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Rhodiola rosea chewable tablet and preparation method thereof

A technique for Rhodiola rosea and chewable tablets, which is applied in the field of traditional Chinese medicine, can solve the problems of easy deliquescence and unfavorable preservation of chewable tablets, and achieves the effects of simple and feasible preparation method, enhancement of body immunity, and low production cost.

Inactive Publication Date: 2019-01-08
TONGHUA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Rhodiola rosea for chewable tablets contains a large amount of tannins, which makes the chewable tablets easy to deliquescence and is not conducive to preservation

Method used

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  • Rhodiola rosea chewable tablet and preparation method thereof
  • Rhodiola rosea chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A Rhodiola rosea chewable tablet is composed of the following ingredients and raw materials in parts by weight: 10 parts of Rhodiola rosea extract, 23 parts of microcrystalline cellulose, 10 parts of mannitol, 5 parts of single crystal rock sugar powder, and 0.01 part of mint.

[0020] A preparation method of rhodiola rosea chewable tablet, comprising preparation of rhodiola rosea extract, premixing of medicated powder, granulation, granulation, specifically comprising the following steps:

[0021] 1) Preparation of Rhodiola rosea extract: Add 75% ethanol solution to Rhodiola rosea powder according to the material-to-liquid ratio of 1:35, then perform ultra-high pressure extraction at 300 MPa for 1 min, and open the pressure relief valve after extraction , release the pressure, then centrifuge for 10min at a speed of 12000r / min, then filter the supernatant through a 25μm microporous membrane, and concentrate the filtrate to a specific gravity of 1.2 after filtration to o...

Embodiment 2

[0027] A Rhodiola rosea chewable tablet is composed of the following components and raw materials in parts by weight: 20 parts of Rhodiola rosea extract, 10 parts of microcrystalline cellulose, 12 parts of mannitol, 1 part of single crystal rock sugar powder, and 0.2 parts of mint.

[0028] A preparation method of rhodiola rosea chewable tablet, comprising preparation of rhodiola rosea extract, premixing of medicated powder, granulation, granulation, specifically comprising the following steps:

[0029] 1) Preparation of rhodiola extract: add 80% ethanol solution to the rhodiola powder according to the ratio of material to liquid at 1:25, then extract at 200 MPa under ultra-high pressure for 3 minutes, and open the pressure relief valve after the extraction , release the pressure, then centrifuge 20min under the condition of 8000r / min at a rotating speed, then filter the supernatant through a 0.2 μm microporous membrane, and after filtering, concentrate the filtrate to a specif...

Embodiment 3

[0034] A Rhodiola rosea chewable tablet is composed of the following ingredients and raw materials in parts by weight: 20 parts of Rhodiola rosea extract, 23 parts of microcrystalline cellulose, 12 parts of mannitol, 5 parts of single crystal rock sugar powder, and 0.1 part of mint.

[0035] A preparation method of rhodiola rosea chewable tablet, comprising preparation of rhodiola rosea extract, premixing of medicated powder, granulation, granulation, specifically comprising the following steps:

[0036] 1) Preparation of rhodiola extract: add 78% ethanol solution to the rhodiola powder according to the ratio of material to liquid at 1:30, then extract at 250 MPa under ultra-high pressure for 2 minutes, and open the pressure relief valve after the extraction , release the pressure, then centrifuge for 15min under the condition of 10000r / min at a rotating speed, then filter the supernatant through a 0.22 μm microporous membrane, and after filtering, concentrate the filtrate to a...

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Abstract

The invention discloses a rhodiola rosea chewable tablet and a preparation method thereof. The chewable tablet comprises the following ingredients in parts by weight: 10-20 parts of rhodiola rosea extract, 10-23 parts of microcrystalline cellulose, 10-12 parts of mannitol, 1-5 parts of monocrystal rock sugar powder and 0.01-0.2 part of menthae haplocalycis herba. The preparation method of the chewable tablet comprises the following steps: adding an ethyl alcohol solution into rhodiola rosea powder, and extracting the rhodiola rosea extract at ultrahigh pressure; adding microcrystalline cellulose and mannitol into the rhodiola rosea extract, stirring evenly, drying, and grinding to obtain drug powder; adding the monocrystal rock sugar powder into the drug powder, pelletizing, drying, sieving, and spraying an ethyl alcohol solution of menthae haplocalycis herba to obtain granules; adding magnesium stearate into the granules, and tableting to obtain the rhodiola rosea chewable tablet. Therhodiola rosea chewable tablet has the benefits that the production cost of the rhodiola rosea chewable tablet is low, various indexes meet the relevant technical requirements, the rhodiola rosea chewable tablet is dissolved rapidly, has an obvious drug effect, and does not absorb moisture easily; the preparation method is simple and feasible, and the content of tannin in the prepared rhodiola rosea extract is low.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a Rhodiola rosea chewable tablet and a preparation method thereof. Background technique [0002] Rhodiola rosea (Rhodiola rosea L.) is a traditional Chinese medicine in my country, which belongs to the genus Rhodiola (Rhodiola L) of Crassulaceae (Crassulaceae), and it is a perennial herb or subshrub wild plant. Because the plant contains anthocyanin, its flowers, roots, stems and leaves are red, and the infusion is also red, so it is called Rhodiola rosea; it is a kind of plant resource with both medicine and food, and it is a plant that grows at an altitude of more than 3000 meters. Rare plateau plants in alpine regions can grow in harsh and changeable natural environments, such as high altitude, cold, dry, oxygen-scarce, and strong ultraviolet light. At present, scholars at home and abroad have isolated more than 40 kinds of chemical substances from differ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K36/41A61P39/00A61P31/12A61P37/04A61P17/16
CPCA61K9/0056A61K9/2054A61K36/41A61K2236/333A61K2236/37A61K2236/51A61K2236/53A61P17/16A61P31/12A61P37/04A61P39/00
Inventor 薛长松夏广清朱俊义
Owner TONGHUA NORMAL UNIV
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