Polylactic-acid-based bone tissue support loading icariin and deferoxamine and preparation method and application of polylactic-acid-based bone tissue support

Abstract

The invention belongs to the field of a biomedical material, and specifically relates to a polylactic-acid-based bone tissue support loading icariin and deferoxamine, and a preparation and applicationof the polylactic-acid-based bone tissue support. Electrospinning technique is adopted to prepare a polylactic acid micrometer fiber support, which is then modified with a polydopamine layer, and finally, polydopamine is used for synergetic fixing of icariin and deferoxamine to the support. Through utilization of polydopamine, the hydrophilic performance, mechanical properties and cell affinity of the support are improved, and through cooperation of icariin and deferoxamine, the ossification performance and hematopoietic performance of the support are greatly improved. Through further adoption of thermally-induced phase separation, a chitosan nanometer fiber net is compounded on the polylactic acid micrometer fiber support, and based on the composite nanometer fiber net, polydopamine, icariin and deferoxamine are used for modification. The mechanical property of the support is obviously improved, which is beneficial for forming vasoganglion. The used materials are cheap, the adopted electrospinning and thermally induced phase separation technology are simple, and the performance of the material is easy to regulate, so that the support is suitable for industrialization.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a polylactic acid-based bone tissue scaffold loaded with icariin and deferoxamine, a preparation method and application thereof. Background technique [0002] Bone defects and bone injuries caused by various reasons are common clinical problems in medicine. Bone implantation is a common treatment for this problem, thus resulting in an urgent and huge market demand for bone repair materials. Polylactic acid has good biocompatibility, adjustable degradation rate and plasticity, so it has become an important class of bone repair materials. However, polylactic acid has disadvantages such as poor mechanical properties, poor hydrophilicity, lack of osteoconductivity and osteoinductivity, and no ability to angiogenesis, which severely limits its application as a bone tissue scaffold. Therefore, in order to overcome the above defects, on the one hand, it is necessary to ...

AI Technical Summary

Problems solved by technology

Modification of deferoxamine on the surface of polylactic acid film is beneficial to the adhesion, spreading and proliferation of endothelial cells, and improves the angiogenesis ability of the material (Liu, Hua, etal. Materials Science and Engineering: C, 2017, 79: 399-409. ) However, the above studies only improved the osteogenic activity or angiogenesis ability of polylactic acid materials, and the degree of improvement was very limited.

In addition, the prepared scaffold material is a membrane layer, which does not have a hierarchical structure with good mechanical properties and is conducive to the formation of vascular network

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