Alginate filler strip and preparation method and application thereof

An alginate and filling strip technology, applied in the field of medical materials, can solve the problems of difficulty in filling, infection, limited absorption, etc., and achieve the effects of improving relative moisture retention, promoting absorption capacity, and good ventilation.

Active Publication Date: 2017-12-29
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For wounds or sinus tracts with cavities, the wound site is prone to exudation after surgery, and the wound should not be exposed to the air for a long time, otherwise it is easy to cause infection. Conventional wound dressings have short service life, poor air permeability, and limited absorption. It is easy to cause redness, swelling, oozing and other adverse reactions, which will affect the healing of the wound
At present, gauze dressings, mesh dressings and antibacterial dressings are used clinically for surgery and sinus wound filling, but they cannot solve the comprehensive ventilation of the wound, the absorption of exudate and the scarring of the wound at the same time, resulting in poor treatment effect
And common gauze dressing is more difficult to fill, is not easy to operate, brings certain misery to the patient

Method used

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  • Alginate filler strip and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: Preparation of alginate filling strip according to the present invention

[0037] Dissolve sodium alginate in a solution using a mixed solution of purified water and ethanol (1:1 by mass percentage) as a solvent, add sodium carboxymethyl cellulose, stir well, and make sodium carboxymethyl cellulose with a mass percentage of 1.2%, 4% alginate solution by mass percentage of alginate; prepare 10% pectin aqueous solution by mass percentage.

[0038] Mix the above-mentioned pectin aqueous solution and alginate solution at a volume ratio of 1.5:10, stir the mixed solution vigorously until it forms a homogeneous system, and use it as an alginate spinning stock solution, and place it in an additional circle between the microinjector and the patterned electrode. ring patterned electrode electrospinning device in a microinjector;

[0039] At a temperature of 25°C and a humidity of 45%, adjust the microinjector to 0.1-0.12ml / h, adjust the ring voltage to 4.5KV, adju...

Embodiment 2

[0043] Example 2: Tests on water absorption, gelation properties and dispersion properties of different filling strips

[0044] 1. Test object

[0045] Group 1: Filling strips according to Embodiment 1 of the present invention;

[0046] Group 2: Other commercially available alginate filling strips (strip dressings made of other alginate fibers through wet spinning, in line with the third category of medical devices exempted from clinical trials announced by the State Food and Drug Administration Catalog and pharmaceutical industry standard YY / T 1293.5-2017 "Contact Wound Dressing Part 5: Alginate Dressing" requirements);

[0047]The 3rd group: use the raw material in the embodiment 1 of the present invention, according to the filling strip prepared by wet spinning process;

[0048] Group 4: Filling strips prepared according to the method described in Example 1 of patent CN103060946A;

[0049] 2. Results

[0050] The above 4 groups of objects were tested for water absorptio...

Embodiment 3

[0054] Embodiment 3: Moisture retention test of different filling strips

[0055] With reference to the test object of embodiment 2 and add cotton gauze test object (cotton gauze is the 5th group), cut each group of samples (2 ± 0.1) g respectively, after each sample is tiled respectively in the petri dish that diameter is 100mm and keep the sample flat; use a dropper to evenly drop simulated body fluid 5 times the mass of each sample on the surface of the sample, and then weigh it immediately; place each petri dish at 37°C and humidity of (60±15)%. Leave it on, weigh every 1d, and evaluate the moisture retention performance of each sample. The test results are shown in Table 2.

[0056] Moisture retention rate = (initial mass - weighed mass) / water mass in simulated body fluid x 100%

[0057] Table 2

[0058]

[0059] It can be seen from the data in Table 2 that although the moisture retention rate of each group gradually decreases over time, the moisture retent...

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Abstract

The invention relates to the technical field of medical materials and discloses an alginate filler strip and an application method and application thereof. The alginate filler strip is prepared by soaking spinning fiber formed by alginate, pectin and sodium carboxymethylcellulose in a calcium chloride solution, subjecting the spinning fiber to freeze-drying, opening, carding and top making and pressing the spinning fiber to be round-spindle shaped. The alginate, the pectin and the sodium carboxymethylcellulose are taken as the raw materials to form a novel dressing with the round-spindle shaped compression structure by the aid of an electrostatic spinning process, adsorptive capacity of the dressing on seepages and moisture-retaining capacity on wounds are promoted physicochemically, and remarkable advantages in the application of medical dressings are achieved.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an alginate filling strip and its preparation method and application. Background technique [0002] For wounds or sinus tracts with cavities, the wound site is prone to exudation after surgery, and the wound should not be exposed to the air for a long time, otherwise it is easy to cause infection. Conventional wound dressings have short service life, poor air permeability, and limited absorption. It is easy to cause redness, swelling, oozing and other adverse reactions, which will affect the healing of the wound. At present, gauze dressings, mesh dressings and antibacterial dressings are used clinically for surgery and sinus wound filling, but they cannot solve the comprehensive ventilation of the wound, the absorption of exudate and the scarring of the wound at the same time, resulting in poor treatment effect. And common gauze dressing filling is more difficult, is n...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/60D01D5/00
Inventor 赵澎张聪车七石刘少辉
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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