Polycaprolactone/nano-hydroxyapatite composite material and method for preparing same

Abstract

The invention relates to a polycaprolactone / nano-hydroxyapatite composite material and a method for preparing the same. The method includes steps of (1), weighing dried nano-hydroxyapatite and monomers epsilon-caprolactone according to certain mass ratios, and uniformly dispersing and mixing the nano-hydroxyapatite and the monomers epsilon-caprolactone with one another in ultrasound to form mixedsuspension; (2), carrying out ring-opening polymerization reaction on the mixed suspension and initiators according to certain ratios; (3), repeatedly washing and precipitating products by deionized water, carrying out vacuum filter on the products and drying the products to obtain the polycaprolactone / nano-hydroxyapatite composite material. The polycaprolactone / nano-hydroxyapatite composite material and the method have the advantages that in-situ bulk polymerization is adopted, the nano-hydroxyapatite is uniformly dispersed in polycaprolactone materials, accordingly, the products are high inpurity, and toxic solvents are omitted in polymerization and after-treatment procedures; hydroxy acid is used as an initiator and a catalyst, accordingly, the method includes simple processes, and thepolycaprolactone / nano-hydroxyapatite composite material prepared by the aid of the method can be applied to bone repair materials.

Description

technical field [0001] The invention relates to a polycaprolactone / nanometer hydroxyapatite composite material and a preparation method thereof, belonging to the field of medical nanometer composite materials. Background technique [0002] Polycaprolactone (PCL) has excellent biodegradability, good biocompatibility and mechanical properties, and is a class of biomedical materials approved by the US Food and Drug Administration (FDA). Polycaprolactone is a crystalline polymer with a melting point of 59-64°C and a glass transition temperature of around -60°C. It has good flexibility and processability; it also has excellent drug permeability and can be used As drug controlled release carrier. [0003] Hydroxyapatite (HA) is the main inorganic component in human and animal bones. Hydroxyapatite has excellent biocompatibility and bioactivity, nano-scale hydroxyapatite can be used as a bone or tooth inducing factor, and can be applied to bone tissue regeneration engineering. I...

AI Technical Summary

Problems solved by technology

The blending method usually adopts solution blending and melt blending. Although this method is simple, it is difficult to disperse nano-hydroxyapatite uniformly. The inorganic phase and organic phase in the composite material are only purely physically mixed, and the phase separation is obvious. This relatively weak combination will make the material easy to break under the action of external tensile stress, reducing the performance of the material

The copolymerization method is mainly realized by using hydroxyapatite as an initiator to initiate the ring-opening polymerization of caprolactone. The steric hindrance is increased by grafting polycaprolactone segments on the nanoparticles. Although it can be dispersed uniformly, due to the hydroxyapatite Stone nanoparticles are initiators, and its addition amount will affect the molecular weight of the polymer. Too much addition will lead to a decrease in the molecular weight of the polymer, resulting in a decrease in toughness and greater brittleness of the material.

At the same time, this method needs to add toxic solvents and metals or their compounds as catalysts, and the preparation process is complicated, which limits its application in the field of biomedical materials