy-2-methyl-1-p-hydroxyethyl ether phenylacetone, at a wavelength of 320-480nm, light intensity 5mW / cm 2 Irradiate under ultraviolet light for 1 min to obtain maleylated sodium alginate hydrogel, freeze-dry at -75°C for 48 hours to form maleylated sodium alginate sponge, place the sponge in 0.1mol / L CaCl 2 In the solution, stand at room temperature for 0.1 h to form a maleylated sodium alginate hydrogel with an equilibrium swelling degree of 0.2, an...

Embodiment 2

[0033] Weigh 5g of sodium alginate powder and 50g of maleic anhydride, add them to 1000mL of dimethylacetamide, stir well at room temperature, and react at 90°C for 48 hours. After the reaction, add anhydrous acetone until no precipitation occurs , collected the precipitate, and dried it in vacuum at room temperature for 2 days to obtain maleoylated sodium alginate with a molar substitution of 0.8.

[0034] Weigh 5g of maleylated sodium alginate, put it in 500mL deionized water, stir until completely dissolved, add 5g of 1-hydroxycyclohexyl phenyl ketone, at a wavelength of 320-480nm and a light intensity of 100mW / cm 2 Irradiate under ultraviolet light for 20 minutes to obtain maleylated sodium alginate hydrogel, freeze-dry at -75°C for 48 hours to form maleylated sodium alginate sponge, place the sponge in 1mol / L ZnCl 2 The solution was allowed to stand at room temperature for 5 hours to form a maleylated sodium alginate hydrogel with an equilibrium swelling degree of 0.01, w...

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Abstract

The invention relates to a preparation method of a hydrogel dressing and in particular relates to a preparation method of an alginate hydrogel dressing, belonging to the technical field of preparation of a medical dressing. According to the preparation method provided by the invention, maleylated sodium alginate is synthesized, and processes of dissolving, ultraviolet illumination, freeze-drying, soaking and the like are carried out to form a double-crosslinking three-dimensional net structure with light crosslinking and ion crosslinking existing simultaneously, wherein the net structure of the ion crosslinking part is the alginate hydrogel dressing capable of being dissociated. The preparation method provided by the invention fully exerts the synergistic effects of chemical crosslinking and ion crosslinking, so that the dressing is endowed with good wet strength, toughness and elasticity. The alginate hydrogel dressing prepared by the preparation method has good biocompatibility and can not cause any damage to a wound when being applied to the wound, thereby being favorable for healing of the wound.

Description

technical field [0001] The invention relates to a preparation method of a hydrogel dressing, in particular to a preparation method of an alginic acid hydrogel dressing, and belongs to the technical field of preparation of medical dressings. Background technique [0002] Hydrogel dressing is a polymer gel with a three-dimensional network structure that is superior to traditional gauze dressings. It is mainly formed by cross-linking hydrophilic polymers through physical or chemical actions. When it acts on the wound surface, it can debride and absorb the wound surface. Exudate, providing a moist healing environment to accelerate wound healing. Sodium alginate hydrogel dressing is a hydrogel dressing formed based on natural polymer alginic acid. In addition to the advantages of hydrogel dressing, it also gives full play to the excellent characteristics of alginic acid, such as natural non-toxic, hemostatic, anti Bacteria, promote wound healing, etc. [0003] At present, the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J9/28C08J3/075C08J3/28C08J3/24C08L5/04
CPCA61L26/0023A61L26/0085C08J3/075C08J3/24C08J3/28C08J9/28C08J2201/0484C08J2305/04C08L5/04
Inventor 周应山董齐张灿殷先泽杨红军柏自奎顾绍金陶咏真徐卫林
Owner 武汉沃德利派医疗器械有限公司
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