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Manufacturing method for manufacturing magnesium alloy vascular stent

A technology for magnesium alloy blood vessels and blood vessel stents, which is applied in the field of processing and preparation of high-purity magnesium alloy absorbable blood vessel stents, can solve the problems of high cost and complicated process, and achieve the effects of reducing manufacturing costs, simplifying processes, and inhibiting stent endothelialization.

Active Publication Date: 2017-05-10
杨水祥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The purpose of the present invention is to solve the problems of low yield strength, poor plasticity, and vascular sclerosis caused by easily damaged cells in the existing absorbable vascular stents, and to provide a 3D printing technology to prepare high-purity magnesium alloy absorbable vascular stents and Its preparation method solves the technical problems of complicated process and high cost existing in the production of existing magnesium alloy stents

Method used

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  • Manufacturing method for manufacturing magnesium alloy vascular stent
  • Manufacturing method for manufacturing magnesium alloy vascular stent
  • Manufacturing method for manufacturing magnesium alloy vascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: prepare high-purity magnesium alloy stent

[0042] Such as image 3 As shown, magnetron sputtering equipment (magnetron sputtering deposition system B13-054, machine power 15KW, sputtering power 30W) is used for magnetron sputtering, and magnetron sputtering is carried out in a vacuum chamber 201. Specifically, the prefabricated The body is placed on the anode rotating frame 205 in the vacuum chamber, the magnesium alloy target 202 is secured on the cathode 203 of the vacuum chamber, and then the vacuum chamber 201 is closed. Run mechanical pump 208 to evacuate to 20Pa. Then use the molecular pump 207 to make the vacuum degree of the vacuum chamber reach 5*104Pa. Pass pure argon gas into the vacuum chamber 201 from the gas inlet 206 to make the air pressure in the vacuum chamber 0.8 Pa, and control the rotational speed of the anode rotating frame to 150 r / min.

[0043] Turn on the sputtering power supply, the sputtering power is 20W, so that the magnesi...

Embodiment 2

[0046] Embodiment 2: animal experiment research

[0047] The research subjects were 50 hybrid test dogs that had been vaccinated against the epidemic. They were randomly divided into 5 groups, with 10 dogs in each group. Each test dog was implanted with an absorbable stent in the femoral artery, and placed 3-5 cm away from the place where the stent was placed. Balloon dilation was performed. 24 hours, three days, five days, one week to six weeks, eight weeks, and three months after the operation, the materials were collected for pathological analysis and tissue biochemical research to clarify the physical and chemical properties, biocompatibility and absorbability of the scaffold. Sex, absorbable time, safety and effectiveness of the stent, and establish a data database. attached image 3 It is the pathological analysis results of the experimental dogs at 1 day, 3 days, 5 days, 1 week, 2 weeks, 3 weeks, 26 days and 4 weeks after operation. The experimental results show that...

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Abstract

The invention provides a manufacturing method for manufacturing a magnesium alloy vascular stent, and the manufacturing method adopts a 3D (three dimensional) printing technology to solve the technical problems that an existing magnesium alloy stent is complex in process and high in cost during manufacturing. The manufacturing method comprises the following steps: adopting the 3D printing technology to manufacture a prefab of the magnesium alloy vascular stent; adopting magnetron sputtering for sputtering a magnesium alloy target to the surface of the prefab; soaking the prefab sputtered with the magnesium alloy target into an alcohol solution or an aqueous solution to dissolve the prefab, thereby obtaining the magnesium alloy vascular stent. The manufacturing method adopted by the invention simplifies the process, reduces the cost and has a wide application prospect. And a novel tunicamycin drug coating is adopted, so that formation of postoperative restenosis is reduced, and the curative effect and safety are improved.

Description

technical field [0001] The invention relates to a metal stent used in the field of vascular interventional therapy and a processing method thereof, in particular to a processing and preparation method of a high-purity magnesium alloy absorbable vascular stent. Background technique [0002] The incidence of cardiovascular and cerebrovascular diseases is getting higher and higher, and it has become one of the three major diseases that endanger human life, health and safety. Vascular stenosis is a high-incidence disease that causes serious consequences such as heart failure and stroke. For the treatment of cardiovascular and cerebrovascular stenosis, the existing treatment methods mainly include medicine, operation and stent formation. Among them, drugs can reduce the relative risk of ischemic stroke by 13%, but the therapeutic effect is not obvious. The complication rate of surgery is high, and there is a certain risk. Interventional therapy has become the most effective wa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/34A61L27/54A61L27/58C23C14/35C23C14/20
CPCA61L27/047A61L27/34A61L27/54A61L27/58A61L2300/232A61L2300/416A61L2300/606C23C14/0005C23C14/205C23C14/35C08L67/04
Inventor 杨水祥
Owner 杨水祥
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