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Magnetic nanoparticle, preparation method and application of magnetic nanoparticle

A magnetic nanoparticle and nanomagnetism technology, applied in the field of nanomaterial medicine, can solve problems such as high Curie temperature, damage to tissue cells, complicated process, etc., and achieve the effects of low Curie temperature, light degree of agglomeration, and simple preparation.

Inactive Publication Date: 2017-12-08
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Curie temperature of iron oxides is mostly high, far exceeding the appropriate temperature (42-48°C) for normal magnetic hyperthermia, so it is necessary to implant a temperature detection device in the tumor area during hyperthermia to control the temperature so as not to damage the normal tissue cells, the process is more complicated

Method used

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  • Magnetic nanoparticle, preparation method and application of magnetic nanoparticle
  • Magnetic nanoparticle, preparation method and application of magnetic nanoparticle
  • Magnetic nanoparticle, preparation method and application of magnetic nanoparticle

Examples

Experimental program
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Effect test

Embodiment 1

[0032] 1) Dissolve 2g of polyvinyl alcohol (molecular weight: 1700) in 70ml of deionized water, soak for 20 hours, then stir and heat to 90°C to completely dissolve the polyvinyl alcohol, and then maintain the temperature at 70°C;

[0033] 2) La (NO 3 ) 3 ·6H 2 O (3.01 mmol, 1.303 g), Sr(NO 3 ) 2 (0.86 mmol, 0.181 g), 50% manganese nitrate solution (4.3 mmol, 1 ml) in 30 ml deionized water, Bi 2 o 3 (0.215 mmol, 0.1 g) was dissolved in 1ml of concentrated nitric acid, then mixed evenly and added to the aqueous solution of polyvinyl alcohol dissolved, the mixed solution was made uniform by magnetic stirring, the pH was adjusted to 7 by adding ammonia water, and the temperature was maintained at 70°C until the water slowed down. Slow evaporation forms a viscous liquid. Put the viscous liquid above into an oven for drying at 80°C, put the dried dry gel into a resistance furnace to raise the temperature to 800°C at a heating rate of 5°C / min, keep it at 800°C for 5 hours, and...

Embodiment 2

[0045] 1) Dissolve 2g of polyvinyl alcohol (molecular weight: 1750) in 70ml of deionized water, soak for 15 hours, then stir and heat to 100°C to completely dissolve the polyvinyl alcohol, and then maintain the temperature at 70°C;

[0046] 2) La (NO 3 )3 ·6H 2 O (3.01 mmol, 1.303 g), Sr(NO 3 ) 2 (0.86 mmol, 0.181 g), 50% manganese nitrate solution (4.3 mmol, 1 ml) in 30 ml deionized water, Bi 2 o 3 (0.215 mmol, 0.1 g) was dissolved in 1ml of concentrated nitric acid, then mixed evenly and added to the aqueous solution of polyvinyl alcohol dissolved, the mixed solution was made uniform by magnetic stirring, and ammonia water was added to adjust the pH to 7.5, and then the temperature was maintained at 80°C until the water slowed down. Slow evaporation forms a viscous liquid. Put the viscous liquid above into an oven for drying at 80°C, put the dried dry gel into a resistance furnace to raise the temperature to 800°C at a heating rate of 5°C / min, keep it at 800°C for 8 hou...

Embodiment 3

[0049] 1) Dissolve 2g of polyvinyl alcohol (molecular weight: 1800) in 70ml of deionized water, soak for 24 hours, then stir and heat to 90°C to completely dissolve the polyvinyl alcohol, and then maintain the temperature at 80°C;

[0050] 2) La (NO 3 ) 3 ·6H 2 O (3.01 mmol, 1.303 g), Sr(NO 3 ) 2 (0.86 mmol, 0.181 g), 50% manganese nitrate solution (4.3 mmol, 1 ml) in 30 ml deionized water, Bi 2 o 3 (0.215 mmol, 0.1 g) was dissolved in 1ml of concentrated nitric acid, and then mixed evenly and added to the aqueous solution of polyvinyl alcohol dissolved, and the mixed solution was made uniform by magnetic stirring, and the pH was adjusted to 8 by adding ammonia water, and the temperature was maintained at 70°C until the water was slow Slow evaporation forms a viscous liquid. Put the viscous liquid above into an oven for drying at 70°C, put the dried dry gel into a resistance furnace and raise the temperature to 850°C at a heating rate of 8°C / min, keep it at 850°C for 5 h...

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to a La0.7Sr0.2Bi0.1MnO3 magnetic nanoparticle, a preparation method and an application of the magnetic nanoparticle. The sodium hyaluronate modified La0.7Sr0.2Bi0.1MnO3 magnetic nanoparticle serves as a magnetic thermal therapy medium, a magnetic fluid takes the La0.7Sr0.2Bi0.1MnO3 magnetic nanoparticle as a core, and the surface of the magnetic nanoparticle is modified by the sodium hyaluronate to form stable magnetic hydrosol. The magnetic thermal therapy medium has good biocompatibility and chemical stability and high magnetic heating performance, can effectively kill cancer cells and has a wide application prospect in magnetic thermal therapy and thermo-chemotherapy combination and anti-tumor diagnosis and treatment integration.

Description

technical field [0001] The invention belongs to the medical field of nanomaterials, in particular to a magnetic nanoparticle with high magnetocaloric effect and low Curie temperature, its preparation method and application. Background technique [0002] Magnetic hyperthermia refers to positioning the magnetic medium in the tumor area, and applying an alternating magnetic field outside the body, so that the magnetic medium converts magnetic energy into heat energy through hysteresis and relaxation, and then heats the tumor area to 42°C-48°C to kill the tumor. A novel therapy to kill or suppress cancer cells. Magnetic nanoparticles have attracted extensive research by researchers since the concept of magnetic hyperthermia was proposed in 1957. Compared with radiotherapy and chemotherapy, magnetic hyperthermia has the advantages of high targeting, few side effects, minimally invasive or even non-invasive. As the magnetic nanoparticles, iron, cobalt, nickel or their alloys or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/059H01F1/00A61K41/00A61K47/36A61K9/00A61K9/51
Inventor 王颖陈园伟王涛
Owner LANZHOU UNIVERSITY
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