Fibroin three-dimensional bracket for nervus centralis remediation

Abstract

The invention relates to a fibroin three-dimensional bracket for nervus centralis remediation, and belongs to the field of biological medicinal materials. The fibroin three-dimensional bracket comprises fibroin protein fiber with grooves, fibroin protein / hyaluronic acid plural gel and fibroin membrane conduits. By adopting the fibroin three-dimensional bracket, defects that a conventional bracket is low in mechanical property, low in biodegradability and the like are overcome. By adopting the fibroin three-dimensional bracket, physiological states of an extracellular matrix can be simulated, adhesion, migration, amplification and differentiation of cells can be facilitated, and furthermore orientated growth of axon to fracture parts can be guided; due to connection of the bracket, glial scars can be inhibited, and thus remediation of a nervus centralis system can be facilitated; and the bracket can be applied to basic research on neural injury remediation, can be also applied to bridging remediation of human body spinal cord injury or deficiency, and has good biomedical prospects.

Description

technical field [0001] The invention relates to a three-dimensional silk fibroin bracket which can be used for central nervous system repair, is mainly used for repairing spinal cord defects in the central nervous system, and belongs to the field of biomedical materials. Background technique [0002] Spinal cord injury is a serious injury to the central nervous system, and its repair is still one of the clinical problems. This is mainly because the self-repair ability is limited after spinal cord injury, and the damaged nerve cells are difficult to regenerate. At the same time, myelin-related inhibitory factors in the body will inhibit the regeneration of axons, which is closely related to functional recovery, and finally lead to the formation of scar barriers. [0003] With the continuous progress and wide application of new technology and technology, the research on the repair of spinal cord injury has made some progress, but it still cannot meet the requirements of clinic...

AI Technical Summary

Problems solved by technology

[0006] Prior to this, people used chitosan as a scaffold for repairing the spinal cord. Although the scaffold is easy to prepare, has controllable mechanical and degradation properties, and is conducive to the adhesion of related molecules and cell growth, it has the disadvantages of poor strength and incompatibility with seed cells.

People also try to use collagen, fibrin gel, alginate gel, polylactic acid, polycaprolactone, etc. as tissue engineering scaffolds, but there are some problems in biocompatibility and mechanical properties