A method for preparing ceramide from rice bran by fermentation method

Abstract

The invention belongs to the technical field of fermentation engineering, and in particular relates to a method for preparing ceramide from rice bran by a fermentation method. The method comprises the following steps: after removing impurities, pulverizing and sieving the rice bran, adding Ganoderma lucidum to the rice bran powder for fermentation; separating the fermented liquid, taking the clear liquid to obtain a ceramide solution, and concentrating and crystallizing the obtained ceramide solution to obtain Ceramide solid. The present invention utilizes Ganoderma lucidum to ferment rice bran, which not only can significantly improve the dissolution of ceramide in rice bran, but also produces a certain amount of ceramide from Ganoderma lucidum. Environmental protection, and not subject to regional climate restrictions, can significantly reduce economic costs.

Description

technical field [0001] The invention belongs to the technical field of fermentation engineering, and in particular relates to a method for preparing ceramide from rice bran by a fermentation method. Background technique [0002] Ceramide is N-fatty acyl sphingosine, also known as molecular nails and sialome, is a signal transduction substance widely present in eukaryotic cells, mainly as a structural component of cell membrane or intracellular Exists in free molecular form. Ceramide is an active ingredient in pharmaceuticals, food and cosmetics that has received much attention in recent years. According to reports, the biological functions of ceramide mainly include the following aspects: ① cell adhesion; ② regulation of cell proliferation and differentiation; ③ induction of apoptosis ; ③ regulation of protein secretion; ④ the role of inflammation. The application in cosmetics can act as a barrier to prevent the loss of water, and has the functions of protecting and repair...

AI Technical Summary

Problems solved by technology

The content of ceramide in rice bran is relatively high, as in the patents "composition containing ceramide extracted from rice bran as an active ingredient and having anti-atopic activity [(publication (announcement) number: CN105311041A]" and "a kind of The method for extracting high-purity ceramide from rice bran [(public (announcement) number: CN106008253B] ", all provide the use of organic solvents such as ethanol, petroleum ether, through long-term heating and leaching to prepare ceramide from rice bran However, due to the cell wall structure of plant cells, the substances in the wall are not easy to be separated and extracted, resulting in large energy consumption, large amount of organic solvent and low extraction yield during the extraction process.

However, in "A Process for Preparation of Ceramide by Fermentation [(Publication (Announcement) No.: CN106119310A]", Penicillium purpurea was used to prepare ceramide by fermentation. Although this invention simplifies the preparation process of ceramide, but Using methanol as a solvent in the preparation process, the residual methanol will cause harm to the human body, and the production cycle of the invention is longer