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A kind of three-dimensional printing porous wollastonite bioceramic scaffold and its preparation method and application

A technology of bioceramics and wonotlite, which is applied in the field of biomedical materials, can solve the problems of insufficient mechanical properties, limited application, poor connectivity of porous bone repair scaffold materials, etc., and achieve compact microstructure, promote bone tissue ingrowth, Enhanced bone regeneration effect

Active Publication Date: 2019-12-13
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor bone repair scaffold materials traditionally prepared by pore-forming agent method, foaming method and freeze-drying method have problems such as poor pore connectivity and insufficient mechanical properties, which limit their application in bone defect repair.

Method used

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  • A kind of three-dimensional printing porous wollastonite bioceramic scaffold and its preparation method and application
  • A kind of three-dimensional printing porous wollastonite bioceramic scaffold and its preparation method and application
  • A kind of three-dimensional printing porous wollastonite bioceramic scaffold and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, the preparation of three-dimensional printing wollastonite bioceramic support

[0036] 1. Raw material preparation:

[0037] (1) Synthesis of white wollastonite powder

[0038] The white wollastonite (Ca 7 MgSi 4 o 16 ) powder.

[0039] Take 112mL tetraethyl orthosilicate and 72mL water and 40mL of 2mol L -1 Nitric acid (take 69.4mL of commercially available 65-68% concentrated nitric acid and appropriate amount of water, stir and mix, and then dilute to 500mL to obtain 2mol·L-1 nitric acid), mix, stir and hydrolyze for 0.5h. Add 206.6g calcium nitrate tetrahydrate and 64.1g magnesium nitrate successively, and stir for 5h. Sealed and aged at 60°C for 24h, then dried at 120°C for 48h to obtain a xerogel. After the xerogel is ball milled, it is calcined at 1150° C. for 3 hours, and after natural cooling, it is ball milled and passed through a 200-mesh sieve to obtain the white wollastonite powder.

[0040] (2) Preparation of binder aqueous solution ...

Embodiment 2

[0050] Embodiment 2, preparation of three-dimensionally printed wollastonite bioceramic scaffold with fine structure

[0051] 1. Raw material preparation:

[0052] (1) Synthesis of wonotlite powder, the raw materials and method are the same as in Example 1.

[0053] (2) The preparation of aqueous binder solution, raw material and method are identical with embodiment 1.

[0054] (3) Preparation of sintering aids

[0055] The sintering aid chooses the purchased 45S5 bioactive glass powder.

[0056] (4) Preparation of 3D printing equipment

[0057] The 3D printer uses Nano-Plotter produced by German GeSiM company TM 2.1, the feeding air pressure is 2.0-3.0 atmospheres, the printing speed is 6.5mm / s, and the inner diameter of the printing needle is 0.41mm.

[0058] 2. Three-dimensional printing preparation of wonotlite bioceramic scaffolds:

[0059] (1) Weigh 4.3g of wonotlite powder, 0.7g of bioglass powder, and 2.8g of binder aqueous solution to fully reconcile and mix to...

Embodiment 3

[0063] Example 3, Preparation of Disc-shaped Three-dimensionally Printed White Notlite Bioceramic Scaffold

[0064] 1. Raw material preparation:

[0065] (1) Synthesis of wonotlite powder, the raw materials and method are the same as in Example 1.

[0066] (2) Preparation of binder aqueous solution

[0067] The binder is polyvinyl alcohol (polymerization degree: 1750±50). Weigh 6g of purchased polyvinyl alcohol into 100ml of boiling water, stir until dissolved, and obtain an aqueous binder solution.

[0068] (3) Preparation of sintering aids

[0069] The sintering aid chooses the purchased 45S5 bioactive glass powder.

[0070] (4) Preparation of 3D printing equipment

[0071] The 3D printer uses the Nano-Plotter TM 2.1 produced by GeSiM Company in Germany, the feeding air pressure is 2.5-3.5 atmospheres, the printing speed is 6.0mm / s, and the inner diameter of the printing needle is 0.41mm.

[0072] 2. Three-dimensional printing preparation of wonotlite bioceramic scaffo...

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Abstract

The invention discloses a three-dimensional printing porous bredigite biological ceramic bracket, and a preparation method and application thereof. The method comprises the following steps: firstly, obtaining a sizing agent by blending bredigite powder, sintering aids and a binder aqueous solution at a certain ratio, then utilizing a three-dimensional printing technique to prepare a ceramic bracket blank with a controllable porous structure, and then sintering at high temperature, thereby obtaining a bredigite biological ceramic bracket material with a porous structure and excellent mechanical properties. The three-dimensional printing porous bredigite biological ceramic bracket prepared according to the preparation method has controllable pore diameter and porosity, high biocompatibility, excellent mechanical properties obviously better than the mechanical properties of a calcium phosphate ceramic bracket with the same structure, and excellent induced osteogenesis activity and angiogenesis activity, and is expected to be used for boosting the regeneration repairing of various defected bone tissues.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a three-dimensionally printed porous white wollastonite bioceramic support and a preparation method and application thereof. Background technique [0002] Bone defects caused by trauma, tumors, congenital deformities, aging and accidents are the main threats to human health. Autologous bone transplantation, which is currently regarded as the clinical gold standard, is often limited by donor sources and secondary trauma. Allogeneic or heterogeneous bone repair materials have risks such as virus transmission and immune rejection. Therefore, artificial bone grafts with good bone regeneration properties Synthetic bone repair materials have urgent clinical needs and broad development prospects. [0003] The synthetic bone repair materials widely used in clinical practice are phosphate bioceramics, such as hydroxyapatite and β-tricalcium phosphate ceramics, which have t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/10A61L27/02A61L27/50A61L27/54C04B35/22C04B35/64C04B38/00B33Y10/00B33Y70/00B33Y80/00B28B1/00
CPCA61L27/025A61L27/10A61L27/50A61L27/54A61L27/56A61L2300/102A61L2300/412A61L2430/02B28B1/001B33Y10/00B33Y70/00B33Y80/00C04B35/22C04B35/64C04B38/0054C04B2235/36C04B38/0074C04B38/0003
Inventor 窦源东吴成铁孙先昌陈振华任志伟
Owner YANTAI ZHENGHAI BIO TECH
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