Preparation method and applications of polypyrrole functional nanoparticles stabilized with protein

A technology of functional nanoparticles and polypyrrole, which is applied in the fields of materials science and biomedicine, can solve the problems of limiting the clinical application of multifunctional photothermal agents, PPy is chemically inert, and lacks reactive sites, etc., and achieves excellent MRI effects, excellent Effect of photothermal performance, high clinical research value
CN107674433AActive Publication Date: 2018-02-09HUBEI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUBEI UNIV
Publication Date
2018-02-09

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Abstract

The invention discloses a preparation method and applications of polypyrrole functional nanoparticles stabilized with a protein, and belongs to the field of material science and biomedical application. According to the preparation method, water soluble bovine serum albumin (BSA) is taken as a stabilizing agent, potassium peroxydisulfate (KPS) is taken as an initiator, initiation of pyrrole monomerpolymerization is carried out, gadolinium ions (Gd3+) are introduced into a polypyrrole nanoparticle dispersion liquid stabilized by the protein, simulative biomineralization is adopted so as to realize in-suit generation of gadolinium oxide (Gd2O3) in polypyrrole nanoparticles stabilized by the protein. Synchronous diagnosis and treatment is realized, the polypyrrole functional nanoparticles stabilized with the protein possess excellent Ti modal MRI effect and light-heat properties, the preparation method is simple, reaction conditions are mild, the repeatability is high, and popularizationis convenient.
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Description

technical field

[0001] The invention belongs to the field of material science and biomedicine, and in particular relates to a preparation method and application of functional nanoparticles integrating nuclear magnetic resonance imaging (MRI) and photothermal therapy (PTT). Background technique

[0002] In recent years, photothermal therapy has become a research hotspot in the field of tumor treatment due to its advantages of less trauma and less toxic side effects. PTT is the use of related photothermal therapeutic agents to absorb near-infrared light with low energy and strong tissue permeability and convert it into sufficient heat. The local high temperature (>43°C) in the tumor area directly leads to tumor cell apoptosis and tumor growth. A treatment method for tissue necrosis, in which the performance of photothermal agents plays a decisive role in the therapeutic effect. Polypyrrole (PPy) stands out in the research of photothermal agents for its excellent phototherma...

Claims

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