Enteromorpha margin oligosaccharide with blood glucose reducing function as well as preparation method and application thereof

Abstract

The invention discloses enteromorpha margin oligosaccharide with a blood glucose reducing function as well as a preparation method and application thereof. The invention provides an enteromorpha margin oligosaccharide mixture with the blood glucose reducing effect; enteromorpha margin from the production place of Qingdao is degraded into enteromorpha margin oligosaccharide with the molecular weight range being 1000Da to 10000Da; the efficacy of improving the diabetes is achieved; the enteromorpha margin oligosaccharide can be used for medicine preparations for relieving type I diabetes mellitus or health care food in various modes or paths.

Description

technical field [0001] The invention belongs to the technical field of health food and food, and in particular relates to an enteromorpha oligosaccharide with the function of lowering blood sugar and its preparation method and application. Background technique [0002] Diabetes is a metabolic disorder in which the body maintains high blood sugar levels for a long period of time. The typical symptoms are polyphagia, polydipsia, polyuria and weight loss (three more and one less). If left untreated, diabetes can cause a variety of complications, which can be chronic, such as cardiovascular disease, stroke, chronic kidney disease, foot ulcers, and eye damage, or acute, such as diabetic ketoacidosis, hyperosmolarity Sexual nonketotic diabetic coma or even death. Diabetes is broadly classified according to its etiology: (1) Type I diabetes, in which the pancreas produces very little insulin; and (2) Type II diabetes, in which cells do not respond sensitively to insulin (insulin r...

AI Technical Summary

Problems solved by technology

[0011] Among the currently disclosed polysaccharide patents derived from Enteromorpha, CN105567762A discloses that microwave-assisted degradation of Enteromorpha oligosaccharides has a hypoglycemic effect, and it is only suitable for the production of oligosaccharides, not suitable for the production of polysaccharides with larger molecular weights. Extraction; CN105695537A discloses a glycosylated enteromorpha oligosaccharide that lowers blood sugar and regulates intestinal flora

For Enteromorpha oligosaccharides between Enteromorpha oligosaccharides and Enteromorpha polysaccharides, its hypoglycemic activity and application methods have not yet been reported or patented, but its protein removal process uses trifluorotrichloroethane, three Toxic reagents such as chloroacetic acid are not suitable for the food production process, and the glycosylation process of the extracted oligosaccharide salt also increases the production cost

[0012] Enteromorpha oligosaccharide prepared in Chinese patent application CN102775512A utilizes 100 degree of boiling water to cook and reflux for 4h, which is unfavorable for retaining polysaccharide activity, and its main products (mannose, fucose, glucose, galactose, arabinose, xylose) There is room for improvement in blood sugar lowering efficacy

[0013] Chinese patent application CN106519059A uses water temperature of 80-105 degrees to cook for 1-3 hours to treat the substrate, and the temperature is high, which is not conducive to retaining polysaccharide activity.

[0014] In the Chinese patent application CN106819704A, there is only a warm water extraction step and a lack of impurity removal steps, resulting in complex product components when faced with different substrates. The products obtained by this method include small molecular peptides, non-sugar compounds

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