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Degradable shape memory endoluminal stent and preparation method thereof

A memory tube and inner stent technology, which is applied in the field of shape memory intraluminal stent and its preparation, can solve the problem that ES is not tightly combined with the lumen wall, etc., and achieve the effects of good biocompatibility and good shape memory.

Inactive Publication Date: 2017-11-14
HEILONGJIANG XINDA ENTERPRISE GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Lumen stenosis is a common clinical disease, and intraluminal stent implantation is currently one of the fastest and most effective methods for treating luminal stenosis. Leakage around the ES is a common complication, and the shape-memory alloys (SMAs) stents developed in recent years have effectively alleviated this problem. There are still certain limitations in its application due to the limitations of the vascular system, restenosis, and aneurysm formation or wall perforation caused by medial atrophy caused by long-term compression.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] L-lactide (LLA), glycolide (GL) refined by ethanol recrystallization method, ethylene glycol, stannous octoate as raw materials, L-lactide (LLA), glycolide (GL) The molar ratio is 1:6, the molar ratio of ethylene glycol to L-lactide (LLA) and glycolide (GL) is 1:20, and the catalyst stannous octoate (0.05wt%, based on LLA and GL total mass) at 140°C and N 2 Under protection, the pressure was reduced to 50 Pa, and the melt polymerization was carried out for 12 hours. After the reaction is over, add tetrahydrofuran to dissolve, then add methanol to precipitate and purify the product, and dry it in vacuum to obtain a white powdery hydroxyl-terminated PLGA for use; the above steps prepare hydroxyl-terminated PLGA with a number average molecular weight (Mn) of 2000. Polyester polybutylene succinate (PBS), hexamethylene diisocyanate (HDI) as raw materials, the molar ratio of PLGA, polybutylene succinate (PBS) is l:3, hexamethylene The molar ratio of HDI to PLGA and PBS is l...

Embodiment 2

[0026] D, L-lactide (DLLA), glycolide (GL), 1,3-propanediol and stannous chloride refined by ethanol recrystallization method are used as raw materials, D, L-lactide (DLLA), The molar ratio of glycolide (GL) is 1:1, the ratio of ethylene glycol to D,L-lactide (DLLA) and glycolide (GL) is 1:25, and the catalyst chlorinated Tin (0.1wt%, based on the total mass of DLLA and GL) at 160°C and N 2 Under protection, the pressure was reduced to 65 Pa, and the melt polymerization was carried out for 18 hours. After the reaction is over, add tetrahydrofuran to dissolve, then add methanol to precipitate and purify the product, and dry it in vacuum to obtain a white powdery hydroxyl-terminated PLGA for use; Polyester polybutylene adipate (PBA), hexamethylene diisocyanate (HDI) as raw materials, the molar ratio of PLGA, polybutylene adipate (PBA) is l:1, hexamethylene The molar ratio of HDI to PLGA and PBA is l:1, at 160°C and N 2 Under protection, the pressure was reduced to 65 Pa, and ...

Embodiment 3

[0029] D, L-lactide (DLLA), glycolide (GL), 1,4-butanediol, stannous octoate refined by ethanol recrystallization method as raw materials, D, L-lactide (DLLA) , The molar ratio of glycolide (GL) is 6:1, the molar ratio of ethylene glycol to D,L-lactide (DLLA) and glycolide (GL) is l:30, and the catalyst octanoic acid sub Tin (0.1wt%, based on the total mass of DLLA and GL) at 180°C and N 2 Under protection, the pressure was reduced to 70 Pa, and the melt polymerization was carried out for 20 hours. After the reaction is over, add tetrahydrofuran to dissolve, then add methanol to precipitate and purify the product, and dry it in vacuum to obtain a white powdery hydroxyl-terminated PLGA for use; Polyester polyhexamethylene adipate (PHA), lysine diisocyanate (LDI) as raw materials, the molar ratio of PLGA, polyhexamethylene adipate (PHA) is 3:1, lysine diisocyanate (LDI) The molar ratio of isocyanate (LDI) to PLGA and PHA is 2:1, at 180°C and N 2 Under protection, the pressure...

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Abstract

The invention belongs to the technical field of polymer materials, and in particular relates to a degradable shape-memory intraluminal stent and a preparation method thereof. The present invention uses lactide, glycolide or ε-caprolactone, biodegradable polyester and diisocyanic acid as raw materials, and prepares the thermally induced deformation temperature transition point (Ttrans) of about 42°C through bulk melt polymerization. Degradable polymer materials, the obtained materials are processed and shaped above the melting temperature (Tm) to make helical tubular stents for different lumens; under the condition of T>Ttrans, stress is applied, and processed into stents for easy operation Shape; freeze-set stress relief, off-the-shelf product. The shape-memory intraluminal stent prepared by the method of the present invention has good biocompatibility, provides temporary support for the narrow lumen, has no long-term complications and does not need to be taken out after operation, and finally completely degrades in vivo After metabolism, it can be used as a carrier to carry anti-thrombotic and anti-intimal hyperplasia drugs, without the need for long-term systemic anticoagulation and other advantages.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a degradable shape memory endoluminal stent (biodegradable shape memory endoluminal stent) and a preparation method thereof. Background technique [0002] Lumen stenosis is a common clinical disease, and intraluminal stent implantation is currently one of the fastest and most effective methods for treating luminal stenosis. Leakage around the ES is a common complication, and the shape-memory alloy (SMAs) stent developed in recent years has effectively alleviated this problem. There are still certain limitations in its application due to the limitation of vascular endothelial tuberculosis, restenosis, and aneurysm formation or wall perforation caused by medial atrophy caused by long-term compression. Many scientific names have taken into account the potential complications of metal stents and the short-term actual needs, and developed a new generation of ste...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/685C08G63/08A61L31/06A61L31/14
CPCC08G63/6852A61L31/06A61L31/14A61L31/148A61L2300/604A61L2400/16C08G63/08
Inventor 马海清崔成杰谢众
Owner HEILONGJIANG XINDA ENTERPRISE GRP
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