New application of rifamycin-nitroimidazole coupling molecule

A technology of nitroimidazolium and rifamycin, which is applied in the field of medicinal chemistry and can solve the problem of no documented antibacterial activity of anaerobic flora
CN106860451AInactive Publication Date: 2017-06-20TENNOR THERAPEUTICS (SUZHOU) LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TENNOR THERAPEUTICS (SUZHOU) LTD
Publication Date
2017-06-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an application of a rifamycin-nitroimidazole coupling molecule shown in formula I in restraining anaerobic flora. The rifamycin-nitroimidazole coupling molecule shown in formula I provided by the invention has a broad-spectrum antibacterial activity to anaerobion, has an activity to most pathogenic bacteria related to bacterial vaginosis, has a better in vitro antimicrobial activity than that of bacterial vaginosis drugs, such as, metronidazole and clindamycin, and has an excellent application prospect at the aspect of preventing and treating the bacterial vaginosis or the other related diseases caused by the anaerobion.
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Description

technical field

[0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a new application of a rifamycin-nitroimidazole coupling molecule. Background technique

[0002] Anaerobic bacteria are a group of bacteria that grow better in the absence of oxygen than in aerobic environments, but cannot grow on the surface of solid media at air (18% oxygen) and / or 10% carbon dioxide concentrations . This type of bacteria lacks a complete metabolic enzyme system, and its energy metabolism is carried out by anaerobic fermentation.

[0003] Anaerobic bacteria include the following categories:

[0004] 1. Gram-positive anaerobic cocci (GPAC)

[0005] Including Peptostreptococcus, Finegoldia, Anaerococcus, Peptoniphilus, Veillonella, etc., are the human oral cavity, upper respiratory tract, gastrointestinal tract and Part of the microbial flora of the female genitourinary system, it is an opportunistic pathogen that can cause various degrees of in...

Claims

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