Ultrasonic contrast agent with ultra-long duration and preparation method thereof

Abstract

The invention relates to the field of medicines, and particularly discloses an ultrasonic contrast agent with ultra-long duration time and a preparation method of the ultrasonic contrast agent. The contrast agent has the advantage that the contrast duration time for the organs such as the liver, the kidney and the spleen reaches 2 hours or a longer time, the longest duration time can reach 6 hours or a longer time, and the ultrasonic contrast agent belongs to the contrast agent with the longest ultrasonic contrast duration time in the micro-bubble type ultrasonic contrast agents reported at present. In addition, the preparation process of the contrast agent is simple and controllable, the large-scale production can be easily realized, the production raw materials are injectable medicinal auxiliary materials which are approved at present, and thus the clinical application prospect is broad.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an ultra-long duration ultrasonic contrast agent and a preparation method thereof. Background technique [0002] Ultrasound contrast agents are usually lipid, polymer, or protein-encapsulated gas microbubbles with a diameter of less than 10 microns, which can be used to enhance the echo signal of the detection site in ultrasound imaging. Ultrasound contrast agents have great advantages in the detection and imaging of human microvascular and tissue blood perfusion. In addition, studies in recent years have shown that ultrasound contrast agents have broad application prospects in targeted imaging and drug delivery of tumors or inflammatory sites. or an indispensable reagent in therapy. [0003] At present, many products of ultrasound contrast agents have entered clinical application, such as Definity, Optison, Sonazoid, Sonovue, etc. in the international market, and Sonovue and Xueruixin ...

AI Technical Summary

Problems solved by technology

Although ultrasound contrast agents have many application advantages in ultrasound diagnosis, at present, ultrasound contrast agents are rarely used by ordinary people in domestic clinical diagnosis, and generally only in hospitals above the top three.

One of the important reasons for this is that the price of contrast agents is very expensive. For example, the price of a bottle of Sonovue is around 700 RMB, and the price of Xue Ruixin is as high as more than 900 RMB per bottle. The popularity of ultrasound contrast agents

In addition, the imaging time of the existing ultrasound contrast agents is relatively short (the effective time of Sonovue is 4-8 minutes, and Xueruixin is less than 2 minutes), which is difficult to meet the needs of a complete ultrasound examination

For example, studies have found that Definity has a better ultrasonic thrombolytic effect because it contains a certain proportion of nanobubbles, while albumin microbubbles under the same conditions have no such effect because they are all micron-sized.

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