Preparation method of anti-coagulation hemodialysis membrane

A technology of hemodialysis and anticoagulation, which is applied in the field of preparation of anticoagulant hemodialysis membranes, can solve problems such as unsatisfactory anticoagulant performance, achieve improved hydrophilicity and anticoagulant performance, improve hydrophilicity, The effect of improving anticoagulant ability

Active Publication Date: 2017-03-01
江苏朗生生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, commonly used synthetic dialysis membranes such as polysulfone (PSF), polymethylmethacrylate (PMMA), polyethersulfone (PES), polyamide (PA) and polyacrylonitrile (PAN) have large pore High permeability and ultrafiltration rate, hi

Method used

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  • Preparation method of anti-coagulation hemodialysis membrane
  • Preparation method of anti-coagulation hemodialysis membrane
  • Preparation method of anti-coagulation hemodialysis membrane

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Embodiment Construction

[0020] The preparation method of the anticoagulant hemodialysis membrane of the present invention is carried out according to the following steps:

[0021] (1) Preparation of acrylonitrile-ethyl methacrylate copolymer.

[0022] Add acrylonitrile and ethyl methacrylate into the reactor at a mass ratio of 0.1 to 5.5:1. Acrylonitrile and ethyl methacrylate at a mass ratio of 1.5 to 4.5:1. Use nitrogen bubbling to remove oxygen. Blow in nitrogen gas for 30 minutes to remove the dissolved oxygen. While stirring, the polymerization initiator is added dropwise to initiate radical polymerization. The mass ratio of the polymerization initiator of the present invention to acrylonitrile and ethyl methacrylate is 0.001 to 0.1:1. The mass ratio can be controlled at 0.002~0.06:1, the dropping time is controlled at 10~20min, the temperature is raised to 40~100℃ for polymerization reaction, the reaction time is controlled at 1~20h, and the reaction can be carried out under nitrogen protection. Th...

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Abstract

The invention relates to a preparation method of an anti-coagulation hemodialysis membrane. The preparation method includes the steps of: a) adding acrylonitrile and ethyl methacrylate into a reaction kettle according to mass ratio of 0.1-5.5:1, stirring the mixture and dropwise adding a polymerization initiator to initiate free radical polymerization to obtain an acrylonitrile-ethyl methacrylate copolymer; b) blending 1-5.5% of the acrylonitrile-ethyl methacrylate copolymer, 12-18% of polysulfone, 1-12% of an additive, and 65-85% of a solvent to prepare a membrane solution, and spinning the membrane solution to manufacture hollow-fiber hemodialysis membrane; and c) dissolving an active monomer containing an alkene double bond and a hydrophilic group in deionized water, and adding a cerium ammonium nitrate grafting initiator to prepare a soaking water solution, and soaking the hollow-fiber hemodialysis membrane in the soaking water solution to initiate a grafting reaction of the active monomer on the surface of the hollow-fiber hemodialysis membrane, and cleaning the hollow-fiber hemodialysis membrane. The surface hydrophilicity of the hemodialysis membrane is significantly improved. The hemodialysis membrane has high biocompatibility and anti-coagulation performance.

Description

Technical field [0001] The invention relates to a method for preparing an anticoagulant hemodialysis membrane, and belongs to the technical field of hollow fiber hemodialysis membranes. Background technique [0002] Hemodialysis is an effective alternative therapy for the treatment of acute and chronic renal failure. The clinical application of hemodialysis equipment consists of a dialysis machine, a water treatment system, a dialysate system and a dialyzer. It can replace the human kidney to achieve the purpose of blood purification. The process of hemodialysis is to selectively permeate the membrane as the separation medium and use the concentration gradient, osmotic pressure gradient and pressure gradient between the blood on both sides of the membrane and the dialysate to make the blood urea, myosinic acid and uric acid in patients with acute and chronic renal failure. Wait for toxins and excessive water retained in the body to diffuse to the dialysate. At the same time, re...

Claims

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Application Information

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IPC IPC(8): B01D71/68B01D69/08B01D67/00A61M1/18
Inventor 戈旭亚于海军
Owner 江苏朗生生命科技有限公司
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