Diazole-pyrazolecarboxamide derivative and microwave hydrothermal synthesis method and application thereof

A kind of technology of derivatives and amides, applied in the application of such compounds, N--amide derivatives and the field of microwave hydrothermal synthesis
CN109575006AInactive Publication Date: 2019-04-05SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
Publication Date
2019-04-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of organic synthesis, in particular to a N-(5-[1,3,4]diazole-2-yl-2H-pyrazole-3-yl)-carboxamide derivative and a microwave hydrothermal synthesis method thereof, and further relates to application of the compound. A series of basic raw materials such as amine, 2,3-dicyan-opropionate, alcohol, acyl halide and the like are used for synthetizing of pyrazolecarbonitrile, pyrazolecarbonitrile is subjected to esterification, hydrazide reaction and amidation and reacts with a cyclization agent by the microwave hydrothermal synthesis method so as to obtainN-(5-[1,3,4]diazole-2-yl-2H-pyrazole-3-yl)-carboxamide derivative (including thiadiazole and oxadiazole). The derivative has good biological activity, can inhibit various bacterial stains, and has high activity in terms of bacterial resistance and insect killing; in terms of chemical structure, the derivative, according with the general formula, is synthetized, has great variety of active groups and excellent photo-physical properties, has multiple functions in the fields such as photoelectricity, medicines, pesticides, bacteriostat, diminish inflammation and virus protection, and accordinglyhas high development and application value.
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Description

technical field

[0001] The invention relates to the technical field of organic synthesis, in particular to an N-(5-[1,3,4]oxadiazol-2-yl-2H-pyrazol-3-yl)-amide derivative and its microwave hydrothermal The synthesis method also relates to the application of this type of compound. Background technique

[0002] Thiadiazole compounds can play a variety of non-covalent bond interaction and coordination properties because they are easy to form hydrogen bonds and coordination bonds, and have anti-oxidation, anti-virus and anti-ulcer properties, especially for golden yellow Staphylococcus and Escherichia coli have obvious inhibitory effect. Pyrazole compounds can be used for sterilization, insecticide, weed control, anti-virus, promotion of plant growth and anti-cancer, etc., and have potential application value in the fields of pharmacy, medicine, and coordination chemistry. Pyrazole amide compounds have antibacterial, antiviral, anti-inflammatory and other uses in terms of biol...

Claims

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