Curcumin-loaded collagen-PCL-PVP composite micro-nano fiber membrane and preparation method thereof

A technology of curcumin and fiber membrane, applied in synthetic fibers, fiber types, fiber processing and other directions, can solve the problems of incomplete retention of triple helix structure, limit medical applications, reduce biological activity, etc. Smooth surface and uniform diameter

Active Publication Date: 2016-10-26
SICHUAN UNIV
View PDF4 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the preparation of tissue engineering scaffolds by electrospinning collagen has attracted increasing attention. However, it has been found that the three-stranded helical structure of collagen can not be completely preserved in the commonly used electrospin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Curcumin-loaded collagen-PCL-PVP composite micro-nano fiber membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of curcumin-loaded PCL-PVP composite micro-nano fiber membrane by electrospinning: Mix dichloromethane and ethanol in a certain volume ratio to prepare an electrospinning mother liquor, in which the volume percentage of dichloromethane is 50% ; Then blend PCL and PVP in a mass ratio of 4:1, stir at room temperature until transparent, prepare a mixed solution with a mass concentration of 6%, and then add a concentration of 5 mg / ml to the above-mentioned PCL-PVP mixed solution Curcumin, stir rapidly at room temperature until completely dissolved to obtain the electrospinning mother liquor, inject the electrospinning mother liquor into the electrospinning machine, press the voltage of 10kv, the solution flow rate is 0.04mm / min, the receiving distance is 10cm, and the rotating speed is 15r / min. The electrospinning was carried out under the spinning condition of min, and the PCL-PVP composite micro-nano fiber membrane loaded with curcumin was obtained;

[003...

Embodiment 2

[0033] (1) Preparation of curcumin-loaded PCL-PVP composite micro-nano fiber membrane by electrospinning: Mix dichloromethane and ethanol in a certain volume ratio to prepare an electrospinning mother liquor, in which the volume percentage of dichloromethane is 60% ; Then blend PCL and PVP at a mass ratio of 3:1, stir at room temperature until transparent, prepare a mixed solution with a mass concentration of 8%, and then add a concentration of 12 mg / ml to the above-mentioned PCL-PVP mixed solution Curcumin, stir rapidly at room temperature until completely dissolved to obtain the electrospinning mother liquor, inject the electrospinning mother liquor into the electrospinning machine, press the voltage of 15kv, the solution flow rate is 0.1mm / min, the receiving distance is 15cm, and the rotating speed is 20r / min. The spinning parameters of min were electrospun to obtain the PCL-PVP composite micro-nano fiber membrane loaded with curcumin;

[0034] (2) Ultrasonic treatment of c...

Embodiment 3

[0037] (1) Preparation of curcumin-loaded PCL-PVP composite micro-nanofiber membrane by electrospinning: Mix dichloromethane and ethanol in different volume ratios to prepare an electrospinning mother liquor, in which the volume percentage of dichloromethane is 70% ; Then blend PCL and PVP at a mass ratio of 1:1, stir at room temperature until transparent, and prepare a mixed solution with a mass concentration of 12%, and then add a concentration of 20 mg / ml to the above-mentioned PCL-PVP mixed solution. Curcumin, stir rapidly at room temperature until completely dissolved to obtain the electrospinning mother liquor, inject the electrospinning mother liquor into the electrospinning machine, press the voltage of 20kv, the solution flow rate is 0.2mm / min, the receiving distance is 20cm, and the rotating speed is 30r / min. The spinning parameters of min were electrospun to obtain the PCL-PVP composite micro-nano fiber membrane loaded with curcumin;

[0038] (2) Ultrasonic treatmen...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Tensile strengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses a curcumin-loaded collagen-PCL-PVP composite micro-nano fiber membrane and a preparation method thereof. The preparation method is characterized by comprising the steps that firstly, dichloromethane and ethyl alcohol which have the certain volume ratio are mixed to be prepared into an electrostatic spinning solvent; secondly, curcumin, PCL and PVP which have the certain mass proportion are mixed to be added into the electrostatic spinning solvent and stirred at room temperature until the mixture is transparent, spinning mother liquid with the concentration of 6%-12% is prepared, the spinning mother liquid is injected into electrostatic spinning equipment to be spun, and then a curcumin-loaded PCL-PVP composite micro-nano fiber membrane is obtained; thirdly, the composite membrane is placed in an ultrasonic generator to be subjected to intermittent ultrasonic treatment; lastly, the composite membrane is steeped into an I type collagen solution and naturally aired, and then the curcumin-loaded collagen-PCL-PVP composite micro-nano fiber membrane is prepared. The material has the good biocompatibility and biodegradability, can promote cell growth, proliferation and adhesion, has the effects of resisting inflammations and oxidization, promoting wound healing and the like and can be used as a tissue engineering scaffold, high-grade dressings, a hemostatic material and the like.

Description

technical field [0001] The invention relates to a curcumin-loaded collagen-PCL-PVP composite micro-nano fiber membrane and a preparation method thereof, belonging to the field of biomedical material preparation. Background technique [0002] Due to the advantages of large specific surface area, high porosity and good physical and mechanical properties, the micro-nanofiber membrane material prepared by electrospinning technology has been widely used in drug slow / controlled release, filter paper, semi-permeable membrane, biosensor, energy source, etc. Storage, cell carrier, environmental engineering, tissue engineering scaffold and other fields. Polycaprolactone (PCL) is a semi-crystalline polymer with excellent biodegradability. At present, the US FDA has approved PCL as a material for surgical sutures, controlled drug release, fracture fixation, and tissue engineering scaffold materials. Substrate. However, studies have shown that PCL has disadvantages such as slow degrada...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): D06M10/02D06M15/15D01F1/10D01D5/00D04H1/4382D06B13/00A61L15/24A61L15/26A61L15/32A61L15/44A61L24/00A61L27/48A61L27/54A61L27/58D06M101/32D06M101/18
CPCA61L15/24A61L15/26A61L15/325A61L15/44A61L24/0015A61L24/0042A61L24/0094A61L27/48A61L27/54A61L27/58A61L2300/216A61L2300/404A61L2300/41A61L2300/412D01D5/0061D01D5/0092D01F1/103D04H1/4382D06B13/00D06M10/02D06M15/15D06M2101/18D06M2101/32C08L67/04C08L39/06
Inventor 但卫华刘新华但年华
Owner SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap