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Method for preparing composite micro-capsule with electrical stimulation response on surface of medical metal

A metal surface, electrical stimulation technology, used in medical science, electrolytic organic material coating, prosthesis, etc., can solve the problems of drug slow release system that cannot achieve dose, slow treatment effect, and inability to achieve, and is conducive to cell proliferation. and differentiation, promoting bone repair treatment, and increasing the effect of loading

Inactive Publication Date: 2017-11-03
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most drug release systems can only achieve stable release. Strictly speaking, it is a drug sustained release system rather than a drug controlled release system in the true sense. Drug sustained release systems generally cannot achieve dose changes, so real control cannot be achieved.
[0006] In addition, it should be pointed out that although drug treatment is an indispensable part of tissue repair, the side effects of drugs are also a problem worth worrying about.
For example, anticancer drugs can not only kill cancer cells, but also may cause damage to normal cells around the tumor, and drug resistance
Single physical therapy (such as electrotherapy) can avoid the influence of drug side effects, but its therapeutic effect is slower

Method used

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  • Method for preparing composite micro-capsule with electrical stimulation response on surface of medical metal
  • Method for preparing composite micro-capsule with electrical stimulation response on surface of medical metal
  • Method for preparing composite micro-capsule with electrical stimulation response on surface of medical metal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A method for preparing composite microcapsules with electrical stimulation response on the surface of medical metal, the specific steps are as follows:

[0038]A. After cleaning the medical titanium, drop polystyrene microsphere solution on its surface, and form a polystyrene microsphere template on the surface of the medical metal material after drying, and prepare the medical titanium prepared by the above method for later use;

[0039] B. Prepare dopamine monomer, pyrrole monomer, and dexamethasone to form an electrolyte: first mix dopamine monomer and dexamethasone, and then add pyrrole monomer after they have fully reacted. In the electrolyte, the dopamine monomer is 1 mmol / L, the pyrrole monomer is 0.1 mol / L, and the concentration of dexamethasone is 1 mmol / L.

[0040] C. Put the electrolyte in step B into the electrolytic cell of the three-electrode electrochemical system: the medical titanium with polystyrene microsphere template is the working electrode, the pl...

Embodiment 2

[0043] A method for preparing composite microcapsules with electrical stimulation response on the surface of medical metal, the specific steps are as follows:

[0044] A. After cleaning the medical titanium alloy, drop polystyrene microsphere solution on its surface, and form a polystyrene microsphere template on the surface of the medical metal material after drying, and prepare the medical titanium alloy prepared by the above method;

[0045] B. Prepare dopamine monomer, thiophene monomer, and chondroitin sulfate to form an electrolyte solution: first mix dopamine monomer and chondroitin sulfate, and then add thiophene monomer after they have fully reacted. In the electrolyte, the concentration of dopamine monomer is 20mmol / L, the concentration of thiophene is 0.5mol / L, and the concentration of dexamethasone is 10mmol / L.

[0046] C. Put the electrolyte in step B into the electrolytic cell of the three-electrode electrochemical system: the medical titanium alloy with polystyr...

Embodiment 4

[0055] The operation of this example is basically the same as that of Example 1, except that the conductive polymer monomer used in Example 1 is changed from pyrrole to aniline.

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Abstract

The invention discloses a method for preparing a composite micro-capsule with the electrical stimulation response on the surface of medical metal and belongs to the technical field of biology materials. According to the method, an electrolytic solution prepared from a dopamine monomer, a conductive macromolecule monomer and medicine negatively charged is connected into a three-electrode electrochemical system, a medical metal material with a microsphere template array serves as a working electrode, the electrolytic solution is deposited on the surface of the medical metal to obtain a microsphere template wrapped by dopamine, conductive macromolecules and medicine in a compositing manner, and finally, after microspheres are dissolved completely, the medical metal material with the surface wrapped with the composite micro-capsule is prepared. According to the method, the surface of the medical metal material is modified, the functionality conduction composite micro-capsule is prepared on the surface of the medical metal material, the composite micro-capsule can control medicine release through electrical signal control and regulate stem cell differentiation directly through electrical signals, medicine stimulation and physical stimulation collaborate, dependence on the medicine and the side effect of the medicine are reduced, and the bone induction ability of medical metal is also improved.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a method for preparing composite microcapsules with electric stimulation response on the surface of medical metal. Background technique [0002] Bone defects caused by a variety of reasons are very common in clinical practice, and large-area bone repair and weight-bearing bone repair are frequently faced problems in clinical treatment. Medical metal materials are the main load-bearing bone repair materials. It is a kind of metal or alloy used as biomaterials. Medical metal materials are a kind of biologically inert materials with high mechanical strength and fatigue resistance, and good biomechanical properties. However, the biological activity of medical metal materials is a performance index to be improved in its use. [0003] Human beings have entered an era of high demand for biological applications, and there is an urgent need to develop more active biomate...

Claims

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Application Information

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IPC IPC(8): C25D9/02A61L27/34A61L27/54A61L27/56
CPCA61L27/34A61L27/54A61L27/56C25D9/02
Inventor 鲁雄谢超鸣王振铭韩璐胥杰龙甘东林
Owner SOUTHWEST JIAOTONG UNIV
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