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Cyclodextrin-metal organic framework material composite microspheres and preparation method thereof

A metal-organic framework and composite microsphere technology, which is applied in the direction of microsphere preparation, microcapsule preparation, organic active ingredients, etc., can solve the problems of cumbersome steps, long time-consuming, harsh reaction conditions, etc.

Active Publication Date: 2021-05-11
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These methods are time-consuming, complicated steps and harsh reaction conditions

Method used

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  • Cyclodextrin-metal organic framework material composite microspheres and preparation method thereof
  • Cyclodextrin-metal organic framework material composite microspheres and preparation method thereof
  • Cyclodextrin-metal organic framework material composite microspheres and preparation method thereof

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preparation example Construction

[0040] In a preferred embodiment of the present invention, it also relates to the preparation method of the above-mentioned cyclodextrin-metal organic framework material composite microspheres, comprising the following steps:

[0041] (A) providing a cyclodextrin-metal organic framework material, loading drugs on the cyclodextrin-metal organic framework material to obtain a drug-loaded cyclodextrin-metal organic framework material;

[0042] (B) ethyl cellulose is dissolved in an organic solvent to obtain an ethyl cellulose solution;

[0043] (C) mixing and dispersing the drug-loaded cyclodextrin-metal organic framework material and ethyl cellulose solution evenly to obtain a mixed solution;

[0044] (D) uniformly supply the mixed solution to the nozzle of the drug ultrafine particle preparation system through a peristaltic pump, adjust the rotation speed of the high-speed disc and the liquid supply speed, and the liquid flow is sheared and dispersed instantaneously to prepare ...

Embodiment 1

[0052] Preparation of CD-MOFs

[0053] Dissolve γ-cyclodextrin and potassium hydroxide in 200mL deionized water, and filter through a 0.8μm filter membrane after the two are completely dissolved, then add 120mL methanol to the filtrate, transfer to a 50°C water bath and heat for 0.5h. Then add 300mL methanol and CTAB (8mg·mL -1 ), CTAB was completely dissolved and left to stand at room temperature for 2 h. Finally, the CD-MOFs were collected by centrifugation, washed with isopropanol, and the solid was vacuum-dried overnight. Please participate in the PXRD pattern of prepared CD-MOFs figure 1 .

Embodiment 2

[0055] Preparation of CD-MOFs loaded with ketoprofen

[0056] 4g ketoprofen (KET) was dissolved in 100mL of acetone, the concentration was 40mg·mL -1 , then added 4 g of CD-MOFs, stirred for 24 h, and then washed twice with a KET-dissolving solvent to remove excess drug. The solid was vacuum-dried overnight to obtain ketoprofen-loaded CD-MOFs (KET-CD-MOFs). The PXRD pattern of the prepared drug-loaded CD-MOFs please participate in figure 2 .

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Abstract

The invention provides a novel cyclodextrin-metal organic framework material (CD-MOFs) composite microsphere and a preparation method thereof. The composite microspheres are prepared by using ethyl cellulose as a protective agent and wrapping a drug-loaded metal-organic framework compound with the ethyl cellulose. The preparation method is to mix and disperse the drug-loaded cyclodextrin-metal organic framework material with a certain proportion of ethyl cellulose solution evenly, and prepare microspheres in one step through the high-speed rotation of the ultrafine particle preparation system and the effect of solvent evaporation. The composite microspheres of the present invention improve the water stability and biocompatibility of the cyclodextrin-metal-organic framework material, realize the sustained release of drugs in vitro, and the preparation method does not require additional purification and drying steps, and the operation is simple and the conditions are mild. The process is stable and can be operated continuously.

Description

technical field [0001] The invention belongs to the field of biological materials, and more specifically relates to a cyclodextrin-metal organic framework material composite microsphere and a preparation method thereof. Background technique [0002] Metal-organic frameworks (MOFs) are emerging porous materials, which are formed by self-assembly of metal ions or metal oxygen clusters and organic ligands through coordination bonds. Due to their superior properties, such as large specific surface area and pore volume, and tunable pore structure, various MOFs have been designed and applied in various fields, such as catalysis, gaseous alcohols, separation, sensing, and pharmaceuticals. deliver. However, the sensitivity of many MOFs to humidity limits their further applications. MOFs with weaker coordination bonds or hydrophilic organic ligands are usually water-labile and prone to structural collapse in aqueous environments. [0003] Cyclodextrin-metal-organic frameworks (CD-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/192A61K47/69A61K47/38B01J13/02
CPCA61K9/5042A61K31/192A61K47/6951B01J13/02
Inventor 吴传斌罗苏兰吴碧湲牛博艺周奕先权桂兰
Owner SUN YAT SEN UNIV
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