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Pluronic-modified molybdenum oxide nano-sheet as well as preparation method and application thereof

A pluronic and nanosheet technology, which is applied in non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of reducing blood circulation time and EPR effect, reducing tumor treatment effect, Material enrichment reduction and other problems, to avoid long-term in vivo toxicity, strong photothermal conversion effect, and good biological safety.

Active Publication Date: 2018-08-28
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ultra-small nanoparticles avoid long-term toxicity through rapid excretion, and also reduce their blood circulation time and EPR effect, resulting in reduced enrichment of nanomaterials at tumor sites and reduced tumor therapeutic efficacy.

Method used

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  • Pluronic-modified molybdenum oxide nano-sheet as well as preparation method and application thereof
  • Pluronic-modified molybdenum oxide nano-sheet as well as preparation method and application thereof
  • Pluronic-modified molybdenum oxide nano-sheet as well as preparation method and application thereof

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preparation example Construction

[0033] In a typical embodiment of the present invention, the preparation method of the MoOx nanosheet of described Pluronic modification is provided, comprises the steps:

[0034] Add Pluronic to the organic solvent dispersion of MoOx nanosheets for ultrasonic treatment, remove the organic solvent after ultrasonic treatment, then add water, continue ultrasonic treatment to obtain the aqueous dispersion of Pluronic@MoOx, and finally perform centrifugation to remove untreated particles. Reaction of Pluronic to obtain Pluronic-modified MoOx nanosheets.

[0035] In a preferred embodiment of the present invention, a method for preparing MoOx nanosheets is provided, which includes: firstly synthesizing hydrophobic monolayer MoOx nanosheets with large particle size by a one-pot hydrothermal method, and then ultrasonically transforming them Broken into nano fragments to obtain MoOx nanosheets with the desired small particle size.

[0036] The MoOx nanosheets prepared by the one-pot hyd...

Embodiment 1

[0067] Synthesis of Molybdenum Oxide Nanosheets Modified by Pluronic

[0068] (1) Synthesis of MoOx nanosheets: Accurately weigh 1.2359 g (1 mmol) of ammonium molybdate, dissolve it in 13 ml of deionized water, and then add 1.2 ml of 1 mol / L hydrochloric acid solution. Another 0.8 g of oleylamine was dissolved in 4 ml of cyclohexane, and under the action of magnetic stirring, the cyclohexane solution of oleylamine was slowly added to the ammonium molybdate solution, and stirred vigorously overnight to form a white emulsion. The white emulsion was transferred to a 25ml polytetrafluoroethylene-lined reactor and reacted at 180°C for 12h. Naturally cool to room temperature after the reaction, add 20ml cyclohexane to extract the MoOx nanosheets, then add 40ml of absolute ethanol to precipitate the MoOx nanosheets, remove the supernatant, and repeatedly remove impurities to obtain dark blue MoOx nanosheets and remove them. Disperse in dichloromethane for later use. The results of ...

Embodiment 2

[0071] Preparation of DOX-loaded F127-modified MoOx nanosheets (MoOx@F127 / DOX)

[0072]Disperse or dissolve appropriate amount of MoOx, DOX and F127 in dichloromethane-ethanol (5:1, V / V) to prepare 3mg / ml MoOx dispersion, 3mg / ml DOX and 6mg / ml F127 solution. Mix 1ml of MoOx dispersion and 1ml of DOX solution, add 3ml of dichloromethane-ethanol solution and stir in the dark for 12h, then add 1ml of F127 solution and continue to stir for 12h, the probe is sonicated for a few minutes, and the organic solvent is removed by rotary evaporation, and then Add water and ultrasonically disperse, and centrifuge to remove unencapsulated DOX. With the same concentration of MoOx@F127 solution as a blank control, the absorbance value at 481nm was measured by UV-visible spectrophotometry and the drug loading rate was calculated (DLE (%)=(W LoadedDOX / W MoOx )×100%), the results showed that the drug loading rate was 46.9%.

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Abstract

The invention discloses a Pluronic-modified molybdenum oxide nano-sheet as well as a preparation method and application thereof. The Pluronic-modified molybdenum oxide nano-sheet has good biological safety, strong photo-thermal conversion effect, high drug loading capacity and PH-dependent biodegradability and can be used as a drug carrier to increase the solubility of a hydrophobic anti-cancer drug and improve the distribution of the hydrophobic anti-cancer drug in a body; the tumor target enrichment ability of the Pluronic-modified molybdenum oxide nano-sheet is improved; the tumor photo-thermal therapy or the chemotherapy-the photo-thermal combined therapy can be realized in combination with near-infrared irradiation, so that the tumor therapeutic effect is improved, and toxic and sideeffects are reduced.

Description

technical field [0001] The invention relates to a Pluronic-modified molybdenum oxide (MoOx) nanosheet and a preparation method and application thereof, belonging to the field of biomedical materials and nanometer pharmaceutical preparations. Background technique [0002] Traditional cancer treatment methods mainly include: chemotherapy, radiotherapy and surgery. The specificity of chemotherapy and radiotherapy is poor. While killing cancer cells, it will also damage normal cells. The toxic side effects are obvious, and long-term chemotherapy will also produce tumors. drug resistance. Surgical treatment is risky, incomplete, and prone to recurrence. Therefore, it is of great significance to develop new anti-tumor methods with high specificity, low side effects and high therapeutic efficiency. Photothermal therapy is an emerging non-invasive tumor treatment method, which uses the interaction between light absorbers distributed in tumor tissue and near-infrared light to conve...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K41/00A61K31/704A61K47/10A61K47/02A61P35/00
CPCA61K9/5115A61K9/5146A61K31/704A61K41/0052A61K2300/00
Inventor 翟光喜陈钰娟
Owner SHANDONG UNIV
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