High-porosity dry powder inhaler carrier and supersaturated synthesis method and applications thereof

Abstract

The invention relates to a high-porosity dry powder inhaler carrier and its supersaturated synthesis method and application. The carrier is a flower-shaped porous dry powder particle with a rough surface, and the median diameter of a single particle under the electron microscope display is 0.5-50 microns. The loading capacity of drug molecules is 5-50% by mass, the N2 adsorption specific surface area of ​​the carrier is 10-100 square meters per gram, and contains micro, medium and macropores. The present invention combines supersaturated synthesis technology and flower-shaped material preparation technology for the first time, and applies it to the field of dry powder inhalers. The high-porosity dry powder inhaler carrier prepared by adopting the synthesis method provided by the present invention has controllable size and high The porosity nanopore system is applied to the adsorption, loading and transportation of nanoscale and molecular components, with good uniformity, stability and transmission efficiency. The invention realizes high-efficiency, high-quality, low-cost and practical mass production of nano- and micron-level high-porosity dry powder inhaler carrier materials.

Description

technical field [0001] The invention relates to the technical field of drug carriers, in particular to a high-porosity dry powder inhaler carrier and its supersaturated synthesis method and application. Background technique [0002] Dry powder inhaler is a commonly used spray for lung medication. It is composed of drug molecules and carrier particles, in which the drug molecules act on the lungs, and the carrier material is used to carry the drug molecules to achieve the effect of drug delivery. The carrier used as a dry powder inhaler has strict health requirements and must be a material that can be absorbed by the respiratory tract and lung cells or has no effect, such as sugars and sugar alcohols; considering the size of the lung terminal channel, direct drugs or carriers The shape of the material is preferably particles with a size of 1-5 microns. At the same time, based on the structure of the respiratory tract of the lungs, the carrier material for the front-end delive...

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Problems solved by technology

Due to the improvement of spray drying parameters, the mixing degree of each drug component has been improved, and the product particles can reach a smaller particle size after spray drying treatment, which meets the standard requirements; but because spray drying granulation has higher requirements for solute solubility Large, the drug product cannot be fully dissolved in water, resulting in crystallization of the product and uneven distribution of the drug, and poor absorption. At the same time, the particle size range of the spray-dried granulation is wide, usually 1-20 microns (with a median particle size of 10 microns For example), the size uniformity is not high, which affects the drug delivery efficiency of pulmonary medication

[0005] In order to improve the porosity of the carrier particle material for adsorbing drug particles, a flower-shaped particle material has been described in the prior art, which is published in the 7th issue of "Nature Nanotechnology" in 2012 by Jun Ge et al. "inorganic hybrid nanoflowers" protein material, indicating that the porous flower-shaped granular material can greatly improve the loading capacity, efficiency and shelf life of the drug when used as a drug carrier; but the protein carrier material cannot be used as a drug carrier for the lungs. The carrier material also cannot use this method to synthesize flower-shaped granular materials similar to this form

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