Surface plasma nano-drug carrier and preparation method and application thereof

A nano-drug carrier, surface plasmon technology, which is applied in the photodissociation of drugs in the body, drug combinations, pharmaceutical formulations, etc., to achieve the effects of improving therapeutic efficacy, excellent stability, and increased permeability

Active Publication Date: 2018-03-13
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there are few literature and patent reports on the assembly of gold nanorods through ionic liquid microgels and their application in the combination of chemotherapy and photothermal therapy to fight cancer.

Method used

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  • Surface plasma nano-drug carrier and preparation method and application thereof
  • Surface plasma nano-drug carrier and preparation method and application thereof
  • Surface plasma nano-drug carrier and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0086] The preferred surface plasmon nano drug carrier preparation method of the present invention comprises the following steps:

[0087] (1) The amount of N-isopropylacrylamide added is 4-10 times that of azobisisobutylamidine hydrochloride; the amount of 1-vinylimidazole added is 0.1-0.5 times that of N-isopropylacrylamide; The amount of 1,6-dibromohexane added is 0.7-2.0 times that of azobisisobutylamidine hydrochloride; 30-60 minutes of nitrogen gas flow, 65-75 ° C, 4-6 hours of polymerization reaction and cooling to room temperature.

[0088] (2) centrifuging the reaction solution in step (1), allowing the nanoparticles therein to settle, and removing unreacted monomers and initiators in the supernatant. Then cetyltrimethylammonium bromide, aqueous chloroauric acid and sodium borohydride were added. Rapid magnetic stirring for 2 minutes, placed at 25°C for aging.

[0089] (3) After the above step (2) is completed, a growth solution is prepared. Add cetyltrimethylammo...

Embodiment 1

[0099] The preparation of embodiment 1 surface plasmonic nanocarrier

[0100] 1) Preparation of ionic liquid microgels

[0101] In a 100 mL three-neck flask, add 0.1132 g of N-isopropylacrylamide (NIPAM) and 27 μL of 1-vinylimidazole (VIM) into 45 mL of water for three times, heat to 70 ° C, stir with a magnetic sub, blow nitrogen for 20 minutes, and then use a syringe to After adding 5 mL of 5 mg / mL azobisisobutylamidine hydrochloride aqueous solution for 10 minutes, add 1 mL of 1,6-dibromohexane (1,6-dibromohexane) in N,N-dimethylformamide aqueous solution (46 μL), react at 70° C. for 6 hours under nitrogen atmosphere. Obtain thermosensitive ionic liquid microgels (such as figure 1 shown), other synthetic conditions figure 2 shown. The electron microscope sample is prepared by centrifuging the material solution, washing it once with methanol and water, and then dropping it onto a copper grid containing a common carbon film to dry it and then observe it.

[0102] 2) Pre...

Embodiment 2

[0107] This example is used to illustrate the absorption of the surface plasmonic nanocarriers in the near-infrared region.

[0108] Take respectively the ionic liquid microgel and the surface plasmon nanocarrier aqueous solution in Example 1, and place them in the cuvette of the ultraviolet-visible absorption spectrum successively, and measure the ultraviolet light of the ionic liquid microgel and the surface plasmon nanocarrier from 400nm to 1000nm. Absorb, and draw curves. Figure 5 It is shown that the ionic liquid microgel does not show obvious absorption in the measured area, but the surface plasmon nanocarrier has obvious absorption at 520nm and 800nm, showing the properties of the surface plasmon nanocarrier surface plasmon.

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Abstract

The invention discloses a surface plasma nano-drug carrier and a preparation method and application thereof. The surface plasma nano-drug carrier comprises an ionic liquid microgel and gold nanorods adhered to the surface of the ionic liquid microgel, wherein the ionic liquid microgel is a copolymer of N-isopropylacrylamide and 1-vinyl imidazole, and the grain diameter is 200 to 500 nm; the lengths of the gold nanorods are 50 to 200 nm, and the length-diameter ratio is 1.5 to 20. According to the nano-drug carrier, a material with a surface plasma characteristic is assembled, and the phenomenon of surface plasma resonance coupling can occur, so that the capacity of photothermal conversion is strengthened, the treatment method that photo-thermal treatment is combined with chemical treatmentis realized through near-infrared laser radiation, the effect of synergistic interaction can be achieved, the respective disadvantages of the two treatment methods are also overcome, and an optimal treatment effect is achieved; by adopting the method of tumor targeting treatment through external energy stimulation, the locus, opportunity and strength of external stimulation can be accurately controlled conveniently.

Description

technical field [0001] The invention belongs to the technical field of drug carriers, in particular to a surface plasmon nano drug carrier and its preparation method and application, in particular to a surface plasmon nano drug carrier based on gold nanorods, its preparation method and its application in the field of cancer treatment Applications. Background technique [0002] In the past few decades, although people's understanding of cancer has made great progress, cancer is still one of the major diseases affecting human health and life expectancy. According to the 2017 China Cancer Registration Annual Report, about 10,000 people in my country are diagnosed with cancer every day; about 7 people are diagnosed with cancer every minute. The high mortality rate of cancer is largely due to the poor effect of traditional cancer treatment. In the prior art, anticancer drugs cannot simply be transported to the tumor area to cause adverse reactions to healthy tissues and organs. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/52A61K47/32A61K41/00A61K31/704A61P35/00A61K9/19
CPCA61K9/19A61K31/704A61K41/0042A61K41/0052A61K47/32A61K2300/00
Inventor 董姝丽王益彤郝京诚
Owner SHANDONG UNIV
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