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Medical use of panoxadiol saponin Rb component in prevention and treatment of diabetic complications and metabolic disorders

A panaxadiol saponin and metabolic disorder technology, which is applied in the field of medicine, can solve the problems of less than 30% of the general population's blood sugar compliance rate, unsuccessful treatment of mitochondrial function defects, etc., and achieves the effect of improving body function and quality of life

Active Publication Date: 2017-12-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

What is even more worrying is that while the prevalence of diabetes in my country continues to increase, the blood sugar compliance rate of the general population is less than 30%.
Despite the central role of mitochondria in human health and disease, treatments for defects in mitochondrial function have been unsuccessful ( Nat Rev Drug Discov. 2013 Jun;12(6):465–483. ; Sci Transl Med. 2016 Feb 17;8(326):326rv3. )

Method used

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  • Medical use of panoxadiol saponin Rb component in prevention and treatment of diabetic complications and metabolic disorders
  • Medical use of panoxadiol saponin Rb component in prevention and treatment of diabetic complications and metabolic disorders
  • Medical use of panoxadiol saponin Rb component in prevention and treatment of diabetic complications and metabolic disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1 Effect of Rb component on blood sugar level and its metabolic characteristics (polydipsia, polyuria, body wasting symptoms) in type I diabetic mice

[0064] Methods: A one-time intraperitoneal injection (i.p.) of streptozotocin (150mg / kg) was used to create a model of type I diabetes in Kunming mice. Model-induced diabetic complications are associated with persistent hyperglycemia and loss of insulin signaling. This provides an opportunity to examine the effect of the tested drug on the metabolic state and complications of diabetes and its mechanism of action from multiple perspectives. Firstly, use this model to observe the improvement effect of Rb component alone or in combination with insulin on pathological characteristics such as polydipsia, polyuria and body weight loss in type I diabetic animals. Qualified 35 mice were divided into normal animal control group, type 1 diabetes model control group, insulin group (2.5IU / kg), Rb component (40mg / kg) treatme...

Embodiment 2

[0073] Example 2 Rb components can promote the damage repair function of diabetic animals

[0074] Methods: In order to reveal the potential medicinal value of Rb component and its combined treatment with hypoglycemic drugs in the prevention and treatment of diabetic foot, the wound repair of animals in each group was observed by using the chronic comprehensive wound model of diabetes. After 5 weeks of drug treatment, the animals were anesthetized with pentobarbital sodium, and then the long mouse hair was removed with electric clippers, and the back hair was removed with depilatory cream. Then disinfect the back skin with povidone iodine, and use scissors in the middle of the back under aseptic conditions to injure a 1.5cm×l.5cm full-thickness skin wound, cut to the subcutaneous fascia, and cover the skin around the wound with gauze after alcohol disinfection. After the operation, the mice were fed in a single cage, free to eat and drink, and the animals in each group continu...

Embodiment 3

[0077] Example 3 The Rb component can improve the motor balance function of diabetic animals—rotarod experiment

[0078] Method: In order to reveal the potential medicinal value of Rb component and its combined treatment with hypoglycemic drugs in the prevention and treatment of diabetic peripheral neuropathy, the exercise balance ability of animals in each group was investigated. After 8 weeks of drug treatment, the motor balance ability of animals in each group was measured with a rotarod instrument. In order not to fall off the rotating rotarod, the animal must maintain an appropriate speed of movement. Therefore, the longer the animal stays on the rotarod, the stronger the animal's ability to exercise balance and exercise muscles. 12 hours after administration, the animal was placed on the fatigue instrument, the rotating speed was set at 15 rpm, and the experiment time was set at 2 minutes. After starting the instrument, the instrument would accelerate uniformly to the se...

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Abstract

The invention provides medical use of a panoxadiol saponin Rb component in the prevention and treatment of diabetic complications and metabolic disorders. A drug is prepared from the panoxadiol saponin Rb component as a single active component or the panoxadiol saponin Rb component and other active compounds, the Rb component mainly contains 50%-98% of five panoxadiol saponins (Rb1, Rb2, Rb3, Rc and Rd), and the other active components include a substance capable of reducing blood glucose level, a traditional Chinese medicine active substance, a natural product, an artificially synthesized compound and an in-vivo active substance. By utilizing independent blood glucose level as an action mechanism, the diabetic metabolic disorders are corrected, the mitochondrial function and oxidation-reduction balance capacity of a diabetic patient can be enhanced, relevant pathological symptoms of mitochondria damage and metabolic disorders caused by pathological factors except diabetes mellitus are resisted, and diseases and pathological symptoms with the metabolic disorders, particularly the mitochondrial functional disorders are prevented and treated. The drug is safe and effective.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of ginseng diol saponin Rb component (hereinafter referred to as Rb component) in the preparation of drugs for preventing and treating diabetes complications and metabolic disorders related diseases. More specifically, using the Rb component to improve the metabolic symptoms of polydipsia, polyphagia and polyuria in diabetic patients, prevent and treat central and peripheral complications of diabetes and other diseases and symptoms related to metabolic disorders (including central nervous degenerative diseases and Neurotoxicity due to cancer therapy). Background technique [0002] Prediabetes and diabetes are recognized as global epidemics. Diabetes and its complications have become the third biggest killer after cardiovascular and cerebrovascular diseases and cancer that threaten human life and health. With the global obesity epidemic and aging world population, a metaboli...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P3/10
CPCA61K31/704A61P25/02A61P25/28A61P25/16A61P25/14A61P25/08A61P25/24A61P25/18A61P3/10A61P17/02Y02A50/30
Inventor 连晓媛张治针池彬彬朱荣遥钱恒
Owner ZHEJIANG UNIV
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