High-efficiency antibacterial nano iron sulfide mixture as well as preparation method and application thereof

A technology of iron sulfide and mixtures, applied in botany equipment and methods, nano-medicines, applications, etc., can solve the problems of difficulty in the effective treatment of Candida albicans, and achieve the effects of easy magnetic separation, good dispersion, and promotion of ROS generation

Inactive Publication Date: 2019-02-22
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Effective treatment of Candida albicans becomes increasingly difficult as its pathogenicity rate increases and drug resistance increases

Method used

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  • High-efficiency antibacterial nano iron sulfide mixture as well as preparation method and application thereof
  • High-efficiency antibacterial nano iron sulfide mixture as well as preparation method and application thereof
  • High-efficiency antibacterial nano iron sulfide mixture as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1: the preparation method of the nano iron sulfide mixture of L-cysteine ​​(cysteine) source

[0071] Dissolve 0.82 g of anhydrous ferric chloride in 40 ml of ethylene glycol, and stir with a magnetic stirrer for 30 minutes to fully dissolve the anhydrous ferric chloride to obtain a ferric chloride solution. Add 0.36 g of sodium acetate trihydrate to the ferric chloride solution, and stir with a magnetic stirrer for 30 minutes to fully dissolve the sodium acetate to prepare a mixed solution. Add 0.5 g of L-cysteine ​​to the above mixed solution and stir for 30 minutes to fully dissolve the L-cysteine ​​to prepare a reaction solution. Then pour all the reaction solution into the reaction kettle, put the reaction kettle into an oven, then raise the temperature of the oven to 200° C., keep warm, heat for 12 hours, wash with alcohol three times, and dry to obtain a nano-iron sulfide mixture. The scanning electron microscope image of the nano-iron sulfide mixture...

Embodiment 2

[0072] Embodiment 2: the preparation method of the nano iron sulfide mixture of cystine (cystine) source

[0073] Dissolve 0.82 g of anhydrous ferric chloride in 40 ml of ethylene glycol, and stir with a magnetic stirrer for 30 minutes to fully dissolve the anhydrous ferric chloride to obtain a ferric chloride solution. Add 0.36 g of sodium acetate trihydrate to the ferric chloride solution, and stir with a magnetic stirrer for 30 minutes to fully dissolve the sodium acetate to prepare a mixed solution. Add 0.5 g of cystine to the above mixed solution and stir for 30 minutes to fully dissolve the cystine to prepare a reaction solution. Then pour all the reaction solution into the reaction kettle, put the reaction kettle into an oven, then raise the temperature of the oven to 200° C., keep warm, heat for 12 hours, wash with alcohol three times, and dry to obtain a nano-iron sulfide mixture. The scanning electron microscope image of the nano-iron sulfide mixture derived from cy...

Embodiment 3

[0074] Embodiment 3: the preparation method of the nano iron sulfide mixture of GSH (glutathione) source

[0075] Dissolve 0.82 g of anhydrous ferric chloride in 40 ml of ethylene glycol, and stir with a magnetic stirrer for 30 minutes to fully dissolve the anhydrous ferric chloride to obtain a ferric chloride solution. Add 0.36 g of sodium acetate trihydrate to the ferric chloride solution, and stir with a magnetic stirrer for 30 minutes to fully dissolve the sodium acetate trihydrate to prepare a mixed solution. Add 0.5 g of GSH to the above mixed solution and stir for 30 min to fully dissolve the GSH to obtain a reaction solution. Then pour all the reaction solution into the reaction kettle, put the reaction kettle into an oven, then raise the temperature of the oven to 200° C., keep warm, heat for 12 hours, wash with alcohol three times, and dry to obtain a nano-iron sulfide mixture. The scanning electron microscope image of the nano-iron sulfide mixture derived from GSH ...

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Abstract

The invention provides a broad-spectrum high-efficiency antibacterial nano iron sulfide mixture capable of inhibiting and killing multiple bacteria and fungi as well as a preparation method and application of the nano iron sulfide mixture. The preparation method of the antibacterial nano iron sulfide mixture comprises the following steps: adding a sulfur source in the process of preparing nano ferroferric oxide particles by a solvothermal method, wherein the step of preparing the nano ferroferric oxide particles by a hydrothermal method or the solvothermal method comprises a sub-step of utilizing an iron source, an aqueous or non-aqueous solvent and an alkaline solution as a reactant. The nano iron sulfide mixture disclosed by the invention is excellent in dispersion property, easy to prepare, easy in magnetic separation, stable in performance, excellent in biocompatibility and long in antibacterial effect period, is harmless to the human body during conventional use, environment-friendly, eco-friendly, easy to control and low in price, and thus is a high-efficiency low-degree broad-spectrum antibacterial material.

Description

technical field [0001] The invention relates to the technical field of biological nanomaterials, in particular to a highly efficient antibacterial nano-iron sulfide mixture, in particular to a broad-spectrum and high-efficiency antibacterial nano-iron sulfide mixture capable of inhibiting and killing various bacteria and fungi and its preparation method and application , also relates to an antibacterial drug comprising a high-efficiency antibacterial nano-iron sulfide mixture. Background technique [0002] The development and application of high-efficiency antibacterial materials are of great significance for protecting human health, improving human living environment, reducing diseases, and responding to sudden biological pollution incidents. [0003] Nano antibacterial materials are a new class of materials developed on the basis of inorganic antibacterial materials and nanomaterials. At present, the nano-silver antibacterial agent is more developed and applied, which has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61P31/04A61P31/10B82Y5/00A01N59/16A01P3/00A01P1/00
CPCA01N59/16A61K33/26A61P31/04A61P31/10B82Y5/00Y02A50/30
Inventor 高利增许卓斌仇智月李丹丹
Owner YANGZHOU UNIV
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