Pre-mixed calcium silicate/magnesium phosphate double-phase composite self-solidification root canal filling material and preparation method and application thereof

A technology of root canal filling and calcium silicate, applied in dental preparations, pharmaceutical formulations, medical science, etc., can solve the problems that are difficult to fully meet clinical needs, cannot promote cementum deposition, does not have solidification and forming characteristics, and achieves convenience The effects of large-scale and mechanized production, shortened solidification time, and simple and easy preparation process

Active Publication Date: 2017-12-01
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many kinds of filling materials clinically used in the treatment of endodontics, but there are some disadvantages: materials such as zinc oxide clove oil cement, GIC, composite resin, etc. do not have biological activity, cannot promote the deposition of cementum, and cannot reach the Physiological sealing effect; cal

Method used

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  • Pre-mixed calcium silicate/magnesium phosphate double-phase composite self-solidification root canal filling material and preparation method and application thereof
  • Pre-mixed calcium silicate/magnesium phosphate double-phase composite self-solidification root canal filling material and preparation method and application thereof
  • Pre-mixed calcium silicate/magnesium phosphate double-phase composite self-solidification root canal filling material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, preparation of premixed calcium silicate / magnesium phosphate composite root canal filling material

[0038] 1. Raw material preparation:

[0039] Magnesium phosphate bone cement powder, including dead burnt magnesia, sodium dihydrogen phosphate. Dead-burned magnesia is obtained by calcining light magnesia at 1500°C for 2 hours, and sodium dihydrogen phosphate is directly used as a purchased reagent. Dead burnt magnesium oxide and sodium dihydrogen phosphate were ball milled for 12 hours respectively, and passed through a 400 sieve. Dead burnt magnesium oxide and sodium dihydrogen phosphate according to the molar ratio of 3.8:1, ball milling and mixing for 12 hours to prepare magnesium phosphate powder.

[0040] As the calcium silicate compound, wind crushed grade tricalcium silicate is selected.

[0041] Glycerin is selected as the water-miscible non-aqueous solvent.

[0042] Zirconia powder is selected as the anti-radiation material, and the particle ...

Embodiment 2

[0046] Embodiment 2, preparation of premixed calcium silicate / magnesium phosphate composite root canal filling material

[0047] 1. Raw material preparation:

[0048] Magnesium phosphate bone cement powder, including dead burnt magnesium oxide, calcium dihydrogen phosphate. The preparation method of dead-burned magnesium oxide is the same as that of Example 1, and calcium dihydrogen phosphate uses purchased reagents. Ball mill dead-burned magnesium oxide and calcium dihydrogen phosphate for 12 hours respectively, pass through 400 sieves, and then ball mill and mix for 12 hours at a molar ratio of 3:1 to prepare magnesium phosphate powder.

[0049] Calcium silicate compounds are selected from wind crushed grade tricalcium silicate and dicalcium silicate.

[0050] The water-miscible non-aqueous solvent is 1,2-propanediol.

[0051] Bismuth oxide powder is selected as the anti-radiation material.

[0052] 2. Compound paste preparation:

[0053] Weigh 0.35g of magnesium phosph...

Embodiment 3

[0054] Embodiment 3, the curing time investigation of composite paste

[0055] 1. Paste preparation:

[0056] Experimental group: the premixed magnesium phosphate / tricalcium silicate composite paste prepared in Example 1 and Example 2.

[0057] Control group 1: Weigh 1g of tricalcium silicate, 1g of zirconia, and 1mL of glycerin, put them into a glass container, mix them mechanically with a stainless steel stirring rod, and fully reconcile them for 10 minutes to obtain a premixed tricalcium silicate compound paste agent. The source and quality of raw material are identical with embodiment 1.

[0058] Control group 2: 0.8g tricalcium silicate powder, 0.2g dicalcium silicate powder, 0.8g bismuth oxide, 0.7mL 1,2-propylene glycol, put into a glass container, mechanically mix with a stainless steel stirring rod, fully After mixing for 5 minutes, a premixed tricalcium silicate / dicalcium silicate composite paste can be obtained. The source and quality of raw material are identic...

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Abstract

The invention provides a pre-mixed calcium silicate/magnesium phosphate double-phase composite self-solidification root canal filling material and a preparation method and application thereof. Magnesium phosphate bone cement powder and at least one calcium silicate compound serve as the main phase, and at least one nonaqueous phase solvent capable of being mixed and dissolved with water and at least one injection-resistance material are added to prepare the root canal filling material with the excellent injectable performance. According to the pre-mixed calcium silicate/magnesium phosphate double-phase composite self-solidification root canal filling material and the preparation method and application thereof, the advantages of magnesium phosphate and calcium silicate materials are combined, so that the solidification time is short, the biological activity is good, and the marginal seal and anti-microbial characteristics are good; and meanwhile clinical application is convenient, and the root canal filling material can serve as the filling material for the field of dental department restoration such as pulp-capping and root canal therapy.

Description

technical field [0001] The invention belongs to the field of medical equipment / biological materials, and in particular relates to a premixed calcium silicate / magnesium phosphate dual-phase composite self-curing root canal filling material and its preparation method and application. Background technique [0002] Pulp capping and root canal therapy are the most common treatment methods for clinical oral endodontics. Pulp capping is suitable for the treatment of clinically diagnosed limited or reversible pulp lesions. Its principle is to cover the dentin surface close to the pulp or the exposed pulp wound surface with preparations that can restore pulp lesions to Protect the pulp and eliminate lesions. Root canal therapy is suitable for clinically diagnosed total or irreversible pulp disease, and its principle is to remove the infected pulp and preserve the living tooth. Although the treatment schemes are different, what they both have in common is that material preparations ...

Claims

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Application Information

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IPC IPC(8): A61K6/02
CPCA61K6/80
Inventor 窦源东郇志广孙先昌常江陈振华
Owner YANTAI ZHENGHAI BIO TECH
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