Check patentability & draft patents in minutes with Patsnap Eureka AI!

Novel polymer micro-needle array and preparation method thereof

A technology of microneedle array and polymer, which is applied in the direction of microneedles, non-active components of polymer compounds, needles, etc., can solve the problems of complex process and small holes in the mold, and achieve simple operation process, easy demoulding, Good results in formability and mechanical properties

Inactive Publication Date: 2017-05-10
南通普莱德医疗器械科技有限公司
View PDF7 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent adopts injection molding method to produce hyaluronic acid microneedles, and there are defects: due to the high viscosity of hyaluronic acid solution, the cavity of the mold is small, and it is difficult to inject the solution into the cavity of the mold
This preparation method is complex

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel polymer micro-needle array and preparation method thereof
  • Novel polymer micro-needle array and preparation method thereof
  • Novel polymer micro-needle array and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0042] A method for preparing a novel polymer microneedle array, through the steps of preparing a raw material solution, pouring the original solution, heating and curing, and demolding, to complete the preparation of a novel polymer microneedle array; the specific steps are as follows:

[0043] (1) Prepare the raw material solution: Weigh the raw material according to the mass ratio, take a certain amount of deionized water to prepare it into a uniform transparent solution, and let it stand at room temperature to remove the bubbles in the solution;

[0044] (2) Pouring of the original solution: pour the bubble-removed solution in step (1) into the PDMS mold in sequence;

[0045] (3) Heating and curing: heat the mold in step (2) at a vacuum degree of -100MPa-50MPa and a temperature of 16-90°C for 0.1-26 hours to cure and form;

[0046] (4) Demolding: The cured microneedle array is demolded at room temperature, and the preparation of the new polymer microneedle array is complet...

Embodiment 1

[0048] Under room temperature condition, be divided into the collagen of 10 grams by weight and 90 grams of chitosan lactate by weight and be dissolved in the deionized water that is divided into 100 grams by weight, stirring and dissolving, to fully dissolving, the mixed solution obtained , stand still to remove air bubbles, inject the solution that removes air bubbles into a 3*30 PDMS mold, put the mold containing the solution into a vacuum drying oven, and when the vacuum degree is 0.1Mpa, the temperature of the vacuum drying oven is 50°C, and then solidify and form. , after 18 hours, take out the cured microneedle array from the drying oven. In a natural environment at room temperature, the microneedles are manually removed from the PDMS mold to obtain a biocompatible microneedle array that can penetrate the skin.

Embodiment 2

[0050] Such as figure 1 As shown, at room temperature, poloxamer with a weight of 50 grams and sodium hyaluronate with a molecular weight of 50 grams of 1.13 million are dissolved in deionized water with a weight of 98 grams. Poloxamer and hyaluronic acid The mixed solution of sodium was poured into a conical PDMS mold with a height of 0.6mm and a diameter of 0.4mm. Under the vacuum degree of 0.1Mpa, it was cured for 20 hours at a temperature of 60°C in a drying oven. The formed mold , take out the mold directly, and obtain a microneedle array with good shape and high mechanical strength, and the height of the microneedle is 600μm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a novel polymer micro-needle array and a preparation method thereof. The novel polymer micro-needle array comprises a mixture of two or more than two of hyaluronic acid, collagen, chitosan lactate, polyvinylpyrrolidone, poloxamer, polyethylene glycol-polyvinyl alcohol copolymer, and chondroitin sulfate. The preparation method comprises the following steps of preparing a raw material solution, casting the raw material solution, heating and curing, and demolding, so as to prepare the novel polymer micro-needle array. The novel polymer micro-needle array has the advantages that a prepared biocompatible or biodegradable material defoamed solution is injected into a PDMS (polydimethylsiloxane) mold, and the micro-needle array has enough mechanical strength; the demolding of the prepared micro-needle array is easy, the forming and mechanical properties are good, and the array can be punctured into skin; by adding the chondroitin sulfate into the formula, the mechanical strength of the micro-needle array is effectively improved, and the array can be conveniently punctured into the skin; by using the micro-needle array as a carrier, the effective ingredients of cosmetics are punctured into the skin, and dissolved into the skin, so that the effective ingredients of the cosmetics are favorably absorbed.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical microneedle preparation, in particular to the preparation of a novel polymer microneedle array. Background technique [0002] At present, most drugs are administered orally in the form of tablets and capsules. However, due to the absorption of drugs in the gastrointestinal tract and the first-pass effect in the liver, many oral drugs reduce the bioavailability of the drug before reaching the site of action; Some drugs cannot be taken orally, such as: peptides and protein-related drugs. [0003] Another common mode of administration is injection, which enables drugs to penetrate biological barriers, including subcutaneous injection and intravenous infusion. Although this method is fast and effective, the injection can cause additional pain for the patient, causing skin damage and bleeding at the injection site, and sometimes causing skin inflammation and other symptoms. At the same time, t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/00A61K47/42A61K47/36A61K47/32A61K47/10A61M37/00
CPCA61M37/0015A61K9/0021A61M2037/0053A61K47/10A61K47/32A61K47/36A61K47/42
Inventor 胡隆胜张冉张苗
Owner 南通普莱德医疗器械科技有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com