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Coronary artery microembolism animal model

A technology for embolizing animals and coronary arteries, which is used in medical science, veterinary instruments, and veterinary surgery. Equipment requirements are high, and the success rate and repeatability of the model are increased, the mortality rate of rats is reduced, and the effect is easy to master.

Inactive Publication Date: 2018-12-18
李浪
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the coronary microembolism model constructed by the prior art has the following defects: the pathophysiological process of the natural evolution of tubular arterial microembolism cannot be successfully simulated; anesthesia drugs have a greater impact on breathing and circulation, resulting in high mortality in the animal surgery process; in addition , the coronary microembolism model in the prior art has relatively high requirements on cost, technology and equipment, resulting in high model establishment costs

Method used

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  • Coronary artery microembolism animal model
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Embodiment Construction

[0018] The specific embodiments provided by the present invention will be described in detail below in conjunction with the accompanying drawings.

[0019] 1. Experimental animals, main equipment, materials and reagents:

[0020] 200-300g SD rats, 45μm polyethylene microembolization ball (5×105u / ml), ALC-V9A small animal ventilator, ALC-HTP203 animal constant temperature system, MPA cardiac function analyzer, SPLab01 single-channel syringe pump, vortex mixer , small animal operating table, rat immobilizer, pressure steam sterilizer, endotracheal tube, 1ml, 10ml syringe, rat chest opener, needle holder, ophthalmic scissors, glassware, retractor, toothed forceps, toothless forceps , blades, vascular clamps, curved hemostats, suture needles, propofol injection (20ml, 200mg / piece), 0.9% sodium chloride injection, penicillin sodium for injection.

[0021] 2. Item preparation:

[0022] Divide the microspheres: divide the microspheres into EP tubes according to the needs, add an ap...

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Abstract

The invention provides a coronary artery microembolism animal model. According to the invention, the model is used for injecting the SDS normal saline suspension of the polystyrene microsphere into the apex of the left ventricle of an experimental animal while the aorta of the animal is clamped and closed at the same time. After that, the blood supply is restored again after a plurality of cardiaccycles of the aorta rising aorta are further kept. The coronary artery microembolism animal model has the advantages of being low in cost, low in animal death rate and high in simulation degree. By means of the model, an important research foundation is provided for preventing and treating coronary artery microembolism, the research and development of medicines and instruments for the coronary artery microembolism.

Description

technical field [0001] The invention relates to the field of disease animal models in biomedicine, in particular to a coronary artery microembolism animal model. Background technique [0002] Coronary microembolization (CME) is a common complication in patients with coronary heart disease, especially acute coronary syndrome (ACS). The main mechanism of tubular arterial microembolism is the spontaneous rupture of plaque, extrusion and fragmentation during coronary intervention, microemboli produced by incomplete thrombolysis during thrombolysis, and the release of various vasoactive substances during this process. It not only leads to "slow blood flow" or "no reflow", but also is the main cause of affecting the microcirculation perfusion of coronary artery micromyocardium, and is an independent predictor of poor long-term prognosis and mortality in patients with acute myocardial infarction. [0003] With the in-depth development of clinical and animal research on coronary ar...

Claims

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Application Information

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IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 李浪苏强孙羽涵陆元喜龙曼云郑静
Owner 李浪
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