Premixed calcium silicate based root canal filling material with suspension stability as well as preparation method and application thereof

A technology of suspension stability and filling materials, applied in dental preparations, pharmaceutical formulations, medical science, etc., can solve the problems of ineffective regulation of dental pulp cell differentiation and induction of dentin bridges, easy degradation and loss of organic dispersants, and no chemical bonding, etc. problem, to achieve the effect of shortening the setting time, excellent edge sealing, and good biological activity

Active Publication Date: 2017-08-22
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the organic dispersant is easily degraded and lost in the body, causing micro-porosity in the curing system, which in turn leads to the occurrence of root canal micro-leakage
The disadvantage is that calcium phosphate bone cement does not have the ability to mineralize and form chemical bonds with dentin in body fluids, and cannot effectively regulate the differentiation of dental pulp cells and induce the formation of dentin bridges. Less than MTA material

Method used

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  • Premixed calcium silicate based root canal filling material with suspension stability as well as preparation method and application thereof
  • Premixed calcium silicate based root canal filling material with suspension stability as well as preparation method and application thereof
  • Premixed calcium silicate based root canal filling material with suspension stability as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1, preparation of premixed suspension stable calcium sulfate hemihydrate / calcium silicate compound paste

[0040] 1. Raw material preparation:

[0041] Calcium sulfate hemihydrate is prepared by drying and dehydrating calcium sulfate dihydrate, that is, after grinding calcium sulfate dihydrate, heat it in an oven at 150°C for 12 hours, then adjust the temperature of the oven to 60°C, and age for 6 hours. 300 mesh sieve.

[0042] The calcium silicate compound is a mixture of tricalcium silicate and dicalcium silicate.

[0043] Glycerin is selected as the water-miscible non-aqueous solvent.

[0044] Zirconia powder is selected as the anti-radiation material.

[0045] The suspension stabilizer is fumed silica.

[0046] 2. Compound paste preparation:

[0047] Weigh 0.3g calcium sulfate hemihydrate, 0.56g tricalcium silicate, 0.14g dicalcium silicate, 0.96g zirconia, 0.04g fumed silica, 1mL glycerin, put them into a glass container, and use a stainless steel ...

Embodiment 2

[0049] Embodiment 2, preparation of premixed suspension-stabilized magnesium phosphate / calcium silicate compound paste

[0050] 1. Raw material preparation:

[0051] Magnesium phosphate bone cement powder, including dead burnt magnesia, sodium dihydrogen phosphate. Dead-burned magnesia is obtained by calcining light magnesia at 1500°C for 2 hours, and sodium dihydrogen phosphate is directly used as a purchased reagent. Dead burnt magnesium oxide and sodium dihydrogen phosphate were ball milled for 12 hours respectively, and passed through a 400 sieve. Dead burnt magnesium oxide and sodium dihydrogen phosphate according to the molar ratio of 3.8:1, ball milling and mixing for 12 hours to prepare magnesium phosphate powder.

[0052] As the calcium silicate compound, wind crushed grade tricalcium silicate is selected.

[0053] The water-miscible non-aqueous solvent is 1,2-propanediol.

[0054] Bismuth oxide powder is selected as the anti-radiation material.

[0055] Suspension...

Embodiment 3

[0059] Embodiment 3, the curing time of composite paste

[0060] 1. Paste preparation:

[0061] Experimental group: the composite paste prepared in Example 1 and Example 2.

[0062] Control group 1: Weigh 0.8g tricalcium silicate, 0.2g dicalcium silicate, 0.96g zirconia, 0.04g fumed silica, 1mL glycerin, put them into a glass container, and fully reconcile them with a stainless steel stirring rod for 5 minutes to obtain Premixed calcium silicate based compound paste.

[0063] Control group 2: Weigh 1g tricalcium silicate, 0.95g bismuth oxide, 0.05g organobentonite, 0.8mL 1,2-propylene glycol, and mix them in a planetary ball mill for 10 minutes to obtain a premixed tricalcium silicate composite paste .

[0064] 2. Curing time test:

[0065] The test method selects the test method specified in the industry standard YY0717-2009. Fill the paste prepared above into a hydrated plaster mold, put it into a constant temperature and humidity chamber with a temperature of 37°C and ...

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Abstract

The invention provides a premixed calcium silicate based root canal filling material with suspension stability as well as a preparation method and an application thereof. At least one calcium silicate compound is used as a main phase, and at least a second phase for improving solidification performance, at least one nonaqueous phase solvent which can be mixed with water, at least one suspension stabilizing agent and at least one radiopaque material are added in order to prepare the root canal filling material with excellent injectable performance. An inorganic dispersant with suspension stabilizing effect is added into the premixed type calcium silicate based root canal filling material system, based on reservation of excellent biological compatibility, biological activity, marginal sealability, and the like of the calcium silicate material, layering, deposition or flocculation of the premixed system are effectively prevented, long-term dispersion stability of the premixed paste is improved, and the material can be used as a filling material for dental pulp capping, root canal therapy, and other dental restoration fields.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a suspension-stable premixed calcium silicate-based root canal filling material and a preparation method and application thereof. Background technique [0002] Mineral trioxide aggregate (MTA) is a new type of calcium silicate-based root canal filling treatment material. Since it was first reported by Lee in 1993, it has attracted extensive attention from researchers and clinicians, and it was approved by the US FDA in 1998. Licensed for clinical use. MTA material is composed of a variety of inorganic particles, the main components include tricalcium silicate, dicalcium silicate and other inorganic mineral particles. The main features of MTA used as root canal filling material are excellent marginal sealing, excellent biocompatibility, bioactivity and antibacterial properties. In addition, MTA curing is not affected by moisture and blood. It has high compressive ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/027A61K6/033A61K6/02A61K6/00A61K6/838
CPCA61K6/54A61K6/70A61K6/80A61K6/831A61K6/838
Inventor 窦源东陈振华孙先昌郇志广常江
Owner YANTAI ZHENGHAI BIO TECH
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