Cell lipid droplet specific-labeling fluorescent probe

A fluorescent probe and a specific technology, applied in the lipid droplet fluorescent probe and its application field, can solve the problems of hindering further research on lipid droplets, unable to meet research needs, and difficult to achieve highly selective imaging of lipid droplets, and achieve rapid Dyeing ability, fast dyeing speed, good light stability effect
CN106946869AInactive Publication Date: 2017-07-14SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2017-07-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a cell lipid droplet specific-labeling fluorescent probe. The fluorescent probe has a chemical name of 1-(3'-(7'-nitrobenzofuran-4'-)aminopropyl)-4-methylpyridine bromide and has a general chemical formula shown in the formula (I). The invention also discloses a use of the fluorescent probe in specific labeling or display of a lipid droplet form and distribution in living cells. An experiment result shows that the cell lipid droplet specific-labeling fluorescent probe has the characteristics of very high selectivity, background noise-free imaging, two-photon performances, very good light stability, fast dyeing ability, no use of washing and low cytotoxicity and has a great application prospect.
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Description

technical field

[0001] The invention relates to a lipid drop fluorescent probe and its application, in particular to a fluorescent probe for specifically marking lipid droplets in cells and its application. Background technique

[0002] Lipid droplets have long been recognized as simple, inert spheres that store neutral lipids (triglycerides and cholesteryl esters) in cells. However, recent studies have shown that lipid droplets are not static, but highly dynamic organelles in cells, widely present in eukaryotic and prokaryotic cells. They play important roles in cells and participate in various activities in cells, such as regulating the metabolism of intracellular lipids, maintaining intracellular balance, and interacting with various organelles in cells. Moreover, the abnormality of lipid droplets can lead to many diseases, such as obesity, diabetes, atherosclerosis and so on.

[0003] Lipid droplets have a large anhydrous neutral core, so some lipophilic probes have be...

Claims

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