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Preparation of nano silver wire/nitrogen-doped multi-wall carbon nanotube composite electrode and method for determining glucose by using same

A multi-walled carbon nanotube and nanosilver wire technology, applied in the field of electroanalytical chemistry, can solve the problems of poor reproducibility, low sensitivity, and difficulty in accurate quantitative analysis, and achieve high sensitivity and reproducibility, high sensitivity, and easy operation. Effect

Inactive Publication Date: 2018-10-30
DALIAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current methods for glucose determination have defects such as low sensitivity and poor reproducibility, and electrochemical methods are prone to secondary environmental pollution.
For example: film titration, glucose oxidase-peroxidase colorimetric method has low sensitivity and is difficult to accurately quantitatively analyze
Optical and chromatographic methods use expensive instruments and are not convenient for on-site detection

Method used

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  • Preparation of nano silver wire/nitrogen-doped multi-wall carbon nanotube composite electrode and method for determining glucose by using same
  • Preparation of nano silver wire/nitrogen-doped multi-wall carbon nanotube composite electrode and method for determining glucose by using same
  • Preparation of nano silver wire/nitrogen-doped multi-wall carbon nanotube composite electrode and method for determining glucose by using same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Fabrication of PDMS flexible substrate, using photolithography technology to fabricate the substrate. Firstly, use AutoCAD 2014 software to design the electrode drawing, and use the typesetting machine to print the drawing as a mask, and then spin-coat photoresist on the surface of the clean silicon wafer to cover the mask containing the electrode pattern, and finally perform exposure and development. Obtain a silicon wafer template (24 electrode templates can be photoetched on the surface of a silicon wafer). Place the silicon wafer template in a disposable petri dish; pour a PDMS mixed solution with a mass ratio of 10:1 on it; then put it in a vacuum desiccator to vacuum out the air bubbles in the PDMS mixed solution for 2 hours; after taking it out Put it into a constant temperature oven at 80°C for heating and curing for 1 hour, and cut it into 24 electrode substrates; treat the prepared substrates with adhesive tape (purchased from 3M Company in the United State...

Embodiment 2

[0032] A three-electrode system is adopted: the carbon nanotube composite electrode prepared in Examples 1-4 is used as the working electrode, the Ag / AgCl electrode is used as the reference electrode, and the platinum wire is used as the auxiliary electrode, and a 0.1mol / L NaOH solution is detected by differential pulse voltammetry To support the electrolyte, use an electrochemical workstation to record the peak current and differential pulse voltammetry curves of the diluted glucose injection in the range of -0.3 to 0.2V.

[0033] attached figure 2 is the optimization curve for carbon nanotube species. The experiments explored the detection of hydroxylated multi-walled carbon nanotubes, carboxylated multi-walled carbon nanotubes, nitrogen-doped multi-walled carbon nanotubes, and multi-walled carbon nanotubes in 1mmol / L glucose solution with 0.1mol / L NaOH solution as the supporting electrolyte. Differential pulse voltammetry curve, the results show that the peak current of t...

Embodiment 3

[0035] A three-electrode system is adopted: the nano-silver wire / nitrogen-doped multi-walled carbon nanotube composite electrode prepared in Example 4 is used as the working electrode, the Ag / AgCl electrode is the reference electrode, and the platinum wire is the auxiliary electrode. Differential pulse voltammetry is used. The test uses 0.1mol / L NaOH solution as the supporting electrolyte, and records the peak current and differential pulse voltammetry curve of the diluted injection glucose in the range of -0.3-0.2V with an electrochemical workstation.

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Abstract

The invention relates to the preparation of a nano silver wire / nitrogen-doped multi-wall carbon nanotube composite electrode and a method for determining glucose by using the same. The electrode comprises a working electrode, a reference electrode, an auxiliary electrode and an electrochemical workstation, wherein the working electrode is based on PDMS, with nano silver wires as a conductive layerand nitrogen-doped carbon nanotube particles as a reaction catalytic layer; an Ag / AgCl is taken as an electrode of the reference electrode, and the auxiliary electrode is a platinum wire. By utilizing the good flexibility of the PDMS, and combining the good conductivity of the silver nano wires and the good response of nitrogen-doped multi-walled carbon nanotubes to the glucose, the electrode with high sensitivity to glucose is obtained. Compared with other methods, the method is relatively high in sensitivity and reproducibility for the determination of the glucose, low in test cost and freeof secondary environmental pollution, and can be widely used for analysis and determination.

Description

technical field [0001] The invention relates to the technical field of electroanalytical chemistry, in particular to a method for preparing and measuring a novel electrode that can be used for measuring glucose. Background technique [0002] Glucose is an important component in the blood of animals and humans. Blood sugar needs to be kept at a certain concentration to meet the needs of various organs and tissues in the body. Low blood sugar concentration can easily cause hypoglycemia, and high blood sugar concentration can easily cause diabetes. Therefore, fast and convenient blood glucose measurement technology plays a vital role in realizing the monitoring of blood glucose concentration in animals and humans, and then protecting their health. For the detection methods of glucose, there are mainly Fehling method, glucose oxidase-peroxidase colorimetric method, and optical, electrochemical and other analytical methods. Among them, due to the diversification of electrochemic...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/327
CPCG01N27/30G01N27/3278
Inventor 孙晶刘洋
Owner DALIAN UNIVERSITY
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