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Preparation method and application of graphene freckle-removing patch

A graphene and freckle-removing technology, applied in the field of freckle-removing stickers, can solve the problems of accelerated skin aging, skin damage, etc., and achieve the effects of long-lasting medicinal time, low irritation and simple production method

Inactive Publication Date: 2019-03-19
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially for skin inflammation, pigmentation, chloasma and other skin care cosmetics, there are quite a lot of skin care cosmetics, and most of these skin care cosmetics are composed of emulsion or cream synthesized by chemical additives. It also damages the healthy skin and accelerates the aging of the skin

Method used

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  • Preparation method and application of graphene freckle-removing patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 graphene anti-freckle patch

[0028] Follow the steps below:

[0029] (1) Extraction of medicinal materials: get 20 parts of Speranthema japonicus, 20 parts of honeysuckle, 20 parts of white chrysanthemum, 15 parts of paeonol, 15 parts of salvia miltiorrhiza, 10 parts of pearl powder, 7 parts of cornus, 5 parts of kudzu rice by weight parts, pulverized, soaked in 80% ethanol solution for 3 hours, soaked 3 times, combined the leachate, concentrated under reduced pressure, clarified, decolorized, applied to AB-8 macroporous adsorption resin, eluted with 60% ethanol, and concentrated the eluate under reduced pressure. Dried to obtain the Chinese medicine extract with a yield of 73%;

[0030] (2) Preparation of graphene-based drug-loaded gel: disperse 200 mg of graphene powder in 1 L of Chinese medicine extract aqueous solution, ultrasonically obtain graphene dispersion for 1 h, stir vigorously, add 1 mol / L gelatin solution dropwise, and con...

Embodiment 2

[0032] The preparation of embodiment 2 graphene freckle-removing patch

[0033] Follow these steps:

[0034] (1) Extraction of medicinal materials: take 17 parts of bone grass, 18 parts of honeysuckle, 16 parts of white chrysanthemum, 13 parts of paeonol, 11 parts of salvia miltiorrhiza, 7 parts of pearl powder, 5 parts of cornus, 2 parts of kudzu rice by weight , pulverized, soaked in 70% ethanol solution for 3 hours, soaked 3 times, combined the leachate, concentrated under reduced pressure, clarified, decolorized, put on D4020 macroporous adsorption resin, eluted with 50% ethanol, concentrated the eluent under reduced pressure, and dried to obtain Chinese medicine extract, the yield rate is 94%;

[0035] (2) Preparation of graphene-based drug-loaded gel: disperse 200 mg of graphene powder in 1 L of Chinese medicine extract aqueous solution, ultrasonically obtain graphene dispersion for 1 h, stir vigorously, add 1 mol / L gelatin solution dropwise, and continue to stir fully ...

Embodiment 3

[0037] The preparation of embodiment 3 graphene freckle-removing patch

[0038] (1) Extraction of medicinal materials: get 15 parts of Speranthema japonicus, 15 parts of honeysuckle, 15 parts of white chrysanthemum, 10 parts of paeonol, 10 parts of salvia miltiorrhiza, 5 parts of pearl powder, 2 parts of cornus, 1 part of kudzu rice by weight. parts, crushed, soaked in 50% ethanol solution for 3 hours, soaked once, combined the leachate, concentrated under reduced pressure, clarified, decolorized, applied to S-8 macroporous adsorption resin, eluted with 30% ethanol, and concentrated the eluent under reduced pressure. Dried to obtain the Chinese medicine extract, the yield is 50%;

[0039](2) Preparation of graphene-based drug-loaded gel: disperse 200 mg of graphene powder in 1 L of Chinese medicine extract aqueous solution, ultrasonically obtain graphene dispersion for 1 h, stir vigorously, add 1 mol / L gelatin solution dropwise, and continue to stir fully 1h, after completely...

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Abstract

The invention discloses a graphene freckle-removing patch and a preparation method and an application thereof. The preparation method comprises the following steps of crushing garden balsam stem, honeysuckle, feverfew, the root bark of the peony tree, the root of red-rooted salvia, pearl powder, pulp of dogwood fruit and common nostoc; dipping the crushed mixture into an ethanol solution, mixing the leachate, concentrating under vacuum, clarifying and decolorizing, using AB-8 macroporous adsorptive resin to adsorb, eluting with ethanol, concentrating the elution under vacuum, drying to obtainChinese herb extracts; dispersing graphene powder into the Chinese herb extract solution, performing ultrasonic processing, mixing, dropwise adding a gelatin solution, mixing and standing to obtain graphene-gelatin drug-loaded hydrogel; uniformly mixing the product obtained in the last step, putting into a mould, solidifying and finalizing the design, thereby obtaining a graphene freckle-removingpatch. According to the graphene freckle-removing patch provided by the invention, the Chinese herb extract is combined with a graphene material to prepare hydrogel dosage forms, as the hydrogel dosage forms are applied into patches, the medical effect of the composition is maximized, patients are easy to absorb, and good freckle removing effect can be reached through improving oxidation resistance of skins.

Description

technical field [0001] The invention relates to the technical field of freckle-removing patches, in particular to a graphene freckle-removing patch. Background technique [0002] The types of spots on human skin mainly include the following types: (1) Melasma, also known as liver spots, is mostly distributed on the forehead, cheeks, nose, etc., presenting irregular patches, but symmetrically distributed. Most of the causes of chloasma are related to endocrine, while sun exposure and mental stress will aggravate the color of chloasma, showing large areas of light yellow spots; (2) black spots, also known as butterfly spots, are mostly concentrated on the cheeks, It looks like a butterfly. There are multiple factors that can cause dark spots. Long-term excessive ultraviolet radiation, aging and inflammation of the skin, or long-term acne and eczema will stimulate the reproduction of melanocytes at the bottom of the skin, produce excessive melanin, and eventually form dark sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61K9/70A61K47/04A61P17/00A61P39/06A61P31/04A61P31/10A61P31/02A61K35/618A61K35/748
CPCA61K9/7023A61K35/618A61K35/748A61K36/185A61K36/287A61K36/355A61K36/40A61K36/47A61K36/537A61K36/65A61K36/71A61K47/02A61K2236/333A61K2236/39A61K2236/55A61P17/00A61P31/02A61P31/04A61P31/10A61P39/06A61K2300/00
Inventor 赵立春唐农冷静宋策李俊秀江婵玲李玉凤
Owner GUANGXI UNIV OF CHINESE MEDICINE
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