Freeze-dried powder having whitening activity and preparation method and application of freeze-dried powder

A freeze-dried powder and active technology, which is applied in the field of freeze-dried powder with whitening activity and its preparation, can solve the problems of increasing stimuli, easy discoloration, irritation, etc., to reduce production costs, shorten freeze-drying time, and eliminate The effect of stimulating the skin

Active Publication Date: 2019-09-13
珠海美逸生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

1. Antioxidant whitening active substances mainly include vitamin C, vitamin E and their derivatives. The disadvantage is that they are easily oxidized and inactivated and have a certain degree of irritation. They are easy to change color when added to the product, thus limiting their use; 2. 1. Substances that inhibit tyrosinase activity mainly include tranexamic acid, arbutin, kojic acid, and small molecule active peptides, which also have problems such as irritation and discoloration; 3. Substances that accelerate the metabolism of the stratum corneum to achieve whiteni

Method used

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  • Freeze-dried powder having whitening activity and preparation method and application of freeze-dried powder
  • Freeze-dried powder having whitening activity and preparation method and application of freeze-dried powder
  • Freeze-dried powder having whitening activity and preparation method and application of freeze-dried powder

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 experimental group sample

[0043] 1. Preparation of whitening lyophilized powder

[0044] The formula of each component of the whitening freeze-dried powder is shown in Table 1. Weigh deionized water, tranexamic acid, nicotinamide, mannitol, and ascorbyl glucoside according to the weight ratio. Bottles are filled, and then placed in a vacuum dryer. The vacuum freeze-drying parameters are as follows: first place at -45°C, pre-freeze for 2h; gradient temperature method for one drying, -20°C, 3h; -5°C, 5h; then Carry out secondary drying, quickly raise the temperature to 30°C for 3h, then quickly enter the ultimate vacuum state, and keep at 30°C for 4h.

[0045] Table 1. Formula table of whitening freeze-dried powder

[0046]

[0047] 2. Preparation of whitening freeze-dried powder vehicle

[0048] The formula of the whitening freeze-dried powder solvent is shown in Table 2. After the solvent is prepared, it will be filled in 2.5 mL a...

Embodiment 2

[0052] The preparation of embodiment 2 control group sample

[0053] 1. Preparation of Whitening Essence

[0054] The whitening essence formula is shown in Table 3. According to the increasing dosage of tranexamic acid, niacinamide, and ascorbyl glucoside, three gradient samples were made, and deionized water, glycerin, and sodium hyaluronate were dispersed at 85°C according to the weight ratio. After cooling down to room temperature evenly, add tranexamic acid, nicotinamide, ascorbyl glucoside, propylene glycol, bis(hydroxymethyl)imidazolidinyl urea, and iodopropynyl butyl carbamate and stir to dissolve completely.

[0055] Table 3. Preparation of whitening essence

[0056]

[0057] 2. Preparation of Whitening and Moisturizing Cream

[0058] The formula of whitening and moisturizing cream is shown in Table 4. According to the increase of the dosage of tranexamic acid, niacinamide, and ascorbyl glucoside, three gradient samples were made, and deionized water, glycerin, hy...

Embodiment 3

[0062] The stability test comparison of embodiment 3 experimental group and control group

[0063] 1. The results of formula screening and evaluation of the experimental group are shown in Table 5. Selecting a suitable filler ratio makes the preparation easy to freeze-dry and maintain a good appearance and mechanical strength.

[0064] Table 5. Formula screening table of experimental group

[0065]

[0066] It can be seen from Table 5 that formula 4 has the best molding effect and the best mechanical strength after selecting the ratio of formula 4 based on various technical indicators. Therefore, formula 4 was selected as the experimental group of whitening freeze-dried powder.

[0067] 2. Stability test comparison such as Table 6 and figure 1 . The ratio of the active whitening ingredients in formula A of the whitening essence and moisturizing cream of the control group was designed according to the ratio of the active whitening ingredients acting on the test body after ...

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Abstract

The invention provides freeze-dried powder having whitening activity and a preparation method and application of the freeze-dried powder. The freeze-dried powder consists of tranexamic acid, nicotinamide, mannan and ascorbyl glucoside. The freeze-dried powder can effectively lighten melanin; after being used for a long term, the freeze-dried powder can brighten skin color and whiten skin; the freeze-dried powder is free from chemical preservatives, does not stimulate the skin, is stable, does not change color, and is high in product activity, safe and effective. The invention also provides a preparation method of the freeze-dried powder. The freeze-drying time can be effectively shortened, the freeze-dried powder is energy-saving and environmentally-friendly, the production cost is reduced, and a freeze-dried powder product which is good in shaping effects, firm in appearance, high in redissolution speed and good in solution clarity can be prepared. Besides, the freeze-dried powder canalso be directly added to other cosmetics in a liquid preparation formulation, such as essence and moisturizer to dissolve for use, and can also mutually dissolve with a solvent to be added to cosmetics in a solid preparation formulation, such as moisturizing cream, to be uniformly stirred for use, so as to reinforce effects, and a new development thinking is provided for development of whiteningproducts.

Description

technical field [0001] The invention belongs to the field of cosmetics, in particular to a freeze-dried powder with whitening activity and its preparation method and application. Background technique [0002] With the development of the economy and the improvement of people's living standards, people pay more and more attention to the whitening of the skin, especially Asian women pay more attention to the whitening of the skin, and require the research of more natural, safer and milder whitening agents, which also makes Whitening products are developing rapidly. [0003] According to the whitening mechanism, the current whitening active substances are mainly divided into three categories. 1. Antioxidant whitening active substances mainly include vitamin C, vitamin E and their derivatives. The disadvantage is that they are easily oxidized and inactivated and have a certain degree of irritation. They are easy to change color when added to the product, thus limiting their use;...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/44A61K8/34A61K8/02A61Q19/00A61Q19/02
CPCA61K8/676A61K8/675A61K8/44A61K8/345A61K8/022A61Q19/00A61Q19/02A61K2800/84
Inventor 蔡敬贤熊盛陈红英陈伟邓小英王丹丹
Owner 珠海美逸生物科技有限公司
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