Biological stain-resistant coating with long-acting super-hydrophilic performance and preparation method thereof

A super-hydrophilic, high-performance technology, applied in the field of medical materials, can solve the problems that hydrophilic molecules or groups cannot perform their functions, and achieve the effects of solving adverse reactions of organisms, simple operation, and excellent adhesion

Active Publication Date: 2018-11-16
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the above-mentioned problems in the prior art, the present invention provides a biological antifouling coating with long-lasting superhydrophilic properties and a preparation method thereof, which can effectively solve the problem of additionally introducing hydrophilic materials in order to improve the compatibility of biological materials and cells. Sexual molecules or groups, while hydrophilic molecules or groups cannot perform their functions after being inactivated or lost in large quantities during service

Method used

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  • Biological stain-resistant coating with long-acting super-hydrophilic performance and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] A biological antifouling coating with long-lasting superhydrophilic properties, the preparation method of which comprises the following steps:

[0024] (1) Polishing, cleaning and drying medical stainless steel materials;

[0025] (2) Place the stainless steel material after the above treatment in the acetic acid-acetate buffer solution with a pH value of 4, then add gallic acid, L-arginine and concentrated nitric acid with a mass fraction of 65%-68%, gallic acid The final concentrations of acid, L-arginine and concentrated nitric acid were 0.01mg / mL, 0.01mg / mL and the mass fraction was 34% respectively, and then reacted at 40°C for 30h;

[0026] (3) Submerge the product obtained in step (2) in deionized water, ultrasonically clean it 3 times for 5 minutes each time, and then dry it under nitrogen to obtain the obtained product.

Embodiment 2

[0028] A biological antifouling coating with long-lasting superhydrophilic properties, the preparation method of which comprises the following steps:

[0029] (1) polishing, cleaning and drying the nickel-titanium alloy material;

[0030] (2) Place the nickel-titanium alloy material after the above treatment in a phthalic acid-hydrochloric acid buffer solution with a pH value of 3.5, then add epigallocatechin gallate (EGCG), ethylenediamine and trichloride The final concentrations of iron solution, epigallocatechin gallate (EGCG), ethylenediamine and ferric chloride solution are 1mg / mL, 4mg / mL and 2mg / mL respectively, and then react at 25°C for 2h;

[0031] (3) Submerge the product obtained in step (2) in deionized water, ultrasonically clean it 3 times for 5 minutes each time, and then dry it under nitrogen to obtain the obtained product.

Embodiment 3

[0033] A biological antifouling coating with long-lasting superhydrophilic properties, the preparation method of which comprises the following steps:

[0034] (1) cleaning and drying the polytetrafluoroethylene material;

[0035] (2) Place the polytetrafluoroethylene material after the above treatment in 2-(N-morpholine) ethanesulfonic acid buffer solution with a pH value of 6, then add epicatechin gallate (ECG), 1, 8-diaminooctane and sodium periodate solution, the final concentrations of epicatechin gallate (ECG), 1,8-diaminooctane and sodium periodate solution are 2mg / mL and 4mg / mL, respectively and 4mg / mL, then react at 15°C for 24h;

[0036] (3) Submerge the product obtained in step (2) in deionized water, ultrasonically clean it 3 times for 5 minutes each time, and then dry it under nitrogen to obtain the obtained product.

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Abstract

The invention provides a biological stain-resistant coating with long-acting super-hydrophilic performance and a preparation method thereof. The preparation method comprises the following steps that pre-treatment is conducted on the surface of a base material; the treated base material is placed in slightly acidic buffer liquid, and then a polyphenol compound, a polyamine-based compound and an oxidizing agent are added for reaction; a reaction product is immersed in deionized water for ultrasonic cleaning, and then under a nitrogen condition, drying is conducted to obtain the biological stain-resistant coating with the long-acting super-hydrophilic performance. The method is simple to operate and mild in reaction condition, a prepared coating material has the polyphenol compound and a large amount of functional groups of carboxyl, phenolic hydroxyl, quinonyl, amido and the like, and the surface of the coating shows the long-acting super-hydrophilic performance. The adhesiveness betweenthe modified coating prepared by adopting the method and the base material is excellent, and the super-hydrophilic performance of the surface of the coating makes the material have an excellent biological stain-resistant function, so that the biological stain-resistant coating with the long-acting super-hydrophilic performance can be used for preparing materials of implanted devices, medical diagnosis instruments, medical sensors and the like.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a biological antifouling coating with long-lasting superhydrophilic performance and a preparation method thereof, which can be used for the preparation of materials such as implanted devices, medical diagnostic devices, and medical sensors. Background technique [0002] The non-specific adsorption of proteins and the attachment and growth of microorganisms are a major challenge in the field of biomedical devices. Proteins are easy to non-specifically adsorb on the surface of materials, especially on the surface of biomedical materials. For implantable devices, after the material is implanted into the host, it exists in the state of exogenous substances when it comes into contact with the biological environment, causing adverse reactions (foreign body reactions) to the organism to varying degrees. These reactions are all related to the rapid adsorption of non...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/14C09D5/16
CPCA61L31/08A61L31/14A61L2400/18A61L2420/06C09D5/16
Inventor 罗日方王云兵李林华李高参杨立
Owner SICHUAN UNIV
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